TAB1

 

Full name: TGF-beta activated kinase 1 (MAP3K7) binding protein 1 Alias Symbol: 
Type: protein-coding gene Cytoband: 22q13.1
Entrez ID: 10454 HGNC ID: HGNC:18157 Ensembl Gene: ENSG00000100324 OMIM ID: 602615
Drug and gene relationship at DGIdb

 

TAB1 involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04064NF-kappa B signaling pathway
hsa04380Osteoclast differentiation
hsa04620Toll-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection

 

Expression of TAB1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 TAB1 10454 203901_at 0.0007 0.9988
GSE20347 TAB1 10454 203901_at 0.1787 0.0361
GSE23400 TAB1 10454 203901_at -0.0203 0.5567
GSE26886 TAB1 10454 203901_at 0.4443 0.0070
GSE29001 TAB1 10454 203901_at 0.2143 0.0901
GSE38129 TAB1 10454 203901_at 0.0406 0.6437
GSE45670 TAB1 10454 203901_at -0.0366 0.7089
GSE63941 TAB1 10454 203901_at 0.0816 0.6809
GSE77861 TAB1 10454 203901_at -0.1115 0.2784
GSE97050 TAB1 10454 A_23_P80342 -0.1316 0.6403
SRP007169 TAB1 10454 RNAseq 0.4995 0.4367
SRP008496 TAB1 10454 RNAseq 0.6571 0.1317
SRP064894 TAB1 10454 RNAseq 0.4625 0.0108
SRP133303 TAB1 10454 RNAseq -0.1341 0.3257
SRP159526 TAB1 10454 RNAseq -0.1126 0.5006
SRP193095 TAB1 10454 RNAseq 0.1154 0.2153
SRP219564 TAB1 10454 RNAseq 0.1125 0.7530
TCGA TAB1 10454 RNAseq -0.0184 0.7184

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by TAB1 expression:

 

TCGA

 

Note: Click image to view full size file.  

Copy number change of TAB1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 TAB1 10454 6 5 19
GSE20123 TAB1 10454 6 4 20
GSE43470 TAB1 10454 5 6 32
GSE46452 TAB1 10454 32 2 25
GSE47630 TAB1 10454 9 4 27
GSE54993 TAB1 10454 4 5 61
GSE54994 TAB1 10454 10 7 36
GSE60625 TAB1 10454 5 0 6
GSE74703 TAB1 10454 5 4 27
GSE74704 TAB1 10454 3 2 15
TCGA TAB1 10454 27 15 54

Total number of gains: 112; Total number of losses: 54; Total Number of normals: 322.  

 

Somatic mutations of TAB1:

 

Generating mutation plots.

 

Highly correlated genes for TAB1:

 

Showing top 20/320 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
TAB1ZNF4670.796332303
TAB1CCND30.79516303
TAB1PLCL10.771308303
TAB1TMEM1400.763492303
TAB1PSMC3IP0.762816303
TAB1GNG70.760629303
TAB1FOXP40.758715303
TAB1SH2B10.758647303
TAB1KIAA05130.758031303
TAB1ZBTB100.751665303
TAB1TMEM170B0.747773303
TAB1FRZB0.747658303
TAB1GBA20.743429303
TAB1KCND30.742688303
TAB1MMP150.742683303
TAB1MAP1S0.734301404
TAB1ROMO10.733546303
TAB1CAMTA10.725237403
TAB1HIGD2A0.716714403
TAB1ZNF4190.714777303

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