| Full name: amine oxidase copper containing 3 | Alias Symbol: VAP1|HPAO|VAP-1 | ||
| Type: protein-coding gene | Cytoband: 17q21.31 | ||
| Entrez ID: 8639 | HGNC ID: HGNC:550 | Ensembl Gene: ENSG00000131471 | OMIM ID: 603735 |
| Drug and gene relationship at DGIdb | |||
Expression of AOC3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AOC3 | 8639 | 204894_s_at | -2.1990 | 0.0559 | |
| GSE20347 | AOC3 | 8639 | 204894_s_at | -0.7383 | 0.0351 | |
| GSE23400 | AOC3 | 8639 | 204894_s_at | -1.0416 | 0.0000 | |
| GSE26886 | AOC3 | 8639 | 204894_s_at | 1.5925 | 0.0029 | |
| GSE29001 | AOC3 | 8639 | 204894_s_at | -1.0689 | 0.0455 | |
| GSE38129 | AOC3 | 8639 | 204894_s_at | -1.4528 | 0.0047 | |
| GSE45670 | AOC3 | 8639 | 204894_s_at | -3.5372 | 0.0000 | |
| GSE53622 | AOC3 | 8639 | 97999 | -2.1570 | 0.0000 | |
| GSE53624 | AOC3 | 8639 | 97999 | -2.0605 | 0.0000 | |
| GSE63941 | AOC3 | 8639 | 204894_s_at | -2.0463 | 0.0016 | |
| GSE77861 | AOC3 | 8639 | 204894_s_at | 0.2075 | 0.2567 | |
| GSE97050 | AOC3 | 8639 | A_23_P426305 | -1.3739 | 0.0959 | |
| SRP007169 | AOC3 | 8639 | RNAseq | 1.6868 | 0.0016 | |
| SRP064894 | AOC3 | 8639 | RNAseq | -0.5565 | 0.1545 | |
| SRP133303 | AOC3 | 8639 | RNAseq | -1.4042 | 0.0126 | |
| SRP159526 | AOC3 | 8639 | RNAseq | -1.2526 | 0.0447 | |
| SRP219564 | AOC3 | 8639 | RNAseq | -0.8842 | 0.3963 | |
| TCGA | AOC3 | 8639 | RNAseq | -0.7833 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 9.
Survival by AOC3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AOC3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AOC3 | 8639 | 6 | 2 | 22 | |
| GSE20123 | AOC3 | 8639 | 6 | 2 | 22 | |
| GSE43470 | AOC3 | 8639 | 1 | 2 | 40 | |
| GSE46452 | AOC3 | 8639 | 34 | 0 | 25 | |
| GSE47630 | AOC3 | 8639 | 8 | 1 | 31 | |
| GSE54993 | AOC3 | 8639 | 3 | 4 | 63 | |
| GSE54994 | AOC3 | 8639 | 8 | 5 | 40 | |
| GSE60625 | AOC3 | 8639 | 4 | 0 | 7 | |
| GSE74703 | AOC3 | 8639 | 1 | 1 | 34 | |
| GSE74704 | AOC3 | 8639 | 4 | 1 | 15 | |
| TCGA | AOC3 | 8639 | 22 | 7 | 67 |
Total number of gains: 97; Total number of losses: 25; Total Number of normals: 366.
Somatic mutations of AOC3:
Generating mutation plots.
Highly correlated genes for AOC3:
Showing top 20/1281 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AOC3 | CLEC3B | 0.85825 | 3 | 0 | 3 |
| AOC3 | UBXN10 | 0.856343 | 3 | 0 | 3 |
| AOC3 | CYP21A2 | 0.853193 | 3 | 0 | 3 |
| AOC3 | XKR4 | 0.852437 | 5 | 0 | 5 |
| AOC3 | PLN | 0.846747 | 13 | 0 | 13 |
| AOC3 | PREX2 | 0.832674 | 4 | 0 | 4 |
| AOC3 | ANGPTL1 | 0.830972 | 7 | 0 | 6 |
| AOC3 | MEOX2 | 0.830423 | 8 | 0 | 8 |
| AOC3 | OGN | 0.827116 | 10 | 0 | 10 |
| AOC3 | ARHGAP6 | 0.826508 | 10 | 0 | 10 |
| AOC3 | MYL9 | 0.825109 | 11 | 0 | 10 |
| AOC3 | LMOD1 | 0.820951 | 13 | 0 | 13 |
| AOC3 | ACTG2 | 0.820448 | 13 | 0 | 12 |
| AOC3 | RBPMS2 | 0.817682 | 8 | 0 | 8 |
| AOC3 | MRVI1 | 0.816568 | 8 | 0 | 8 |
| AOC3 | MYOCD | 0.815589 | 7 | 0 | 7 |
| AOC3 | CNN1 | 0.814128 | 11 | 0 | 10 |
| AOC3 | CASQ2 | 0.812457 | 11 | 0 | 10 |
| AOC3 | DIXDC1 | 0.81208 | 10 | 0 | 9 |
| AOC3 | BHMT2 | 0.811695 | 9 | 0 | 9 |
For details and further investigation, click here
