| Full name: WD repeat domain 48 | Alias Symbol: KIAA1449|P80|SPG60 | ||
| Type: protein-coding gene | Cytoband: 3p22.2 | ||
| Entrez ID: 57599 | HGNC ID: HGNC:30914 | Ensembl Gene: ENSG00000114742 | OMIM ID: 612167 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
WDR48 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa03460 | Fanconi anemia pathway |
Expression of WDR48:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | WDR48 | 57599 | 221735_at | -0.4240 | 0.4068 | |
| GSE20347 | WDR48 | 57599 | 65591_at | -0.0792 | 0.3930 | |
| GSE23400 | WDR48 | 57599 | 65591_at | -0.1020 | 0.0295 | |
| GSE26886 | WDR48 | 57599 | 56919_at | -0.2732 | 0.1958 | |
| GSE29001 | WDR48 | 57599 | 56919_at | -0.3544 | 0.1891 | |
| GSE38129 | WDR48 | 57599 | 221735_at | -0.6958 | 0.0000 | |
| GSE45670 | WDR48 | 57599 | 65591_at | -0.0495 | 0.6947 | |
| GSE53622 | WDR48 | 57599 | 112465 | -0.4618 | 0.0000 | |
| GSE53624 | WDR48 | 57599 | 107360 | -0.3907 | 0.0000 | |
| GSE63941 | WDR48 | 57599 | 65591_at | 0.4888 | 0.0376 | |
| GSE77861 | WDR48 | 57599 | 65591_at | -0.1800 | 0.2000 | |
| GSE97050 | WDR48 | 57599 | A_33_P3297141 | -0.4086 | 0.2390 | |
| SRP007169 | WDR48 | 57599 | RNAseq | -0.8353 | 0.0066 | |
| SRP008496 | WDR48 | 57599 | RNAseq | -0.7583 | 0.0008 | |
| SRP064894 | WDR48 | 57599 | RNAseq | -0.3776 | 0.0037 | |
| SRP133303 | WDR48 | 57599 | RNAseq | -0.3407 | 0.0058 | |
| SRP159526 | WDR48 | 57599 | RNAseq | -0.5663 | 0.0001 | |
| SRP193095 | WDR48 | 57599 | RNAseq | -0.5791 | 0.0000 | |
| SRP219564 | WDR48 | 57599 | RNAseq | -0.6031 | 0.0415 | |
| TCGA | WDR48 | 57599 | RNAseq | -0.2399 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by WDR48 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of WDR48:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | WDR48 | 57599 | 0 | 19 | 11 | |
| GSE20123 | WDR48 | 57599 | 0 | 19 | 11 | |
| GSE43470 | WDR48 | 57599 | 0 | 20 | 23 | |
| GSE46452 | WDR48 | 57599 | 2 | 17 | 40 | |
| GSE47630 | WDR48 | 57599 | 1 | 25 | 14 | |
| GSE54993 | WDR48 | 57599 | 7 | 2 | 61 | |
| GSE54994 | WDR48 | 57599 | 0 | 34 | 19 | |
| GSE60625 | WDR48 | 57599 | 5 | 0 | 6 | |
| GSE74703 | WDR48 | 57599 | 0 | 16 | 20 | |
| GSE74704 | WDR48 | 57599 | 0 | 13 | 7 | |
| TCGA | WDR48 | 57599 | 1 | 71 | 24 |
Total number of gains: 16; Total number of losses: 236; Total Number of normals: 236.
Somatic mutations of WDR48:
Generating mutation plots.
Highly correlated genes for WDR48:
Showing top 20/428 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| WDR48 | BEND5 | 0.797921 | 3 | 0 | 3 |
| WDR48 | TCEAL1 | 0.784868 | 3 | 0 | 3 |
| WDR48 | VEZF1 | 0.784009 | 3 | 0 | 3 |
| WDR48 | GNG7 | 0.777977 | 3 | 0 | 3 |
| WDR48 | IGIP | 0.777955 | 3 | 0 | 3 |
| WDR48 | ING3 | 0.769924 | 3 | 0 | 3 |
| WDR48 | PRKAA2 | 0.766191 | 3 | 0 | 3 |
| WDR48 | C1QTNF7 | 0.7601 | 3 | 0 | 3 |
| WDR48 | ZBTB26 | 0.755974 | 3 | 0 | 3 |
| WDR48 | SMTNL2 | 0.755691 | 3 | 0 | 3 |
| WDR48 | ZNF383 | 0.748669 | 3 | 0 | 3 |
| WDR48 | TOX | 0.748215 | 3 | 0 | 3 |
| WDR48 | POGZ | 0.745801 | 3 | 0 | 3 |
| WDR48 | C3orf70 | 0.737582 | 3 | 0 | 3 |
| WDR48 | GNPDA2 | 0.736226 | 3 | 0 | 3 |
| WDR48 | ZRANB1 | 0.723596 | 3 | 0 | 3 |
| WDR48 | ZNF548 | 0.721492 | 4 | 0 | 4 |
| WDR48 | RNF146 | 0.719454 | 4 | 0 | 4 |
| WDR48 | NR1H2 | 0.718529 | 3 | 0 | 3 |
| WDR48 | TYW3 | 0.718429 | 3 | 0 | 3 |
For details and further investigation, click here
