ITPR1

 

Full name: inositol 1,4,5-trisphosphate receptor type 1 Alias Symbol: Insp3r1|IP3R1|ACV|PPP1R94
Type: protein-coding gene Cytoband: 3p26.1
Entrez ID: 3708 HGNC ID: HGNC:6180 Ensembl Gene: ENSG00000150995 OMIM ID: 147265
Drug and gene relationship at DGIdb

 

ITPR1 involved pathways:

KEGG pathway Description View
hsa04020Calcium signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04114Oocyte meiosis
hsa04270Vascular smooth muscle contraction
hsa04540Gap junction
hsa04611Platelet activation
hsa04713Circadian entrainment
hsa04720Long-term potentiation
hsa04723Retrograde endocannabinoid signaling
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04726Serotonergic synapse
hsa04728Dopaminergic synapse
hsa04730Long-term depression
hsa04750Inflammatory mediator regulation of TRP channels
hsa04912GnRH signaling pathway
hsa04915Estrogen signaling pathway
hsa04918Thyroid hormone synthesis
hsa04921Oxytocin signaling pathway
hsa04922Glucagon signaling pathway
hsa04924Renin secretion
hsa04925Aldosterone synthesis and secretion
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa05010Alzheimer's disease
hsa05016Huntington's disease
hsa05205Proteoglycans in cancer

 

Expression of ITPR1:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ITPR1 3708 203710_at -1.0647 0.1147
GSE20347 ITPR1 3708 203710_at -0.5591 0.0094
GSE23400 ITPR1 3708 203710_at -0.5843 0.0008
GSE26886 ITPR1 3708 203710_at -0.2172 0.4937
GSE29001 ITPR1 3708 203710_at -0.3877 0.3778
GSE38129 ITPR1 3708 203710_at -0.9832 0.0011
GSE45670 ITPR1 3708 203710_at -1.4183 0.0000
GSE53622 ITPR1 3708 28136 -1.2212 0.0000
GSE53624 ITPR1 3708 28136 -1.1478 0.0000
GSE63941 ITPR1 3708 203710_at -2.9555 0.0267
GSE77861 ITPR1 3708 216944_s_at -0.0082 0.9697
GSE97050 ITPR1 3708 A_23_P92042 -0.9940 0.1438
SRP007169 ITPR1 3708 RNAseq 0.2470 0.6411
SRP008496 ITPR1 3708 RNAseq 0.6313 0.0618
SRP064894 ITPR1 3708 RNAseq -0.5540 0.0658
SRP133303 ITPR1 3708 RNAseq -1.2936 0.0000
SRP159526 ITPR1 3708 RNAseq -0.9798 0.0035
SRP193095 ITPR1 3708 RNAseq -0.1465 0.4698
SRP219564 ITPR1 3708 RNAseq -0.6508 0.4626
TCGA ITPR1 3708 RNAseq -0.6764 0.0000

Upregulated datasets: 0; Downregulated datasets: 5.  

 

Survival by ITPR1 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of ITPR1:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ITPR1 3708 1 19 10
GSE20123 ITPR1 3708 1 19 10
GSE43470 ITPR1 3708 0 21 22
GSE46452 ITPR1 3708 2 18 39
GSE47630 ITPR1 3708 1 24 15
GSE54993 ITPR1 3708 6 1 63
GSE54994 ITPR1 3708 2 31 20
GSE60625 ITPR1 3708 5 0 6
GSE74703 ITPR1 3708 0 18 18
GSE74704 ITPR1 3708 1 11 8
TCGA ITPR1 3708 2 67 27

Total number of gains: 21; Total number of losses: 229; Total Number of normals: 238.  

 

Somatic mutations of ITPR1:

 

Generating mutation plots.

 

Highly correlated genes for ITPR1:

 

Showing top 20/1190 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ITPR1C1QTNF70.8226505
ITPR1LRFN50.822271404
ITPR1ZNF5400.818218303
ITPR1AFF30.807225303
ITPR1MIER10.797547303
ITPR1CADM30.793034404
ITPR1CFL20.791935505
ITPR1CLEC3B0.790723303
ITPR1XKR40.784952505
ITPR1GNG70.783862606
ITPR1TMEM132C0.781212303
ITPR1SMTN0.781118606
ITPR1RNF1500.778406606
ITPR1RAI20.773469707
ITPR1BCAS20.772836303
ITPR1CBX70.76468807
ITPR1BCHE0.764397808
ITPR1BTD0.757949505
ITPR1FXYD10.755817606
ITPR1ASPA0.755541908

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