| Full name: angiopoietin like 1 | Alias Symbol: ANG3|AngY|ARP1 | ||
| Type: protein-coding gene | Cytoband: 1q25.2 | ||
| Entrez ID: 9068 | HGNC ID: HGNC:489 | Ensembl Gene: ENSG00000116194 | OMIM ID: 603874 |
| Drug and gene relationship at DGIdb | |||
Expression of ANGPTL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ANGPTL1 | 9068 | 231773_at | -2.4024 | 0.0559 | |
| GSE26886 | ANGPTL1 | 9068 | 224339_s_at | 0.0220 | 0.9160 | |
| GSE45670 | ANGPTL1 | 9068 | 224339_s_at | -2.3395 | 0.0000 | |
| GSE53622 | ANGPTL1 | 9068 | 119269 | -3.3568 | 0.0000 | |
| GSE53624 | ANGPTL1 | 9068 | 119269 | -3.0657 | 0.0000 | |
| GSE63941 | ANGPTL1 | 9068 | 224339_s_at | -1.6528 | 0.0003 | |
| GSE77861 | ANGPTL1 | 9068 | 224339_s_at | -0.0113 | 0.8975 | |
| GSE97050 | ANGPTL1 | 9068 | A_23_P126706 | -1.7441 | 0.1095 | |
| SRP064894 | ANGPTL1 | 9068 | RNAseq | -0.7571 | 0.2017 | |
| SRP133303 | ANGPTL1 | 9068 | RNAseq | -1.4390 | 0.0003 | |
| SRP159526 | ANGPTL1 | 9068 | RNAseq | -2.5427 | 0.0010 | |
| SRP193095 | ANGPTL1 | 9068 | RNAseq | -1.1385 | 0.0000 | |
| SRP219564 | ANGPTL1 | 9068 | RNAseq | -1.2909 | 0.2735 | |
| TCGA | ANGPTL1 | 9068 | RNAseq | -1.5595 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 8.
Survival by ANGPTL1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of ANGPTL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ANGPTL1 | 9068 | 12 | 0 | 18 | |
| GSE20123 | ANGPTL1 | 9068 | 12 | 0 | 18 | |
| GSE43470 | ANGPTL1 | 9068 | 9 | 1 | 33 | |
| GSE46452 | ANGPTL1 | 9068 | 3 | 1 | 55 | |
| GSE47630 | ANGPTL1 | 9068 | 14 | 0 | 26 | |
| GSE54993 | ANGPTL1 | 9068 | 0 | 6 | 64 | |
| GSE54994 | ANGPTL1 | 9068 | 15 | 0 | 38 | |
| GSE60625 | ANGPTL1 | 9068 | 0 | 0 | 11 | |
| GSE74703 | ANGPTL1 | 9068 | 8 | 1 | 27 | |
| GSE74704 | ANGPTL1 | 9068 | 5 | 0 | 15 | |
| TCGA | ANGPTL1 | 9068 | 40 | 4 | 52 |
Total number of gains: 118; Total number of losses: 13; Total Number of normals: 357.
Somatic mutations of ANGPTL1:
Generating mutation plots.
Highly correlated genes for ANGPTL1:
Showing top 20/1398 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ANGPTL1 | CLEC3B | 0.899345 | 3 | 0 | 3 |
| ANGPTL1 | CASQ2 | 0.897561 | 6 | 0 | 6 |
| ANGPTL1 | PGM5 | 0.89466 | 5 | 0 | 5 |
| ANGPTL1 | CACNB2 | 0.890844 | 5 | 0 | 5 |
| ANGPTL1 | RERGL | 0.889593 | 5 | 0 | 5 |
| ANGPTL1 | NPY1R | 0.888608 | 3 | 0 | 3 |
| ANGPTL1 | C7 | 0.88163 | 6 | 0 | 6 |
| ANGPTL1 | APOD | 0.872755 | 5 | 0 | 5 |
| ANGPTL1 | CYP21A2 | 0.870584 | 3 | 0 | 3 |
| ANGPTL1 | SLIT3 | 0.862891 | 4 | 0 | 4 |
| ANGPTL1 | LMOD1 | 0.857325 | 7 | 0 | 7 |
| ANGPTL1 | SGCA | 0.85641 | 5 | 0 | 5 |
| ANGPTL1 | PDE5A | 0.852843 | 6 | 0 | 6 |
| ANGPTL1 | OGN | 0.851275 | 7 | 0 | 7 |
| ANGPTL1 | FAM13C | 0.850611 | 4 | 0 | 4 |
| ANGPTL1 | ABCA6 | 0.850288 | 6 | 0 | 6 |
| ANGPTL1 | EIF4E3 | 0.848651 | 5 | 0 | 5 |
| ANGPTL1 | SORBS2 | 0.848603 | 5 | 0 | 5 |
| ANGPTL1 | NFIA | 0.846484 | 5 | 0 | 5 |
| ANGPTL1 | SLITRK3 | 0.842237 | 6 | 0 | 6 |
For details and further investigation, click here
