| Full name: methionine sulfoxide reductase B3 | Alias Symbol: FLJ36866|DKFZp686C1178 | ||
| Type: protein-coding gene | Cytoband: 12q14.3 | ||
| Entrez ID: 253827 | HGNC ID: HGNC:27375 | Ensembl Gene: ENSG00000174099 | OMIM ID: 613719 |
| Drug and gene relationship at DGIdb | |||
Expression of MSRB3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MSRB3 | 253827 | 225782_at | -2.0806 | 0.1621 | |
| GSE26886 | MSRB3 | 253827 | 1554126_at | -0.0456 | 0.7660 | |
| GSE45670 | MSRB3 | 253827 | 225782_at | -3.4539 | 0.0000 | |
| GSE53622 | MSRB3 | 253827 | 90674 | -1.2609 | 0.0000 | |
| GSE53624 | MSRB3 | 253827 | 90674 | -1.1122 | 0.0000 | |
| GSE63941 | MSRB3 | 253827 | 1554126_at | -1.0574 | 0.0011 | |
| GSE77861 | MSRB3 | 253827 | 1554126_at | -0.1133 | 0.2781 | |
| GSE97050 | MSRB3 | 253827 | A_33_P3278313 | -1.3285 | 0.0828 | |
| SRP007169 | MSRB3 | 253827 | RNAseq | 3.2095 | 0.0000 | |
| SRP008496 | MSRB3 | 253827 | RNAseq | 3.8239 | 0.0000 | |
| SRP064894 | MSRB3 | 253827 | RNAseq | -0.5719 | 0.0882 | |
| SRP133303 | MSRB3 | 253827 | RNAseq | -0.1291 | 0.7892 | |
| SRP159526 | MSRB3 | 253827 | RNAseq | -1.0868 | 0.0370 | |
| SRP193095 | MSRB3 | 253827 | RNAseq | 0.8925 | 0.0137 | |
| SRP219564 | MSRB3 | 253827 | RNAseq | -0.7946 | 0.4304 | |
| TCGA | MSRB3 | 253827 | RNAseq | -0.4817 | 0.0008 |
Upregulated datasets: 2; Downregulated datasets: 5.
Survival by MSRB3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MSRB3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MSRB3 | 253827 | 5 | 1 | 24 | |
| GSE20123 | MSRB3 | 253827 | 5 | 1 | 24 | |
| GSE43470 | MSRB3 | 253827 | 5 | 0 | 38 | |
| GSE46452 | MSRB3 | 253827 | 13 | 0 | 46 | |
| GSE47630 | MSRB3 | 253827 | 10 | 1 | 29 | |
| GSE54993 | MSRB3 | 253827 | 0 | 7 | 63 | |
| GSE54994 | MSRB3 | 253827 | 6 | 1 | 46 | |
| GSE60625 | MSRB3 | 253827 | 0 | 0 | 11 | |
| GSE74703 | MSRB3 | 253827 | 5 | 0 | 31 | |
| GSE74704 | MSRB3 | 253827 | 4 | 1 | 15 | |
| TCGA | MSRB3 | 253827 | 22 | 9 | 65 |
Total number of gains: 75; Total number of losses: 21; Total Number of normals: 392.
Somatic mutations of MSRB3:
Generating mutation plots.
Highly correlated genes for MSRB3:
Showing top 20/1033 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MSRB3 | TMEM47 | 0.888127 | 7 | 0 | 7 |
| MSRB3 | DIXDC1 | 0.880929 | 6 | 0 | 6 |
| MSRB3 | JAM3 | 0.878464 | 7 | 0 | 7 |
| MSRB3 | PDLIM3 | 0.868259 | 7 | 0 | 7 |
| MSRB3 | NEXN | 0.86146 | 7 | 0 | 7 |
| MSRB3 | UBXN10 | 0.859248 | 3 | 0 | 3 |
| MSRB3 | RUNX1T1 | 0.858775 | 5 | 0 | 5 |
| MSRB3 | DDR2 | 0.858602 | 7 | 0 | 7 |
| MSRB3 | ITGA9 | 0.854613 | 5 | 0 | 5 |
| MSRB3 | ACTA2 | 0.849267 | 7 | 0 | 7 |
| MSRB3 | MAGI2-AS3 | 0.84736 | 5 | 0 | 5 |
| MSRB3 | CNN1 | 0.845385 | 5 | 0 | 5 |
| MSRB3 | CHRDL1 | 0.845357 | 4 | 0 | 4 |
| MSRB3 | NFASC | 0.844721 | 4 | 0 | 4 |
| MSRB3 | SATB1 | 0.838257 | 3 | 0 | 3 |
| MSRB3 | ACTG2 | 0.836645 | 7 | 0 | 7 |
| MSRB3 | LRFN5 | 0.834741 | 4 | 0 | 4 |
| MSRB3 | TCEAL5 | 0.833933 | 3 | 0 | 3 |
| MSRB3 | MRGPRF | 0.826648 | 7 | 0 | 7 |
| MSRB3 | SLITRK3 | 0.824177 | 5 | 0 | 5 |
For details and further investigation, click here
