| Full name: mediator complex subunit 7 | Alias Symbol: CRSP33 | ||
| Type: protein-coding gene | Cytoband: 5q33.3 | ||
| Entrez ID: 9443 | HGNC ID: HGNC:2378 | Ensembl Gene: ENSG00000155868 | OMIM ID: 605045 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of MED7:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | MED7 | 9443 | 204350_s_at | -0.5052 | 0.0756 | |
| GSE20347 | MED7 | 9443 | 204349_at | -0.5849 | 0.0009 | |
| GSE23400 | MED7 | 9443 | 204350_s_at | -0.0686 | 0.0565 | |
| GSE26886 | MED7 | 9443 | 204349_at | -0.4203 | 0.0701 | |
| GSE29001 | MED7 | 9443 | 204349_at | -0.2505 | 0.3660 | |
| GSE38129 | MED7 | 9443 | 204349_at | -0.4275 | 0.0010 | |
| GSE45670 | MED7 | 9443 | 204349_at | -0.1655 | 0.2849 | |
| GSE53622 | MED7 | 9443 | 49037 | -0.5686 | 0.0000 | |
| GSE53624 | MED7 | 9443 | 49037 | -0.3862 | 0.0000 | |
| GSE63941 | MED7 | 9443 | 204350_s_at | 0.3860 | 0.2143 | |
| GSE77861 | MED7 | 9443 | 204350_s_at | -0.1614 | 0.4740 | |
| GSE97050 | MED7 | 9443 | A_23_P30307 | -0.2587 | 0.3023 | |
| SRP007169 | MED7 | 9443 | RNAseq | -1.2375 | 0.0008 | |
| SRP008496 | MED7 | 9443 | RNAseq | -1.0042 | 0.0003 | |
| SRP064894 | MED7 | 9443 | RNAseq | -0.3303 | 0.0330 | |
| SRP133303 | MED7 | 9443 | RNAseq | -0.3129 | 0.0496 | |
| SRP159526 | MED7 | 9443 | RNAseq | -0.4197 | 0.1211 | |
| SRP193095 | MED7 | 9443 | RNAseq | -0.6513 | 0.0000 | |
| SRP219564 | MED7 | 9443 | RNAseq | -0.2652 | 0.2450 | |
| TCGA | MED7 | 9443 | RNAseq | -0.1886 | 0.0040 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by MED7 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of MED7:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | MED7 | 9443 | 0 | 11 | 19 | |
| GSE20123 | MED7 | 9443 | 0 | 11 | 19 | |
| GSE43470 | MED7 | 9443 | 2 | 11 | 30 | |
| GSE46452 | MED7 | 9443 | 0 | 27 | 32 | |
| GSE47630 | MED7 | 9443 | 0 | 20 | 20 | |
| GSE54993 | MED7 | 9443 | 9 | 1 | 60 | |
| GSE54994 | MED7 | 9443 | 1 | 16 | 36 | |
| GSE60625 | MED7 | 9443 | 0 | 0 | 11 | |
| GSE74703 | MED7 | 9443 | 2 | 8 | 26 | |
| GSE74704 | MED7 | 9443 | 0 | 6 | 14 | |
| TCGA | MED7 | 9443 | 4 | 36 | 56 |
Total number of gains: 18; Total number of losses: 147; Total Number of normals: 323.
Somatic mutations of MED7:
Generating mutation plots.
Highly correlated genes for MED7:
Showing top 20/855 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| MED7 | GNG7 | 0.772183 | 3 | 0 | 3 |
| MED7 | NLGN4Y | 0.755188 | 3 | 0 | 3 |
| MED7 | PHYHD1 | 0.75513 | 3 | 0 | 3 |
| MED7 | BRD8 | 0.754417 | 4 | 0 | 4 |
| MED7 | CBLL1 | 0.74052 | 3 | 0 | 3 |
| MED7 | FBXL3 | 0.736142 | 3 | 0 | 3 |
| MED7 | HNRNPA0 | 0.735018 | 3 | 0 | 3 |
| MED7 | MAP4K5 | 0.731969 | 3 | 0 | 3 |
| MED7 | ZNF564 | 0.731262 | 3 | 0 | 3 |
| MED7 | EAF1 | 0.72952 | 3 | 0 | 3 |
| MED7 | PDHX | 0.727703 | 3 | 0 | 3 |
| MED7 | EXOC6B | 0.726312 | 3 | 0 | 3 |
| MED7 | ANKRA2 | 0.718582 | 6 | 0 | 6 |
| MED7 | MAP4K3 | 0.717609 | 3 | 0 | 3 |
| MED7 | PDE7B | 0.717167 | 3 | 0 | 3 |
| MED7 | RGS7BP | 0.716452 | 3 | 0 | 3 |
| MED7 | PCNP | 0.715328 | 5 | 0 | 4 |
| MED7 | UBE3A | 0.71248 | 3 | 0 | 3 |
| MED7 | RNF185 | 0.711556 | 4 | 0 | 4 |
| MED7 | ESYT2 | 0.71014 | 3 | 0 | 3 |
For details and further investigation, click here
