| Full name: cytochrome P450 family 21 subfamily A member 2 | Alias Symbol: P450c21B|CA21H|CPS1|CAH1 | ||
| Type: protein-coding gene | Cytoband: 6p21.33 | ||
| Entrez ID: 1589 | HGNC ID: HGNC:2600 | Ensembl Gene: ENSG00000231852 | OMIM ID: 613815 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP21A2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | CYP21A2 | 1589 | 107170 | -2.2473 | 0.0000 | |
| GSE53624 | CYP21A2 | 1589 | 107170 | -2.3747 | 0.0000 | |
| GSE97050 | CYP21A2 | 1589 | A_23_P257478 | -0.6643 | 0.2385 | |
| TCGA | CYP21A2 | 1589 | RNAseq | -1.2687 | 0.0197 |
Upregulated datasets: 0; Downregulated datasets: 3.
Survival by CYP21A2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CYP21A2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP21A2 | 1589 | 5 | 1 | 24 | |
| GSE20123 | CYP21A2 | 1589 | 5 | 1 | 24 | |
| GSE43470 | CYP21A2 | 1589 | 5 | 1 | 37 | |
| GSE46452 | CYP21A2 | 1589 | 1 | 10 | 48 | |
| GSE47630 | CYP21A2 | 1589 | 7 | 4 | 29 | |
| GSE54993 | CYP21A2 | 1589 | 2 | 1 | 67 | |
| GSE54994 | CYP21A2 | 1589 | 11 | 4 | 38 | |
| GSE60625 | CYP21A2 | 1589 | 0 | 1 | 10 | |
| GSE74703 | CYP21A2 | 1589 | 5 | 0 | 31 | |
| GSE74704 | CYP21A2 | 1589 | 2 | 0 | 18 | |
| TCGA | CYP21A2 | 1589 | 16 | 16 | 64 |
Total number of gains: 59; Total number of losses: 39; Total Number of normals: 390.
Somatic mutations of CYP21A2:
Generating mutation plots.
Highly correlated genes for CYP21A2:
Showing top 20/679 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP21A2 | CLEC3B | 0.925927 | 3 | 0 | 3 |
| CYP21A2 | CFD | 0.909058 | 3 | 0 | 3 |
| CYP21A2 | PLAC9 | 0.90807 | 3 | 0 | 3 |
| CYP21A2 | RCAN2 | 0.905259 | 3 | 0 | 3 |
| CYP21A2 | PI16 | 0.898473 | 3 | 0 | 3 |
| CYP21A2 | SORCS1 | 0.885012 | 3 | 0 | 3 |
| CYP21A2 | F10 | 0.883564 | 3 | 0 | 3 |
| CYP21A2 | CCDC69 | 0.882908 | 3 | 0 | 3 |
| CYP21A2 | PYGM | 0.873736 | 3 | 0 | 3 |
| CYP21A2 | HSPB6 | 0.872966 | 3 | 0 | 3 |
| CYP21A2 | PGM5 | 0.872843 | 3 | 0 | 3 |
| CYP21A2 | AQP1 | 0.870974 | 3 | 0 | 3 |
| CYP21A2 | ANGPTL1 | 0.870584 | 3 | 0 | 3 |
| CYP21A2 | ARHGAP6 | 0.87043 | 3 | 0 | 3 |
| CYP21A2 | TNS1 | 0.87035 | 3 | 0 | 3 |
| CYP21A2 | ATP1B2 | 0.869136 | 3 | 0 | 3 |
| CYP21A2 | ATP1A2 | 0.867025 | 3 | 0 | 3 |
| CYP21A2 | XKR4 | 0.866525 | 3 | 0 | 3 |
| CYP21A2 | ASPA | 0.866347 | 3 | 0 | 3 |
| CYP21A2 | SGCA | 0.864581 | 3 | 0 | 3 |
For details and further investigation, click here
