| Full name: hexosaminidase subunit beta | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 5q13.3 | ||
| Entrez ID: 3074 | HGNC ID: HGNC:4879 | Ensembl Gene: ENSG00000049860 | OMIM ID: 606873 |
| Drug and gene relationship at DGIdb | |||
Expression of HEXB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HEXB | 3074 | 201944_at | 0.0154 | 0.9875 | |
| GSE20347 | HEXB | 3074 | 201944_at | 0.6616 | 0.0000 | |
| GSE23400 | HEXB | 3074 | 201944_at | 0.7885 | 0.0000 | |
| GSE26886 | HEXB | 3074 | 201944_at | 1.1853 | 0.0000 | |
| GSE29001 | HEXB | 3074 | 201944_at | 0.7253 | 0.0236 | |
| GSE38129 | HEXB | 3074 | 201944_at | 0.6456 | 0.0003 | |
| GSE45670 | HEXB | 3074 | 201944_at | 0.2051 | 0.4415 | |
| GSE53622 | HEXB | 3074 | 25964 | 0.6069 | 0.0000 | |
| GSE53624 | HEXB | 3074 | 39795 | 0.8873 | 0.0000 | |
| GSE63941 | HEXB | 3074 | 201944_at | -1.2670 | 0.0010 | |
| GSE77861 | HEXB | 3074 | 201944_at | 0.8371 | 0.0452 | |
| GSE97050 | HEXB | 3074 | A_23_P156049 | 0.4990 | 0.1280 | |
| SRP007169 | HEXB | 3074 | RNAseq | 1.9231 | 0.0000 | |
| SRP008496 | HEXB | 3074 | RNAseq | 1.6723 | 0.0000 | |
| SRP064894 | HEXB | 3074 | RNAseq | 0.9169 | 0.0000 | |
| SRP133303 | HEXB | 3074 | RNAseq | 0.8366 | 0.0000 | |
| SRP159526 | HEXB | 3074 | RNAseq | 0.7789 | 0.0325 | |
| SRP193095 | HEXB | 3074 | RNAseq | 0.2414 | 0.2843 | |
| SRP219564 | HEXB | 3074 | RNAseq | 0.6674 | 0.1790 | |
| TCGA | HEXB | 3074 | RNAseq | -0.0370 | 0.4378 |
Upregulated datasets: 3; Downregulated datasets: 1.
Survival by HEXB expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HEXB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HEXB | 3074 | 1 | 13 | 16 | |
| GSE20123 | HEXB | 3074 | 1 | 13 | 16 | |
| GSE43470 | HEXB | 3074 | 1 | 13 | 29 | |
| GSE46452 | HEXB | 3074 | 0 | 28 | 31 | |
| GSE47630 | HEXB | 3074 | 1 | 19 | 20 | |
| GSE54993 | HEXB | 3074 | 8 | 1 | 61 | |
| GSE54994 | HEXB | 3074 | 1 | 19 | 33 | |
| GSE60625 | HEXB | 3074 | 0 | 0 | 11 | |
| GSE74703 | HEXB | 3074 | 1 | 9 | 26 | |
| GSE74704 | HEXB | 3074 | 1 | 6 | 13 | |
| TCGA | HEXB | 3074 | 5 | 50 | 41 |
Total number of gains: 20; Total number of losses: 171; Total Number of normals: 297.
Somatic mutations of HEXB:
Generating mutation plots.
Highly correlated genes for HEXB:
Showing top 20/1494 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HEXB | WDR81 | 0.813924 | 3 | 0 | 3 |
| HEXB | KRTCAP2 | 0.770529 | 4 | 0 | 4 |
| HEXB | SLC43A3 | 0.767771 | 3 | 0 | 3 |
| HEXB | GRAMD1A | 0.76737 | 6 | 0 | 6 |
| HEXB | TTI2 | 0.751604 | 3 | 0 | 3 |
| HEXB | C11orf96 | 0.749145 | 3 | 0 | 3 |
| HEXB | RAPGEF6 | 0.744099 | 5 | 0 | 5 |
| HEXB | RAB34 | 0.739768 | 3 | 0 | 3 |
| HEXB | FADS1 | 0.738929 | 3 | 0 | 3 |
| HEXB | CCM2 | 0.738805 | 6 | 0 | 6 |
| HEXB | LHFPL2 | 0.738519 | 13 | 0 | 13 |
| HEXB | TIMP1 | 0.737817 | 11 | 0 | 11 |
| HEXB | GPX8 | 0.735371 | 8 | 0 | 8 |
| HEXB | RILPL1 | 0.734324 | 4 | 0 | 4 |
| HEXB | SGTB | 0.729997 | 6 | 0 | 6 |
| HEXB | B3GALT6 | 0.728787 | 5 | 0 | 5 |
| HEXB | PLOD1 | 0.726209 | 11 | 0 | 11 |
| HEXB | TMEM263 | 0.725542 | 6 | 0 | 6 |
| HEXB | ATP11C | 0.72459 | 5 | 0 | 5 |
| HEXB | SLC39A13 | 0.724104 | 7 | 0 | 7 |
For details and further investigation, click here
