| Full name: LHFPL tetraspan subfamily member 2 | Alias Symbol: KIAA0206 | ||
| Type: protein-coding gene | Cytoband: 5q14.1 | ||
| Entrez ID: 10184 | HGNC ID: HGNC:6588 | Ensembl Gene: ENSG00000145685 | OMIM ID: 609718 |
| Drug and gene relationship at DGIdb | |||
Expression of LHFPL2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LHFPL2 | 10184 | 212658_at | 0.7399 | 0.1301 | |
| GSE20347 | LHFPL2 | 10184 | 212658_at | 0.8058 | 0.0000 | |
| GSE23400 | LHFPL2 | 10184 | 212658_at | 0.3515 | 0.0000 | |
| GSE26886 | LHFPL2 | 10184 | 212658_at | 1.6882 | 0.0000 | |
| GSE29001 | LHFPL2 | 10184 | 212658_at | 1.0736 | 0.0016 | |
| GSE38129 | LHFPL2 | 10184 | 212658_at | 0.6515 | 0.0004 | |
| GSE45670 | LHFPL2 | 10184 | 212658_at | 0.2777 | 0.3329 | |
| GSE53622 | LHFPL2 | 10184 | 12422 | 1.1104 | 0.0000 | |
| GSE53624 | LHFPL2 | 10184 | 12422 | 1.3767 | 0.0000 | |
| GSE63941 | LHFPL2 | 10184 | 212658_at | -3.3175 | 0.0000 | |
| GSE77861 | LHFPL2 | 10184 | 212658_at | 0.7101 | 0.0020 | |
| GSE97050 | LHFPL2 | 10184 | A_23_P255104 | 0.4389 | 0.2709 | |
| SRP007169 | LHFPL2 | 10184 | RNAseq | 3.7157 | 0.0000 | |
| SRP008496 | LHFPL2 | 10184 | RNAseq | 3.7567 | 0.0000 | |
| SRP064894 | LHFPL2 | 10184 | RNAseq | 1.7070 | 0.0000 | |
| SRP133303 | LHFPL2 | 10184 | RNAseq | 1.5527 | 0.0000 | |
| SRP159526 | LHFPL2 | 10184 | RNAseq | 1.2644 | 0.0001 | |
| SRP193095 | LHFPL2 | 10184 | RNAseq | 1.0267 | 0.0038 | |
| SRP219564 | LHFPL2 | 10184 | RNAseq | 1.3617 | 0.0213 | |
| TCGA | LHFPL2 | 10184 | RNAseq | -0.1204 | 0.1177 |
Upregulated datasets: 11; Downregulated datasets: 1.
Survival by LHFPL2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LHFPL2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LHFPL2 | 10184 | 1 | 13 | 16 | |
| GSE20123 | LHFPL2 | 10184 | 1 | 13 | 16 | |
| GSE43470 | LHFPL2 | 10184 | 1 | 13 | 29 | |
| GSE46452 | LHFPL2 | 10184 | 0 | 28 | 31 | |
| GSE47630 | LHFPL2 | 10184 | 1 | 19 | 20 | |
| GSE54993 | LHFPL2 | 10184 | 8 | 1 | 61 | |
| GSE54994 | LHFPL2 | 10184 | 1 | 19 | 33 | |
| GSE60625 | LHFPL2 | 10184 | 0 | 0 | 11 | |
| GSE74703 | LHFPL2 | 10184 | 1 | 9 | 26 | |
| GSE74704 | LHFPL2 | 10184 | 1 | 6 | 13 | |
| TCGA | LHFPL2 | 10184 | 4 | 50 | 42 |
Total number of gains: 19; Total number of losses: 171; Total Number of normals: 298.
Somatic mutations of LHFPL2:
Generating mutation plots.
Highly correlated genes for LHFPL2:
Showing top 20/1605 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LHFPL2 | FCGR3A | 0.861211 | 3 | 0 | 3 |
| LHFPL2 | TMEM263 | 0.774808 | 7 | 0 | 7 |
| LHFPL2 | VCAN | 0.762513 | 13 | 0 | 12 |
| LHFPL2 | TIMP1 | 0.76175 | 12 | 0 | 12 |
| LHFPL2 | TMC8 | 0.757329 | 3 | 0 | 3 |
| LHFPL2 | MMD | 0.754212 | 13 | 0 | 12 |
| LHFPL2 | CALU | 0.749934 | 12 | 0 | 11 |
| LHFPL2 | TNFAIP6 | 0.748892 | 13 | 0 | 13 |
| LHFPL2 | LOXL2 | 0.746915 | 12 | 0 | 12 |
| LHFPL2 | FNDC3B | 0.745817 | 12 | 0 | 12 |
| LHFPL2 | GPX8 | 0.745771 | 8 | 0 | 8 |
| LHFPL2 | ACVR1 | 0.743269 | 12 | 0 | 12 |
| LHFPL2 | C1orf216 | 0.742673 | 12 | 0 | 12 |
| LHFPL2 | CSGALNACT2 | 0.741148 | 12 | 0 | 12 |
| LHFPL2 | LPCAT1 | 0.739835 | 11 | 0 | 11 |
| LHFPL2 | HEXB | 0.738519 | 13 | 0 | 13 |
| LHFPL2 | SLC41A1 | 0.736982 | 7 | 0 | 7 |
| LHFPL2 | ANGPT2 | 0.735347 | 7 | 0 | 7 |
| LHFPL2 | CTSL | 0.73262 | 11 | 0 | 11 |
| LHFPL2 | SLC25A32 | 0.732518 | 11 | 0 | 10 |
For details and further investigation, click here
