| Full name: glutathione peroxidase 8 (putative) | Alias Symbol: UNQ847|EPLA847 | ||
| Type: protein-coding gene | Cytoband: 5q11.2 | ||
| Entrez ID: 493869 | HGNC ID: HGNC:33100 | Ensembl Gene: ENSG00000164294 | OMIM ID: 617172 |
| Drug and gene relationship at DGIdb | |||
Expression of GPX8:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPX8 | 493869 | 227628_at | 0.8855 | 0.3760 | |
| GSE26886 | GPX8 | 493869 | 227628_at | 2.5270 | 0.0000 | |
| GSE45670 | GPX8 | 493869 | 227628_at | 0.6807 | 0.2051 | |
| GSE53622 | GPX8 | 493869 | 106212 | 1.1422 | 0.0000 | |
| GSE53624 | GPX8 | 493869 | 106212 | 1.5013 | 0.0000 | |
| GSE63941 | GPX8 | 493869 | 227628_at | -1.7381 | 0.0075 | |
| GSE77861 | GPX8 | 493869 | 227628_at | 0.6802 | 0.2241 | |
| GSE97050 | GPX8 | 493869 | A_23_P122052 | 0.6593 | 0.1310 | |
| SRP007169 | GPX8 | 493869 | RNAseq | 2.0554 | 0.0000 | |
| SRP008496 | GPX8 | 493869 | RNAseq | 2.4065 | 0.0000 | |
| SRP064894 | GPX8 | 493869 | RNAseq | 1.6639 | 0.0000 | |
| SRP133303 | GPX8 | 493869 | RNAseq | 1.2746 | 0.0000 | |
| SRP159526 | GPX8 | 493869 | RNAseq | 1.3634 | 0.0082 | |
| SRP193095 | GPX8 | 493869 | RNAseq | 1.4243 | 0.0000 | |
| SRP219564 | GPX8 | 493869 | RNAseq | 1.4761 | 0.0279 | |
| TCGA | GPX8 | 493869 | RNAseq | 0.2285 | 0.0217 |
Upregulated datasets: 10; Downregulated datasets: 1.
Survival by GPX8 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPX8:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPX8 | 493869 | 1 | 13 | 16 | |
| GSE20123 | GPX8 | 493869 | 1 | 13 | 16 | |
| GSE43470 | GPX8 | 493869 | 1 | 12 | 30 | |
| GSE46452 | GPX8 | 493869 | 1 | 27 | 31 | |
| GSE47630 | GPX8 | 493869 | 2 | 16 | 22 | |
| GSE54993 | GPX8 | 493869 | 8 | 1 | 61 | |
| GSE54994 | GPX8 | 493869 | 3 | 20 | 30 | |
| GSE60625 | GPX8 | 493869 | 0 | 0 | 11 | |
| GSE74703 | GPX8 | 493869 | 1 | 9 | 26 | |
| GSE74704 | GPX8 | 493869 | 1 | 6 | 13 | |
| TCGA | GPX8 | 493869 | 8 | 45 | 43 |
Total number of gains: 27; Total number of losses: 162; Total Number of normals: 299.
Somatic mutations of GPX8:
Generating mutation plots.
Highly correlated genes for GPX8:
Showing top 20/1273 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPX8 | SPON2 | 0.800339 | 3 | 0 | 3 |
| GPX8 | PDIA5 | 0.797172 | 3 | 0 | 3 |
| GPX8 | MFAP2 | 0.794202 | 7 | 0 | 7 |
| GPX8 | FNDC3B | 0.78751 | 7 | 0 | 7 |
| GPX8 | LRRC8C | 0.782349 | 3 | 0 | 3 |
| GPX8 | TMEM263 | 0.778457 | 6 | 0 | 6 |
| GPX8 | GNA12 | 0.769235 | 7 | 0 | 7 |
| GPX8 | FKBP7 | 0.766201 | 6 | 0 | 6 |
| GPX8 | RAB34 | 0.763215 | 3 | 0 | 3 |
| GPX8 | LPCAT1 | 0.755252 | 7 | 0 | 6 |
| GPX8 | COL5A1 | 0.755121 | 9 | 0 | 8 |
| GPX8 | CDH11 | 0.749658 | 8 | 0 | 7 |
| GPX8 | CTHRC1 | 0.749254 | 8 | 0 | 8 |
| GPX8 | ACVR1 | 0.74703 | 8 | 0 | 8 |
| GPX8 | LHFPL2 | 0.745771 | 8 | 0 | 8 |
| GPX8 | COL5A2 | 0.745503 | 9 | 0 | 8 |
| GPX8 | KDELR3 | 0.744037 | 8 | 0 | 8 |
| GPX8 | VCAN | 0.743851 | 8 | 0 | 8 |
| GPX8 | GALNT10 | 0.742198 | 7 | 0 | 7 |
| GPX8 | LOXL2 | 0.738839 | 8 | 0 | 8 |
For details and further investigation, click here
