| Full name: procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 | Alias Symbol: LH1 | ||
| Type: protein-coding gene | Cytoband: 1p36.22 | ||
| Entrez ID: 5351 | HGNC ID: HGNC:9081 | Ensembl Gene: ENSG00000083444 | OMIM ID: 153454 |
| Drug and gene relationship at DGIdb | |||
Expression of PLOD1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PLOD1 | 5351 | 200827_at | 1.0460 | 0.0086 | |
| GSE20347 | PLOD1 | 5351 | 200827_at | 1.0303 | 0.0000 | |
| GSE23400 | PLOD1 | 5351 | 200827_at | 0.9569 | 0.0000 | |
| GSE26886 | PLOD1 | 5351 | 200827_at | 1.4188 | 0.0000 | |
| GSE29001 | PLOD1 | 5351 | 200827_at | 1.1364 | 0.0002 | |
| GSE38129 | PLOD1 | 5351 | 200827_at | 0.9840 | 0.0000 | |
| GSE45670 | PLOD1 | 5351 | 200827_at | 0.9805 | 0.0009 | |
| GSE53622 | PLOD1 | 5351 | 27195 | 1.5836 | 0.0000 | |
| GSE53624 | PLOD1 | 5351 | 108257 | 1.7775 | 0.0000 | |
| GSE63941 | PLOD1 | 5351 | 200827_at | -1.2009 | 0.0648 | |
| GSE77861 | PLOD1 | 5351 | 200827_at | 0.3569 | 0.2293 | |
| GSE97050 | PLOD1 | 5351 | A_33_P3358824 | 1.0852 | 0.0631 | |
| SRP007169 | PLOD1 | 5351 | RNAseq | 1.7682 | 0.0001 | |
| SRP008496 | PLOD1 | 5351 | RNAseq | 1.8921 | 0.0000 | |
| SRP064894 | PLOD1 | 5351 | RNAseq | 2.2916 | 0.0000 | |
| SRP133303 | PLOD1 | 5351 | RNAseq | 1.7298 | 0.0000 | |
| SRP159526 | PLOD1 | 5351 | RNAseq | 1.8191 | 0.0002 | |
| SRP193095 | PLOD1 | 5351 | RNAseq | 2.0069 | 0.0000 | |
| SRP219564 | PLOD1 | 5351 | RNAseq | 1.0127 | 0.0930 | |
| TCGA | PLOD1 | 5351 | RNAseq | 0.2563 | 0.0001 |
Upregulated datasets: 12; Downregulated datasets: 0.
Survival by PLOD1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PLOD1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PLOD1 | 5351 | 0 | 5 | 25 | |
| GSE20123 | PLOD1 | 5351 | 0 | 4 | 26 | |
| GSE43470 | PLOD1 | 5351 | 4 | 6 | 33 | |
| GSE46452 | PLOD1 | 5351 | 7 | 1 | 51 | |
| GSE47630 | PLOD1 | 5351 | 8 | 4 | 28 | |
| GSE54993 | PLOD1 | 5351 | 3 | 1 | 66 | |
| GSE54994 | PLOD1 | 5351 | 11 | 4 | 38 | |
| GSE60625 | PLOD1 | 5351 | 0 | 0 | 11 | |
| GSE74703 | PLOD1 | 5351 | 3 | 4 | 29 | |
| GSE74704 | PLOD1 | 5351 | 0 | 0 | 20 | |
| TCGA | PLOD1 | 5351 | 11 | 22 | 63 |
Total number of gains: 47; Total number of losses: 51; Total Number of normals: 390.
Somatic mutations of PLOD1:
Generating mutation plots.
Highly correlated genes for PLOD1:
Showing top 20/2007 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PLOD1 | TP53I13 | 0.83044 | 6 | 0 | 6 |
| PLOD1 | LPCAT1 | 0.822481 | 12 | 0 | 12 |
| PLOD1 | FADS1 | 0.820178 | 3 | 0 | 3 |
| PLOD1 | FNDC3B | 0.818776 | 11 | 0 | 11 |
| PLOD1 | SPON2 | 0.805833 | 3 | 0 | 3 |
| PLOD1 | RAB34 | 0.800433 | 3 | 0 | 3 |
| PLOD1 | CD276 | 0.77599 | 5 | 0 | 5 |
| PLOD1 | PDE7A | 0.775927 | 7 | 0 | 7 |
| PLOD1 | WDR54 | 0.774107 | 7 | 0 | 7 |
| PLOD1 | SLC39A3 | 0.773662 | 4 | 0 | 4 |
| PLOD1 | FMNL2 | 0.772722 | 7 | 0 | 7 |
| PLOD1 | LOXL2 | 0.770754 | 12 | 0 | 12 |
| PLOD1 | PLAU | 0.770376 | 11 | 0 | 11 |
| PLOD1 | PLOD3 | 0.769356 | 13 | 0 | 11 |
| PLOD1 | SERPINH1 | 0.766422 | 12 | 0 | 11 |
| PLOD1 | LIX1L | 0.765559 | 4 | 0 | 4 |
| PLOD1 | PSMB2 | 0.764199 | 10 | 0 | 10 |
| PLOD1 | DHRS13 | 0.755759 | 3 | 0 | 3 |
| PLOD1 | XPR1 | 0.754697 | 7 | 0 | 7 |
| PLOD1 | LAPTM4B | 0.74825 | 11 | 0 | 11 |
For details and further investigation, click here
