| Full name: CCM2 scaffold protein | Alias Symbol: MGC4607|OSM | ||
| Type: protein-coding gene | Cytoband: 7p13 | ||
| Entrez ID: 83605 | HGNC ID: HGNC:21708 | Ensembl Gene: ENSG00000136280 | OMIM ID: 607929 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of CCM2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CCM2 | 83605 | 223164_at | 1.0783 | 0.0300 | |
| GSE26886 | CCM2 | 83605 | 223164_at | 1.3812 | 0.0000 | |
| GSE45670 | CCM2 | 83605 | 223164_at | 0.6267 | 0.0023 | |
| GSE53622 | CCM2 | 83605 | 1592 | 0.6893 | 0.0000 | |
| GSE53624 | CCM2 | 83605 | 1592 | 1.0535 | 0.0000 | |
| GSE63941 | CCM2 | 83605 | 223164_at | 0.0217 | 0.9625 | |
| GSE77861 | CCM2 | 83605 | 223164_at | 0.3115 | 0.0820 | |
| GSE97050 | CCM2 | 83605 | A_33_P3209476 | 0.6331 | 0.1372 | |
| SRP007169 | CCM2 | 83605 | RNAseq | 0.8412 | 0.0331 | |
| SRP008496 | CCM2 | 83605 | RNAseq | 0.8469 | 0.0021 | |
| SRP064894 | CCM2 | 83605 | RNAseq | 1.5956 | 0.0000 | |
| SRP133303 | CCM2 | 83605 | RNAseq | 1.0341 | 0.0000 | |
| SRP159526 | CCM2 | 83605 | RNAseq | 0.7002 | 0.0122 | |
| SRP193095 | CCM2 | 83605 | RNAseq | 0.7768 | 0.0000 | |
| SRP219564 | CCM2 | 83605 | RNAseq | 0.7104 | 0.0698 | |
| TCGA | CCM2 | 83605 | RNAseq | 0.1761 | 0.0078 |
Upregulated datasets: 5; Downregulated datasets: 0.
Survival by CCM2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of CCM2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CCM2 | 83605 | 13 | 0 | 17 | |
| GSE20123 | CCM2 | 83605 | 12 | 0 | 18 | |
| GSE43470 | CCM2 | 83605 | 4 | 0 | 39 | |
| GSE46452 | CCM2 | 83605 | 11 | 1 | 47 | |
| GSE47630 | CCM2 | 83605 | 8 | 1 | 31 | |
| GSE54993 | CCM2 | 83605 | 0 | 8 | 62 | |
| GSE54994 | CCM2 | 83605 | 16 | 3 | 34 | |
| GSE60625 | CCM2 | 83605 | 0 | 0 | 11 | |
| GSE74703 | CCM2 | 83605 | 4 | 0 | 32 | |
| GSE74704 | CCM2 | 83605 | 6 | 0 | 14 | |
| TCGA | CCM2 | 83605 | 50 | 7 | 39 |
Total number of gains: 124; Total number of losses: 20; Total Number of normals: 344.
Somatic mutations of CCM2:
Generating mutation plots.
Highly correlated genes for CCM2:
Showing top 20/1867 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CCM2 | SLC2A3 | 0.837104 | 3 | 0 | 3 |
| CCM2 | ORC2 | 0.825997 | 3 | 0 | 3 |
| CCM2 | LGALS8 | 0.825091 | 3 | 0 | 3 |
| CCM2 | PET117 | 0.822073 | 3 | 0 | 3 |
| CCM2 | GPR153 | 0.81719 | 5 | 0 | 5 |
| CCM2 | ROMO1 | 0.814629 | 3 | 0 | 3 |
| CCM2 | CIAO1 | 0.792904 | 3 | 0 | 3 |
| CCM2 | YLPM1 | 0.792047 | 3 | 0 | 3 |
| CCM2 | ADCY3 | 0.781275 | 4 | 0 | 4 |
| CCM2 | SLC39A3 | 0.776153 | 4 | 0 | 4 |
| CCM2 | AGRN | 0.770067 | 8 | 0 | 7 |
| CCM2 | SPIRE1 | 0.767558 | 3 | 0 | 3 |
| CCM2 | CCDC127 | 0.76709 | 3 | 0 | 3 |
| CCM2 | KLC1 | 0.766741 | 3 | 0 | 3 |
| CCM2 | RUNX1-IT1 | 0.766371 | 4 | 0 | 4 |
| CCM2 | IRF9 | 0.76624 | 4 | 0 | 4 |
| CCM2 | TMEM184B | 0.766011 | 7 | 0 | 7 |
| CCM2 | FZD6 | 0.764027 | 4 | 0 | 4 |
| CCM2 | EPPK1 | 0.761009 | 5 | 0 | 4 |
| CCM2 | ZNF707 | 0.760985 | 3 | 0 | 3 |
For details and further investigation, click here
