B3GALT6

 

Full name: beta-1,3-galactosyltransferase 6 Alias Symbol: beta3GalT6
Type: protein-coding gene Cytoband: 1p36.33
Entrez ID: 126792 HGNC ID: HGNC:17978 Ensembl Gene: ENSG00000176022 OMIM ID: 615291
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

Expression of B3GALT6:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 B3GALT6 126792 1553959_a_at 1.2061 0.0353
GSE26886 B3GALT6 126792 1553959_a_at 2.1980 0.0000
GSE45670 B3GALT6 126792 1553959_a_at 0.7545 0.0029
GSE53622 B3GALT6 126792 45449 0.7530 0.0000
GSE53624 B3GALT6 126792 45449 1.0402 0.0000
GSE63941 B3GALT6 126792 1553959_a_at -0.6331 0.3732
GSE77861 B3GALT6 126792 225733_at -0.0154 0.9395
GSE97050 B3GALT6 126792 A_33_P3407042 0.4585 0.1939
SRP007169 B3GALT6 126792 RNAseq 0.0127 0.9792
SRP008496 B3GALT6 126792 RNAseq 0.6275 0.1620
SRP064894 B3GALT6 126792 RNAseq 1.8054 0.0000
SRP133303 B3GALT6 126792 RNAseq 0.8247 0.0000
SRP159526 B3GALT6 126792 RNAseq 1.3057 0.0087
SRP193095 B3GALT6 126792 RNAseq 0.8646 0.0000
SRP219564 B3GALT6 126792 RNAseq 0.8698 0.0109
TCGA B3GALT6 126792 RNAseq 0.1950 0.0010

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by B3GALT6 expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of B3GALT6:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 B3GALT6 126792 3 7 20
GSE20123 B3GALT6 126792 3 6 21
GSE43470 B3GALT6 126792 3 5 35
GSE46452 B3GALT6 126792 7 1 51
GSE47630 B3GALT6 126792 8 4 28
GSE54993 B3GALT6 126792 2 2 66
GSE54994 B3GALT6 126792 15 2 36
GSE60625 B3GALT6 126792 0 0 11
GSE74703 B3GALT6 126792 3 3 30
GSE74704 B3GALT6 126792 3 0 17
TCGA B3GALT6 126792 14 20 62

Total number of gains: 61; Total number of losses: 50; Total Number of normals: 377.  

 

Somatic mutations of B3GALT6:

 

Generating mutation plots.

 

Highly correlated genes for B3GALT6:

 

Showing top 20/1610 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
B3GALT6DERL10.826065404
B3GALT6MTERF30.81559303
B3GALT6WDR810.813349303
B3GALT6KHSRP0.810373404
B3GALT6PLXNA10.805967606
B3GALT6LAPTM4B0.797733606
B3GALT6HNRNPUL10.794572303
B3GALT6COMMD70.792809303
B3GALT6FANCL0.790778303
B3GALT6POLR2K0.789663404
B3GALT6WDR540.788641505
B3GALT6DCAF130.788112505
B3GALT6DNMT10.787834606
B3GALT6AGRN0.784365606
B3GALT6ELF40.771856504
B3GALT6SLC25A320.770484606
B3GALT6SDF40.770314807
B3GALT6ORC30.76921404
B3GALT6TUBA1B0.768718303
B3GALT6U2SURP0.768092404

For details and further investigation, click here