| Full name: Rap guanine nucleotide exchange factor 6 | Alias Symbol: RA-GEF-2|PDZ-GEF2 | ||
| Type: protein-coding gene | Cytoband: 5q31.1 | ||
| Entrez ID: 51735 | HGNC ID: HGNC:20655 | Ensembl Gene: ENSG00000158987 | OMIM ID: 610499 |
| Drug and gene relationship at DGIdb | |||
RAPGEF6 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04015 | Rap1 signaling pathway |
Expression of RAPGEF6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RAPGEF6 | 51735 | 230078_at | -0.1518 | 0.7231 | |
| GSE20347 | RAPGEF6 | 51735 | 219112_at | 0.3426 | 0.0327 | |
| GSE23400 | RAPGEF6 | 51735 | 219112_at | 0.1861 | 0.0118 | |
| GSE26886 | RAPGEF6 | 51735 | 230078_at | 0.8836 | 0.0019 | |
| GSE29001 | RAPGEF6 | 51735 | 219112_at | 0.1638 | 0.5336 | |
| GSE38129 | RAPGEF6 | 51735 | 219112_at | 0.2756 | 0.2201 | |
| GSE45670 | RAPGEF6 | 51735 | 230078_at | -0.1587 | 0.2628 | |
| GSE53622 | RAPGEF6 | 51735 | 45810 | -0.2787 | 0.0559 | |
| GSE53624 | RAPGEF6 | 51735 | 45810 | -0.2744 | 0.0170 | |
| GSE63941 | RAPGEF6 | 51735 | 230078_at | -0.1117 | 0.7734 | |
| GSE77861 | RAPGEF6 | 51735 | 230078_at | -0.0985 | 0.7278 | |
| GSE97050 | RAPGEF6 | 51735 | A_33_P3243519 | 0.4253 | 0.2469 | |
| SRP007169 | RAPGEF6 | 51735 | RNAseq | 0.3920 | 0.3755 | |
| SRP008496 | RAPGEF6 | 51735 | RNAseq | 0.1477 | 0.6005 | |
| SRP064894 | RAPGEF6 | 51735 | RNAseq | -0.0464 | 0.8471 | |
| SRP133303 | RAPGEF6 | 51735 | RNAseq | 0.1218 | 0.3453 | |
| SRP159526 | RAPGEF6 | 51735 | RNAseq | -0.3945 | 0.3707 | |
| SRP193095 | RAPGEF6 | 51735 | RNAseq | -0.0576 | 0.6337 | |
| SRP219564 | RAPGEF6 | 51735 | RNAseq | -0.3854 | 0.3352 | |
| TCGA | RAPGEF6 | 51735 | RNAseq | -0.0414 | 0.5475 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by RAPGEF6 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RAPGEF6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RAPGEF6 | 51735 | 1 | 12 | 17 | |
| GSE20123 | RAPGEF6 | 51735 | 1 | 12 | 17 | |
| GSE43470 | RAPGEF6 | 51735 | 2 | 9 | 32 | |
| GSE46452 | RAPGEF6 | 51735 | 0 | 27 | 32 | |
| GSE47630 | RAPGEF6 | 51735 | 0 | 21 | 19 | |
| GSE54993 | RAPGEF6 | 51735 | 9 | 1 | 60 | |
| GSE54994 | RAPGEF6 | 51735 | 1 | 15 | 37 | |
| GSE60625 | RAPGEF6 | 51735 | 0 | 0 | 11 | |
| GSE74703 | RAPGEF6 | 51735 | 2 | 6 | 28 | |
| GSE74704 | RAPGEF6 | 51735 | 1 | 6 | 13 | |
| TCGA | RAPGEF6 | 51735 | 4 | 40 | 52 |
Total number of gains: 21; Total number of losses: 149; Total Number of normals: 318.
Somatic mutations of RAPGEF6:
Generating mutation plots.
Highly correlated genes for RAPGEF6:
Showing top 20/257 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RAPGEF6 | CDC40 | 0.794898 | 3 | 0 | 3 |
| RAPGEF6 | KCTD18 | 0.753001 | 3 | 0 | 3 |
| RAPGEF6 | HEXB | 0.744099 | 5 | 0 | 5 |
| RAPGEF6 | SSH1 | 0.728616 | 3 | 0 | 3 |
| RAPGEF6 | VASH1 | 0.725815 | 3 | 0 | 3 |
| RAPGEF6 | UBR1 | 0.724236 | 3 | 0 | 3 |
| RAPGEF6 | RBBP6 | 0.723321 | 4 | 0 | 4 |
| RAPGEF6 | C16orf87 | 0.722419 | 3 | 0 | 3 |
| RAPGEF6 | C17orf75 | 0.715609 | 3 | 0 | 3 |
| RAPGEF6 | AHR | 0.712702 | 3 | 0 | 3 |
| RAPGEF6 | KLF7 | 0.712182 | 4 | 0 | 4 |
| RAPGEF6 | RNF24 | 0.706868 | 3 | 0 | 3 |
| RAPGEF6 | SLC30A4 | 0.706565 | 3 | 0 | 3 |
| RAPGEF6 | ATP13A3 | 0.703044 | 3 | 0 | 3 |
| RAPGEF6 | RNF13 | 0.70243 | 3 | 0 | 3 |
| RAPGEF6 | VEGFC | 0.702181 | 3 | 0 | 3 |
| RAPGEF6 | ISCA1 | 0.697195 | 3 | 0 | 3 |
| RAPGEF6 | ZNF547 | 0.697131 | 3 | 0 | 3 |
| RAPGEF6 | SPIRE1 | 0.692697 | 3 | 0 | 3 |
| RAPGEF6 | TMEM106B | 0.691312 | 4 | 0 | 3 |
For details and further investigation, click here
