| Full name: hypoxia inducible factor 3 subunit alpha | Alias Symbol: IPAS|MOP7|PASD7|bHLHe17 | ||
| Type: protein-coding gene | Cytoband: 19q13.32 | ||
| Entrez ID: 64344 | HGNC ID: HGNC:15825 | Ensembl Gene: ENSG00000124440 | OMIM ID: 609976 |
| Drug and gene relationship at DGIdb | |||
Expression of HIF3A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HIF3A | 64344 | 1556069_s_at | -0.8178 | 0.3970 | |
| GSE20347 | HIF3A | 64344 | 219319_at | -0.1007 | 0.1961 | |
| GSE23400 | HIF3A | 64344 | 222124_at | -0.0930 | 0.1730 | |
| GSE26886 | HIF3A | 64344 | 233517_s_at | -0.5501 | 0.0004 | |
| GSE29001 | HIF3A | 64344 | 219319_at | -0.1874 | 0.4257 | |
| GSE38129 | HIF3A | 64344 | 219319_at | -0.3495 | 0.0014 | |
| GSE45670 | HIF3A | 64344 | 219319_at | -0.3031 | 0.0003 | |
| GSE53622 | HIF3A | 64344 | 118875 | -1.1915 | 0.0000 | |
| GSE53624 | HIF3A | 64344 | 118875 | -0.7310 | 0.0000 | |
| GSE63941 | HIF3A | 64344 | 233517_s_at | 0.2362 | 0.1804 | |
| GSE77861 | HIF3A | 64344 | 219319_at | -0.0699 | 0.6052 | |
| GSE97050 | HIF3A | 64344 | A_33_P3338152 | -0.1062 | 0.7876 | |
| SRP007169 | HIF3A | 64344 | RNAseq | 2.1033 | 0.0120 | |
| SRP064894 | HIF3A | 64344 | RNAseq | -1.3114 | 0.0048 | |
| SRP133303 | HIF3A | 64344 | RNAseq | -1.2096 | 0.0026 | |
| SRP159526 | HIF3A | 64344 | RNAseq | -1.0707 | 0.1436 | |
| SRP193095 | HIF3A | 64344 | RNAseq | 0.2921 | 0.1396 | |
| SRP219564 | HIF3A | 64344 | RNAseq | -1.3726 | 0.1480 | |
| TCGA | HIF3A | 64344 | RNAseq | -1.7448 | 0.0000 |
Upregulated datasets: 1; Downregulated datasets: 4.
Survival by HIF3A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HIF3A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HIF3A | 64344 | 4 | 5 | 21 | |
| GSE20123 | HIF3A | 64344 | 4 | 4 | 22 | |
| GSE43470 | HIF3A | 64344 | 3 | 11 | 29 | |
| GSE46452 | HIF3A | 64344 | 45 | 1 | 13 | |
| GSE47630 | HIF3A | 64344 | 8 | 7 | 25 | |
| GSE54993 | HIF3A | 64344 | 17 | 4 | 49 | |
| GSE54994 | HIF3A | 64344 | 5 | 13 | 35 | |
| GSE60625 | HIF3A | 64344 | 9 | 0 | 2 | |
| GSE74703 | HIF3A | 64344 | 3 | 7 | 26 | |
| GSE74704 | HIF3A | 64344 | 4 | 2 | 14 | |
| TCGA | HIF3A | 64344 | 15 | 15 | 66 |
Total number of gains: 117; Total number of losses: 69; Total Number of normals: 302.
Somatic mutations of HIF3A:
Generating mutation plots.
Highly correlated genes for HIF3A:
Showing top 20/595 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HIF3A | TRIM31 | 0.766319 | 3 | 0 | 3 |
| HIF3A | GKAP1 | 0.717558 | 4 | 0 | 3 |
| HIF3A | GRIPAP1 | 0.714539 | 3 | 0 | 3 |
| HIF3A | CNTD2 | 0.710837 | 4 | 0 | 4 |
| HIF3A | PNCK | 0.706254 | 3 | 0 | 3 |
| HIF3A | GPR78 | 0.699209 | 3 | 0 | 3 |
| HIF3A | LTBP4 | 0.698832 | 5 | 0 | 4 |
| HIF3A | DLK1 | 0.6964 | 3 | 0 | 3 |
| HIF3A | CHD5 | 0.691641 | 6 | 0 | 4 |
| HIF3A | TPH2 | 0.682972 | 3 | 0 | 3 |
| HIF3A | SNAP91 | 0.682324 | 6 | 0 | 5 |
| HIF3A | ZDHHC15 | 0.677722 | 4 | 0 | 4 |
| HIF3A | CATSPER3 | 0.670878 | 3 | 0 | 3 |
| HIF3A | ACACB | 0.670602 | 7 | 0 | 7 |
| HIF3A | IGSF9B | 0.670298 | 8 | 0 | 6 |
| HIF3A | TKTL1 | 0.666332 | 3 | 0 | 3 |
| HIF3A | SMCP | 0.663098 | 3 | 0 | 3 |
| HIF3A | C20orf141 | 0.662779 | 3 | 0 | 3 |
| HIF3A | TRIM17 | 0.662493 | 3 | 0 | 3 |
| HIF3A | SLC25A4 | 0.662168 | 5 | 0 | 4 |
For details and further investigation, click here
