| Full name: G protein-coupled receptor 78 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 4p16.1 | ||
| Entrez ID: 27201 | HGNC ID: HGNC:4528 | Ensembl Gene: ENSG00000155269 | OMIM ID: 606921 |
| Drug and gene relationship at DGIdb | |||
Expression of GPR78:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GPR78 | 27201 | 1553063_at | -0.1860 | 0.4315 | |
| GSE26886 | GPR78 | 27201 | 1553063_at | 0.0948 | 0.3946 | |
| GSE45670 | GPR78 | 27201 | 1553063_at | 0.1748 | 0.0955 | |
| GSE63941 | GPR78 | 27201 | 1553063_at | 0.1665 | 0.3809 | |
| GSE77861 | GPR78 | 27201 | 1553063_at | -0.1899 | 0.1019 | |
| GSE97050 | GPR78 | 27201 | A_33_P3222942 | -0.1187 | 0.5507 | |
| SRP064894 | GPR78 | 27201 | RNAseq | -3.1534 | 0.0000 | |
| SRP133303 | GPR78 | 27201 | RNAseq | -2.0227 | 0.0000 | |
| SRP159526 | GPR78 | 27201 | RNAseq | -4.4161 | 0.0000 | |
| SRP193095 | GPR78 | 27201 | RNAseq | -1.6858 | 0.0000 | |
| SRP219564 | GPR78 | 27201 | RNAseq | -2.4912 | 0.0156 | |
| TCGA | GPR78 | 27201 | RNAseq | 0.0744 | 0.9403 |
Upregulated datasets: 0; Downregulated datasets: 5.
Survival by GPR78 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of GPR78:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPR78 | 27201 | 0 | 18 | 12 | |
| GSE20123 | GPR78 | 27201 | 0 | 18 | 12 | |
| GSE43470 | GPR78 | 27201 | 0 | 17 | 26 | |
| GSE46452 | GPR78 | 27201 | 1 | 36 | 22 | |
| GSE47630 | GPR78 | 27201 | 1 | 19 | 20 | |
| GSE54993 | GPR78 | 27201 | 10 | 0 | 60 | |
| GSE54994 | GPR78 | 27201 | 3 | 12 | 38 | |
| GSE60625 | GPR78 | 27201 | 0 | 0 | 11 | |
| GSE74703 | GPR78 | 27201 | 0 | 13 | 23 | |
| GSE74704 | GPR78 | 27201 | 0 | 10 | 10 | |
| TCGA | GPR78 | 27201 | 9 | 47 | 40 |
Total number of gains: 24; Total number of losses: 190; Total Number of normals: 274.
Somatic mutations of GPR78:
Generating mutation plots.
Highly correlated genes for GPR78:
Showing top 20/230 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPR78 | NT5C1A | 0.870658 | 3 | 0 | 3 |
| GPR78 | MAPKAPK3 | 0.801303 | 3 | 0 | 3 |
| GPR78 | ETHE1 | 0.784559 | 3 | 0 | 3 |
| GPR78 | BCKDHA | 0.77753 | 3 | 0 | 3 |
| GPR78 | SEC13 | 0.770034 | 3 | 0 | 3 |
| GPR78 | MOS | 0.769981 | 3 | 0 | 3 |
| GPR78 | PTK6 | 0.760862 | 3 | 0 | 3 |
| GPR78 | SLC6A18 | 0.760487 | 3 | 0 | 3 |
| GPR78 | B3GNT8 | 0.759115 | 3 | 0 | 3 |
| GPR78 | EPS8L2 | 0.755655 | 3 | 0 | 3 |
| GPR78 | PRRG3 | 0.752312 | 3 | 0 | 3 |
| GPR78 | CCDC42 | 0.75211 | 3 | 0 | 3 |
| GPR78 | CACNG8 | 0.747594 | 3 | 0 | 3 |
| GPR78 | FAM171A2 | 0.747135 | 3 | 0 | 3 |
| GPR78 | IL17RC | 0.737947 | 3 | 0 | 3 |
| GPR78 | CXCR3 | 0.736465 | 3 | 0 | 3 |
| GPR78 | CYP2E1 | 0.735852 | 3 | 0 | 3 |
| GPR78 | TMEM125 | 0.733032 | 3 | 0 | 3 |
| GPR78 | IGFL1 | 0.728707 | 3 | 0 | 3 |
| GPR78 | MFSD1 | 0.726939 | 3 | 0 | 3 |
For details and further investigation, click here
