| Full name: solute carrier family 25 member 4 | Alias Symbol: T1 | ||
| Type: protein-coding gene | Cytoband: 4q35.1 | ||
| Entrez ID: 291 | HGNC ID: HGNC:10990 | Ensembl Gene: ENSG00000151729 | OMIM ID: 103220 |
| Drug and gene relationship at DGIdb | |||
SLC25A4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04020 | Calcium signaling pathway | |
| hsa04022 | cGMP-PKG signaling pathway | |
| hsa05012 | Parkinson's disease |
Expression of SLC25A4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SLC25A4 | 291 | 202825_at | -0.9574 | 0.3448 | |
| GSE20347 | SLC25A4 | 291 | 202825_at | -0.1087 | 0.5605 | |
| GSE23400 | SLC25A4 | 291 | 202825_at | -0.3940 | 0.0027 | |
| GSE26886 | SLC25A4 | 291 | 202825_at | -0.2567 | 0.2389 | |
| GSE29001 | SLC25A4 | 291 | 202825_at | -0.3144 | 0.2007 | |
| GSE38129 | SLC25A4 | 291 | 202825_at | -0.5093 | 0.0412 | |
| GSE45670 | SLC25A4 | 291 | 202825_at | -0.8382 | 0.0000 | |
| GSE53622 | SLC25A4 | 291 | 40208 | -0.6478 | 0.0000 | |
| GSE53624 | SLC25A4 | 291 | 40208 | -0.3508 | 0.0000 | |
| GSE63941 | SLC25A4 | 291 | 202825_at | 0.2817 | 0.7150 | |
| GSE77861 | SLC25A4 | 291 | 202825_at | 0.3366 | 0.1920 | |
| GSE97050 | SLC25A4 | 291 | A_24_P206047 | -0.9209 | 0.1879 | |
| SRP007169 | SLC25A4 | 291 | RNAseq | 1.2294 | 0.0801 | |
| SRP064894 | SLC25A4 | 291 | RNAseq | -0.6501 | 0.0436 | |
| SRP133303 | SLC25A4 | 291 | RNAseq | -0.1720 | 0.6192 | |
| SRP159526 | SLC25A4 | 291 | RNAseq | -0.0578 | 0.8198 | |
| SRP193095 | SLC25A4 | 291 | RNAseq | -0.3582 | 0.0069 | |
| SRP219564 | SLC25A4 | 291 | RNAseq | -0.8318 | 0.4061 | |
| TCGA | SLC25A4 | 291 | RNAseq | -0.7258 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by SLC25A4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SLC25A4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SLC25A4 | 291 | 3 | 11 | 16 | |
| GSE20123 | SLC25A4 | 291 | 3 | 11 | 16 | |
| GSE43470 | SLC25A4 | 291 | 1 | 13 | 29 | |
| GSE46452 | SLC25A4 | 291 | 1 | 36 | 22 | |
| GSE47630 | SLC25A4 | 291 | 0 | 22 | 18 | |
| GSE54993 | SLC25A4 | 291 | 10 | 0 | 60 | |
| GSE54994 | SLC25A4 | 291 | 2 | 12 | 39 | |
| GSE60625 | SLC25A4 | 291 | 0 | 0 | 11 | |
| GSE74703 | SLC25A4 | 291 | 1 | 10 | 25 | |
| GSE74704 | SLC25A4 | 291 | 1 | 5 | 14 | |
| TCGA | SLC25A4 | 291 | 11 | 32 | 53 |
Total number of gains: 33; Total number of losses: 152; Total Number of normals: 303.
Somatic mutations of SLC25A4:
Generating mutation plots.
Highly correlated genes for SLC25A4:
Showing top 20/438 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SLC25A4 | GKAP1 | 0.797272 | 4 | 0 | 3 |
| SLC25A4 | ITGB1BP2 | 0.79673 | 6 | 0 | 6 |
| SLC25A4 | MITF | 0.78254 | 6 | 0 | 6 |
| SLC25A4 | RBPMS2 | 0.75872 | 4 | 0 | 4 |
| SLC25A4 | FNDC5 | 0.750931 | 3 | 0 | 3 |
| SLC25A4 | C3orf70 | 0.744195 | 4 | 0 | 4 |
| SLC25A4 | NPY | 0.74353 | 6 | 0 | 6 |
| SLC25A4 | ANO5 | 0.743183 | 4 | 0 | 4 |
| SLC25A4 | FBXO30 | 0.742207 | 4 | 0 | 4 |
| SLC25A4 | BHMT2 | 0.737572 | 7 | 0 | 7 |
| SLC25A4 | KBTBD12 | 0.733292 | 5 | 0 | 5 |
| SLC25A4 | SPOP | 0.724062 | 7 | 0 | 6 |
| SLC25A4 | LINC00472 | 0.718844 | 4 | 0 | 4 |
| SLC25A4 | CHRDL1 | 0.717301 | 7 | 0 | 7 |
| SLC25A4 | CBX7 | 0.706691 | 9 | 0 | 7 |
| SLC25A4 | TCEAL2 | 0.704923 | 8 | 0 | 7 |
| SLC25A4 | INMT | 0.703858 | 4 | 0 | 3 |
| SLC25A4 | MOAP1 | 0.702579 | 8 | 0 | 6 |
| SLC25A4 | RRAS | 0.699076 | 4 | 0 | 4 |
| SLC25A4 | MYOM1 | 0.699028 | 10 | 0 | 9 |
For details and further investigation, click here
