| Full name: latent transforming growth factor beta binding protein 4 | Alias Symbol: LTBP-4|LTBP-4L|FLJ46318|FLJ90018 | ||
| Type: protein-coding gene | Cytoband: 19q13.1-q13.2 | ||
| Entrez ID: 8425 | HGNC ID: HGNC:6717 | Ensembl Gene: ENSG00000090006 | OMIM ID: 604710 |
| Drug and gene relationship at DGIdb | |||
Expression of LTBP4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LTBP4 | 8425 | 204442_x_at | -0.7996 | 0.1922 | |
| GSE20347 | LTBP4 | 8425 | 204442_x_at | -0.0944 | 0.7498 | |
| GSE23400 | LTBP4 | 8425 | 213176_s_at | -0.1884 | 0.0502 | |
| GSE26886 | LTBP4 | 8425 | 204442_x_at | 0.3117 | 0.2172 | |
| GSE29001 | LTBP4 | 8425 | 213176_s_at | -0.0715 | 0.6236 | |
| GSE38129 | LTBP4 | 8425 | 204442_x_at | -0.7238 | 0.0178 | |
| GSE45670 | LTBP4 | 8425 | 204442_x_at | -0.7681 | 0.0003 | |
| GSE53622 | LTBP4 | 8425 | 67765 | -0.9265 | 0.0000 | |
| GSE53624 | LTBP4 | 8425 | 15274 | -0.7324 | 0.0000 | |
| GSE63941 | LTBP4 | 8425 | 213176_s_at | 0.1190 | 0.7223 | |
| GSE77861 | LTBP4 | 8425 | 204442_x_at | 0.2916 | 0.3206 | |
| GSE97050 | LTBP4 | 8425 | A_33_P3348091 | -0.9703 | 0.1711 | |
| SRP007169 | LTBP4 | 8425 | RNAseq | 0.1517 | 0.7350 | |
| SRP008496 | LTBP4 | 8425 | RNAseq | -0.1564 | 0.6087 | |
| SRP064894 | LTBP4 | 8425 | RNAseq | -0.9105 | 0.0002 | |
| SRP133303 | LTBP4 | 8425 | RNAseq | -1.4015 | 0.0000 | |
| SRP159526 | LTBP4 | 8425 | RNAseq | -0.6410 | 0.0089 | |
| SRP193095 | LTBP4 | 8425 | RNAseq | -0.0025 | 0.9887 | |
| SRP219564 | LTBP4 | 8425 | RNAseq | -0.5748 | 0.2196 | |
| TCGA | LTBP4 | 8425 | RNAseq | -0.3770 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by LTBP4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LTBP4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LTBP4 | 8425 | 6 | 5 | 19 | |
| GSE20123 | LTBP4 | 8425 | 6 | 4 | 20 | |
| GSE43470 | LTBP4 | 8425 | 3 | 9 | 31 | |
| GSE46452 | LTBP4 | 8425 | 48 | 1 | 10 | |
| GSE47630 | LTBP4 | 8425 | 9 | 5 | 26 | |
| GSE54993 | LTBP4 | 8425 | 17 | 4 | 49 | |
| GSE54994 | LTBP4 | 8425 | 8 | 9 | 36 | |
| GSE60625 | LTBP4 | 8425 | 9 | 0 | 2 | |
| GSE74703 | LTBP4 | 8425 | 3 | 6 | 27 | |
| GSE74704 | LTBP4 | 8425 | 6 | 2 | 12 | |
| TCGA | LTBP4 | 8425 | 14 | 16 | 66 |
Total number of gains: 129; Total number of losses: 61; Total Number of normals: 298.
Somatic mutations of LTBP4:
Generating mutation plots.
Highly correlated genes for LTBP4:
Showing top 20/742 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LTBP4 | CYP21A2 | 0.75025 | 3 | 0 | 3 |
| LTBP4 | TAF1 | 0.721715 | 3 | 0 | 3 |
| LTBP4 | CLEC3B | 0.719127 | 3 | 0 | 3 |
| LTBP4 | SORCS1 | 0.715829 | 4 | 0 | 4 |
| LTBP4 | RGS7BP | 0.708439 | 5 | 0 | 5 |
| LTBP4 | HIF3A | 0.698832 | 5 | 0 | 4 |
| LTBP4 | UBXN10 | 0.697418 | 3 | 0 | 3 |
| LTBP4 | ATP1B2 | 0.697327 | 6 | 0 | 6 |
| LTBP4 | ABCA6 | 0.687603 | 9 | 0 | 8 |
| LTBP4 | C1QTNF2 | 0.682924 | 4 | 0 | 4 |
| LTBP4 | ANGPTL1 | 0.682872 | 5 | 0 | 5 |
| LTBP4 | F10 | 0.681338 | 7 | 0 | 6 |
| LTBP4 | ARHGAP6 | 0.67921 | 7 | 0 | 6 |
| LTBP4 | LIMS2 | 0.678604 | 9 | 0 | 8 |
| LTBP4 | C1QTNF7 | 0.675166 | 6 | 0 | 5 |
| LTBP4 | NEGR1 | 0.67257 | 6 | 0 | 5 |
| LTBP4 | GSN | 0.67009 | 7 | 0 | 5 |
| LTBP4 | CHCHD10 | 0.66802 | 3 | 0 | 3 |
| LTBP4 | PI16 | 0.667498 | 6 | 0 | 6 |
| LTBP4 | NLGN1 | 0.666822 | 7 | 0 | 6 |
For details and further investigation, click here
