| Full name: homeodomain interacting protein kinase 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 7q34 | ||
| Entrez ID: 28996 | HGNC ID: HGNC:14402 | Ensembl Gene: ENSG00000064393 | OMIM ID: 606868 |
| Drug and gene relationship at DGIdb | |||
Expression of HIPK2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HIPK2 | 28996 | 225368_at | -0.0110 | 0.9894 | |
| GSE20347 | HIPK2 | 28996 | 219028_at | -0.6382 | 0.0000 | |
| GSE23400 | HIPK2 | 28996 | 213763_at | -0.1397 | 0.0001 | |
| GSE26886 | HIPK2 | 28996 | 225368_at | -2.1973 | 0.0000 | |
| GSE29001 | HIPK2 | 28996 | 213763_at | -0.6239 | 0.0242 | |
| GSE38129 | HIPK2 | 28996 | 219028_at | -0.5033 | 0.0014 | |
| GSE45670 | HIPK2 | 28996 | 225368_at | -0.5611 | 0.0015 | |
| GSE53622 | HIPK2 | 28996 | 16764 | -0.9426 | 0.0000 | |
| GSE53624 | HIPK2 | 28996 | 16764 | -0.8498 | 0.0000 | |
| GSE63941 | HIPK2 | 28996 | 225368_at | -2.5187 | 0.0003 | |
| GSE77861 | HIPK2 | 28996 | 225368_at | -1.0890 | 0.0138 | |
| GSE97050 | HIPK2 | 28996 | A_33_P3223121 | -0.1228 | 0.6672 | |
| SRP007169 | HIPK2 | 28996 | RNAseq | -0.5888 | 0.1657 | |
| SRP008496 | HIPK2 | 28996 | RNAseq | -0.4701 | 0.0808 | |
| SRP064894 | HIPK2 | 28996 | RNAseq | -0.5680 | 0.0337 | |
| SRP133303 | HIPK2 | 28996 | RNAseq | -0.6773 | 0.0001 | |
| SRP159526 | HIPK2 | 28996 | RNAseq | -0.5061 | 0.0727 | |
| SRP193095 | HIPK2 | 28996 | RNAseq | -0.6739 | 0.0000 | |
| SRP219564 | HIPK2 | 28996 | RNAseq | -1.0992 | 0.0217 | |
| TCGA | HIPK2 | 28996 | RNAseq | -0.3615 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 4.
Survival by HIPK2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HIPK2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HIPK2 | 28996 | 5 | 2 | 23 | |
| GSE20123 | HIPK2 | 28996 | 5 | 2 | 23 | |
| GSE43470 | HIPK2 | 28996 | 2 | 3 | 38 | |
| GSE46452 | HIPK2 | 28996 | 7 | 2 | 50 | |
| GSE47630 | HIPK2 | 28996 | 7 | 4 | 29 | |
| GSE54993 | HIPK2 | 28996 | 3 | 5 | 62 | |
| GSE54994 | HIPK2 | 28996 | 5 | 8 | 40 | |
| GSE60625 | HIPK2 | 28996 | 0 | 0 | 11 | |
| GSE74703 | HIPK2 | 28996 | 2 | 3 | 31 | |
| GSE74704 | HIPK2 | 28996 | 1 | 2 | 17 | |
| TCGA | HIPK2 | 28996 | 28 | 23 | 45 |
Total number of gains: 65; Total number of losses: 54; Total Number of normals: 369.
Somatic mutations of HIPK2:
Generating mutation plots.
Highly correlated genes for HIPK2:
Showing top 20/1128 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HIPK2 | SNORA68 | 0.795061 | 3 | 0 | 3 |
| HIPK2 | SMDT1 | 0.750228 | 3 | 0 | 3 |
| HIPK2 | VSIG10L | 0.742591 | 5 | 0 | 5 |
| HIPK2 | TEKT5 | 0.720381 | 3 | 0 | 3 |
| HIPK2 | PCBP1-AS1 | 0.720248 | 3 | 0 | 3 |
| HIPK2 | ZNRF1 | 0.719133 | 5 | 0 | 5 |
| HIPK2 | RBM20 | 0.71666 | 4 | 0 | 4 |
| HIPK2 | TMEM234 | 0.71427 | 4 | 0 | 4 |
| HIPK2 | C5orf66-AS1 | 0.709653 | 6 | 0 | 6 |
| HIPK2 | ZFAND2B | 0.70832 | 7 | 0 | 6 |
| HIPK2 | ZNF585B | 0.706383 | 4 | 0 | 4 |
| HIPK2 | PPDPF | 0.706246 | 7 | 0 | 7 |
| HIPK2 | KALRN | 0.701441 | 6 | 0 | 6 |
| HIPK2 | P4HB | 0.701408 | 6 | 0 | 6 |
| HIPK2 | ADIPOR1 | 0.699931 | 7 | 0 | 7 |
| HIPK2 | CYSRT1 | 0.698992 | 5 | 0 | 5 |
| HIPK2 | CTTNBP2 | 0.696217 | 6 | 0 | 6 |
| HIPK2 | SAMD5 | 0.692086 | 6 | 0 | 6 |
| HIPK2 | WDR7 | 0.691919 | 3 | 0 | 3 |
| HIPK2 | PDLIM2 | 0.690246 | 7 | 0 | 6 |
For details and further investigation, click here
