| Full name: PDZ and LIM domain 2 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 8p21.3 | ||
| Entrez ID: 64236 | HGNC ID: HGNC:13992 | Ensembl Gene: ENSG00000120913 | OMIM ID: 609722 |
| Drug and gene relationship at DGIdb | |||
Expression of PDLIM2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | PDLIM2 | 64236 | 219165_at | -1.3892 | 0.0821 | |
| GSE20347 | PDLIM2 | 64236 | 219165_at | -1.9603 | 0.0000 | |
| GSE23400 | PDLIM2 | 64236 | 219165_at | -1.6540 | 0.0000 | |
| GSE26886 | PDLIM2 | 64236 | 219165_at | -2.2456 | 0.0000 | |
| GSE29001 | PDLIM2 | 64236 | 219165_at | -1.7616 | 0.0009 | |
| GSE38129 | PDLIM2 | 64236 | 219165_at | -1.5315 | 0.0000 | |
| GSE45670 | PDLIM2 | 64236 | 219165_at | -0.9612 | 0.0003 | |
| GSE53622 | PDLIM2 | 64236 | 84467 | 0.0860 | 0.4547 | |
| GSE53624 | PDLIM2 | 64236 | 84467 | 0.2756 | 0.1692 | |
| GSE63941 | PDLIM2 | 64236 | 219165_at | -3.9698 | 0.0002 | |
| GSE77861 | PDLIM2 | 64236 | 219165_at | -1.4581 | 0.0021 | |
| GSE97050 | PDLIM2 | 64236 | A_33_P3311371 | -0.5182 | 0.3058 | |
| SRP007169 | PDLIM2 | 64236 | RNAseq | -3.4742 | 0.0000 | |
| SRP008496 | PDLIM2 | 64236 | RNAseq | -3.2239 | 0.0000 | |
| SRP064894 | PDLIM2 | 64236 | RNAseq | -1.6960 | 0.0000 | |
| SRP133303 | PDLIM2 | 64236 | RNAseq | -1.8904 | 0.0000 | |
| SRP159526 | PDLIM2 | 64236 | RNAseq | -2.3826 | 0.0000 | |
| SRP193095 | PDLIM2 | 64236 | RNAseq | -1.6179 | 0.0000 | |
| SRP219564 | PDLIM2 | 64236 | RNAseq | -1.9987 | 0.0000 | |
| TCGA | PDLIM2 | 64236 | RNAseq | 0.1087 | 0.3344 |
Upregulated datasets: 0; Downregulated datasets: 14.
Survival by PDLIM2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of PDLIM2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | PDLIM2 | 64236 | 4 | 10 | 16 | |
| GSE20123 | PDLIM2 | 64236 | 4 | 10 | 16 | |
| GSE43470 | PDLIM2 | 64236 | 4 | 9 | 30 | |
| GSE46452 | PDLIM2 | 64236 | 13 | 13 | 33 | |
| GSE47630 | PDLIM2 | 64236 | 10 | 8 | 22 | |
| GSE54993 | PDLIM2 | 64236 | 2 | 14 | 54 | |
| GSE54994 | PDLIM2 | 64236 | 9 | 17 | 27 | |
| GSE60625 | PDLIM2 | 64236 | 3 | 0 | 8 | |
| GSE74703 | PDLIM2 | 64236 | 4 | 7 | 25 | |
| GSE74704 | PDLIM2 | 64236 | 3 | 7 | 10 | |
| TCGA | PDLIM2 | 64236 | 14 | 43 | 39 |
Total number of gains: 70; Total number of losses: 138; Total Number of normals: 280.
Somatic mutations of PDLIM2:
Generating mutation plots.
Highly correlated genes for PDLIM2:
Showing top 20/1259 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| PDLIM2 | CYSRT1 | 0.856796 | 4 | 0 | 4 |
| PDLIM2 | IL18 | 0.837483 | 8 | 0 | 8 |
| PDLIM2 | KRT78 | 0.82527 | 4 | 0 | 4 |
| PDLIM2 | GDPD3 | 0.823072 | 8 | 0 | 8 |
| PDLIM2 | CLIC3 | 0.823053 | 8 | 0 | 8 |
| PDLIM2 | TOM1 | 0.820026 | 9 | 0 | 9 |
| PDLIM2 | SH3GL1 | 0.819707 | 9 | 0 | 9 |
| PDLIM2 | MXD1 | 0.818681 | 8 | 0 | 8 |
| PDLIM2 | S100A16 | 0.818133 | 4 | 0 | 4 |
| PDLIM2 | DHRS1 | 0.815783 | 8 | 0 | 8 |
| PDLIM2 | LACTB | 0.815678 | 3 | 0 | 3 |
| PDLIM2 | CNN3 | 0.814735 | 7 | 0 | 7 |
| PDLIM2 | VASN | 0.813113 | 6 | 0 | 6 |
| PDLIM2 | PIM1 | 0.809502 | 9 | 0 | 9 |
| PDLIM2 | VAT1 | 0.805359 | 10 | 0 | 10 |
| PDLIM2 | FAM3D | 0.804612 | 4 | 0 | 4 |
| PDLIM2 | ULK3 | 0.804022 | 5 | 0 | 5 |
| PDLIM2 | GYS2 | 0.803774 | 8 | 0 | 8 |
| PDLIM2 | MGLL | 0.801689 | 10 | 0 | 10 |
| PDLIM2 | ECM1 | 0.800678 | 9 | 0 | 9 |
For details and further investigation, click here
