| Full name: prolyl 4-hydroxylase subunit beta | Alias Symbol: PDIA1|PROHB|DSI|GIT|PDI|PO4HB|P4Hbeta | ||
| Type: protein-coding gene | Cytoband: 17q25.3 | ||
| Entrez ID: 5034 | HGNC ID: HGNC:8548 | Ensembl Gene: ENSG00000185624 | OMIM ID: 176790 |
| Drug and gene relationship at DGIdb | |||
Expression of P4HB:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | P4HB | 5034 | 200654_at | 0.2073 | 0.6287 | |
| GSE20347 | P4HB | 5034 | 200654_at | -0.4856 | 0.0000 | |
| GSE23400 | P4HB | 5034 | 200654_at | -0.2363 | 0.0002 | |
| GSE26886 | P4HB | 5034 | 200654_at | -0.8259 | 0.0000 | |
| GSE29001 | P4HB | 5034 | 200654_at | -0.4585 | 0.2053 | |
| GSE38129 | P4HB | 5034 | 200654_at | -0.1005 | 0.4811 | |
| GSE45670 | P4HB | 5034 | 200654_at | 0.0993 | 0.4405 | |
| GSE63941 | P4HB | 5034 | 200654_at | -0.7030 | 0.0796 | |
| GSE77861 | P4HB | 5034 | 200654_at | -0.2558 | 0.1984 | |
| GSE97050 | P4HB | 5034 | A_33_P3252043 | 0.3477 | 0.4327 | |
| SRP007169 | P4HB | 5034 | RNAseq | -1.7677 | 0.0000 | |
| SRP008496 | P4HB | 5034 | RNAseq | -1.3738 | 0.0000 | |
| SRP064894 | P4HB | 5034 | RNAseq | -0.1623 | 0.4327 | |
| SRP133303 | P4HB | 5034 | RNAseq | -0.0729 | 0.7632 | |
| SRP159526 | P4HB | 5034 | RNAseq | -0.3755 | 0.1628 | |
| SRP193095 | P4HB | 5034 | RNAseq | -0.8048 | 0.0000 | |
| SRP219564 | P4HB | 5034 | RNAseq | -0.2461 | 0.6160 | |
| TCGA | P4HB | 5034 | RNAseq | -0.0646 | 0.0867 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by P4HB expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of P4HB:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | P4HB | 5034 | 4 | 4 | 22 | |
| GSE20123 | P4HB | 5034 | 4 | 4 | 22 | |
| GSE43470 | P4HB | 5034 | 3 | 5 | 35 | |
| GSE46452 | P4HB | 5034 | 34 | 0 | 25 | |
| GSE47630 | P4HB | 5034 | 9 | 2 | 29 | |
| GSE54993 | P4HB | 5034 | 2 | 5 | 63 | |
| GSE54994 | P4HB | 5034 | 10 | 6 | 37 | |
| GSE60625 | P4HB | 5034 | 6 | 0 | 5 | |
| GSE74703 | P4HB | 5034 | 3 | 3 | 30 | |
| GSE74704 | P4HB | 5034 | 4 | 3 | 13 | |
| TCGA | P4HB | 5034 | 25 | 12 | 59 |
Total number of gains: 104; Total number of losses: 44; Total Number of normals: 340.
Somatic mutations of P4HB:
Generating mutation plots.
Highly correlated genes for P4HB:
Showing top 20/597 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| P4HB | FBXL5 | 0.763088 | 3 | 0 | 3 |
| P4HB | CNOT11 | 0.741908 | 3 | 0 | 3 |
| P4HB | CDK7 | 0.740866 | 6 | 0 | 6 |
| P4HB | PRDX5 | 0.704105 | 3 | 0 | 3 |
| P4HB | DGAT2 | 0.702436 | 3 | 0 | 3 |
| P4HB | HIPK2 | 0.701408 | 6 | 0 | 6 |
| P4HB | PDIA3 | 0.696436 | 3 | 0 | 3 |
| P4HB | E2F2 | 0.69364 | 3 | 0 | 3 |
| P4HB | ZNF101 | 0.692848 | 3 | 0 | 3 |
| P4HB | MACC1 | 0.691195 | 3 | 0 | 3 |
| P4HB | MFSD1 | 0.687981 | 6 | 0 | 6 |
| P4HB | VPS28 | 0.687893 | 3 | 0 | 3 |
| P4HB | SERINC2 | 0.687811 | 3 | 0 | 3 |
| P4HB | NDUFA10 | 0.687641 | 3 | 0 | 3 |
| P4HB | GRN | 0.67228 | 7 | 0 | 6 |
| P4HB | PFKL | 0.671407 | 6 | 0 | 5 |
| P4HB | PRSS8 | 0.671382 | 7 | 0 | 6 |
| P4HB | DUOX1 | 0.669814 | 6 | 0 | 6 |
| P4HB | SPINT2 | 0.669511 | 6 | 0 | 4 |
| P4HB | ERLIN1 | 0.663131 | 7 | 0 | 6 |
For details and further investigation, click here
