| Full name: kalirin RhoGEF kinase | Alias Symbol: duo|Hs.8004|TRAD|DUET|Kalirin|ARHGEF24 | ||
| Type: protein-coding gene | Cytoband: 3q21.1-q21.2 | ||
| Entrez ID: 8997 | HGNC ID: HGNC:4814 | Ensembl Gene: ENSG00000160145 | OMIM ID: 604605 |
| Drug and gene relationship at DGIdb | |||
Expression of KALRN:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | KALRN | 8997 | 227750_at | -2.0317 | 0.0285 | |
| GSE20347 | KALRN | 8997 | 206078_at | -0.0558 | 0.4404 | |
| GSE23400 | KALRN | 8997 | 206078_at | -0.0726 | 0.0097 | |
| GSE26886 | KALRN | 8997 | 227750_at | -2.8073 | 0.0000 | |
| GSE29001 | KALRN | 8997 | 205635_at | 0.0988 | 0.6250 | |
| GSE38129 | KALRN | 8997 | 206078_at | -0.0859 | 0.2192 | |
| GSE45670 | KALRN | 8997 | 227750_at | -0.7735 | 0.0148 | |
| GSE53622 | KALRN | 8997 | 109340 | -2.2766 | 0.0000 | |
| GSE53624 | KALRN | 8997 | 109340 | -2.5132 | 0.0000 | |
| GSE63941 | KALRN | 8997 | 232756_at | 0.0975 | 0.4943 | |
| GSE77861 | KALRN | 8997 | 227750_at | -1.1264 | 0.0036 | |
| GSE97050 | KALRN | 8997 | A_33_P3219121 | 0.2549 | 0.2969 | |
| SRP007169 | KALRN | 8997 | RNAseq | -0.4433 | 0.4842 | |
| SRP064894 | KALRN | 8997 | RNAseq | -1.5378 | 0.0000 | |
| SRP133303 | KALRN | 8997 | RNAseq | -1.3079 | 0.0005 | |
| SRP159526 | KALRN | 8997 | RNAseq | -1.5133 | 0.0005 | |
| SRP193095 | KALRN | 8997 | RNAseq | -1.3840 | 0.0001 | |
| SRP219564 | KALRN | 8997 | RNAseq | -1.1080 | 0.0545 | |
| TCGA | KALRN | 8997 | RNAseq | -0.9089 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by KALRN expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of KALRN:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | KALRN | 8997 | 17 | 0 | 13 | |
| GSE20123 | KALRN | 8997 | 17 | 0 | 13 | |
| GSE43470 | KALRN | 8997 | 21 | 0 | 22 | |
| GSE46452 | KALRN | 8997 | 14 | 5 | 40 | |
| GSE47630 | KALRN | 8997 | 17 | 4 | 19 | |
| GSE54993 | KALRN | 8997 | 2 | 7 | 61 | |
| GSE54994 | KALRN | 8997 | 31 | 3 | 19 | |
| GSE60625 | KALRN | 8997 | 0 | 6 | 5 | |
| GSE74703 | KALRN | 8997 | 17 | 0 | 19 | |
| GSE74704 | KALRN | 8997 | 13 | 0 | 7 | |
| TCGA | KALRN | 8997 | 55 | 6 | 35 |
Total number of gains: 204; Total number of losses: 31; Total Number of normals: 253.
Somatic mutations of KALRN:
Generating mutation plots.
Highly correlated genes for KALRN:
Showing top 20/1077 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| KALRN | CLIC3 | 0.904899 | 4 | 0 | 4 |
| KALRN | CAPN5 | 0.877259 | 6 | 0 | 6 |
| KALRN | SCNN1B | 0.87292 | 6 | 0 | 6 |
| KALRN | KRT78 | 0.867777 | 6 | 0 | 6 |
| KALRN | SMIM5 | 0.864305 | 6 | 0 | 6 |
| KALRN | VSIG10L | 0.863157 | 6 | 0 | 6 |
| KALRN | CYSRT1 | 0.860575 | 6 | 0 | 6 |
| KALRN | SH3BGRL2 | 0.847357 | 6 | 0 | 6 |
| KALRN | CD24 | 0.845171 | 6 | 0 | 6 |
| KALRN | EPS8L1 | 0.839727 | 6 | 0 | 6 |
| KALRN | SNORA68 | 0.832827 | 4 | 0 | 4 |
| KALRN | TMPRSS11B | 0.832815 | 6 | 0 | 6 |
| KALRN | LRP10 | 0.83011 | 7 | 0 | 7 |
| KALRN | CSTB | 0.829799 | 6 | 0 | 6 |
| KALRN | TMEM40 | 0.829649 | 6 | 0 | 6 |
| KALRN | SFTA2 | 0.828884 | 4 | 0 | 4 |
| KALRN | A2ML1 | 0.827135 | 6 | 0 | 6 |
| KALRN | FAM214A | 0.825972 | 6 | 0 | 6 |
| KALRN | CRISP3 | 0.819145 | 6 | 0 | 6 |
| KALRN | PLEKHM1 | 0.811446 | 7 | 0 | 7 |
For details and further investigation, click here
