| Full name: 3-hydroxy-3-methylglutaryl-CoA lyase | Alias Symbol: HL | ||
| Type: protein-coding gene | Cytoband: 1p36.11 | ||
| Entrez ID: 3155 | HGNC ID: HGNC:5005 | Ensembl Gene: ENSG00000117305 | OMIM ID: 613898 |
| Drug and gene relationship at DGIdb | |||
Expression of HMGCL:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HMGCL | 3155 | 202772_at | -0.3659 | 0.2021 | |
| GSE20347 | HMGCL | 3155 | 202772_at | -0.4373 | 0.0002 | |
| GSE23400 | HMGCL | 3155 | 202772_at | -0.2266 | 0.0000 | |
| GSE26886 | HMGCL | 3155 | 202772_at | -0.9231 | 0.0000 | |
| GSE29001 | HMGCL | 3155 | 202772_at | -0.5506 | 0.0053 | |
| GSE38129 | HMGCL | 3155 | 202772_at | -0.3734 | 0.0001 | |
| GSE45670 | HMGCL | 3155 | 202772_at | -0.2129 | 0.2069 | |
| GSE53622 | HMGCL | 3155 | 43904 | -0.3731 | 0.0000 | |
| GSE53624 | HMGCL | 3155 | 43904 | -0.7992 | 0.0000 | |
| GSE63941 | HMGCL | 3155 | 202772_at | 0.0737 | 0.8858 | |
| GSE77861 | HMGCL | 3155 | 202772_at | -0.4774 | 0.0153 | |
| GSE97050 | HMGCL | 3155 | A_23_P145 | -0.2444 | 0.3526 | |
| SRP007169 | HMGCL | 3155 | RNAseq | -1.7462 | 0.0000 | |
| SRP008496 | HMGCL | 3155 | RNAseq | -1.6383 | 0.0000 | |
| SRP064894 | HMGCL | 3155 | RNAseq | -0.1108 | 0.6529 | |
| SRP133303 | HMGCL | 3155 | RNAseq | -0.2680 | 0.2284 | |
| SRP159526 | HMGCL | 3155 | RNAseq | -0.7660 | 0.0000 | |
| SRP193095 | HMGCL | 3155 | RNAseq | -0.9143 | 0.0000 | |
| SRP219564 | HMGCL | 3155 | RNAseq | -0.4645 | 0.1298 | |
| TCGA | HMGCL | 3155 | RNAseq | -0.3361 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by HMGCL expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HMGCL:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HMGCL | 3155 | 0 | 5 | 25 | |
| GSE20123 | HMGCL | 3155 | 0 | 4 | 26 | |
| GSE43470 | HMGCL | 3155 | 2 | 6 | 35 | |
| GSE46452 | HMGCL | 3155 | 5 | 1 | 53 | |
| GSE47630 | HMGCL | 3155 | 8 | 3 | 29 | |
| GSE54993 | HMGCL | 3155 | 2 | 1 | 67 | |
| GSE54994 | HMGCL | 3155 | 11 | 4 | 38 | |
| GSE60625 | HMGCL | 3155 | 0 | 0 | 11 | |
| GSE74703 | HMGCL | 3155 | 1 | 4 | 31 | |
| GSE74704 | HMGCL | 3155 | 0 | 0 | 20 | |
| TCGA | HMGCL | 3155 | 9 | 24 | 63 |
Total number of gains: 38; Total number of losses: 52; Total Number of normals: 398.
Somatic mutations of HMGCL:
Generating mutation plots.
Highly correlated genes for HMGCL:
Showing top 20/1424 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HMGCL | C15orf41 | 0.810476 | 3 | 0 | 3 |
| HMGCL | RHBDD1 | 0.798155 | 3 | 0 | 3 |
| HMGCL | PRPF38A | 0.779676 | 3 | 0 | 3 |
| HMGCL | ARL16 | 0.753798 | 3 | 0 | 3 |
| HMGCL | COX5A | 0.75219 | 3 | 0 | 3 |
| HMGCL | GPR108 | 0.749482 | 3 | 0 | 3 |
| HMGCL | UBAC2 | 0.74907 | 3 | 0 | 3 |
| HMGCL | PLXNB1 | 0.742908 | 3 | 0 | 3 |
| HMGCL | FBXO8 | 0.741182 | 6 | 0 | 6 |
| HMGCL | PDCD7 | 0.735998 | 3 | 0 | 3 |
| HMGCL | SNORA68 | 0.73578 | 4 | 0 | 4 |
| HMGCL | CLDND1 | 0.722141 | 3 | 0 | 3 |
| HMGCL | RABL3 | 0.713134 | 4 | 0 | 4 |
| HMGCL | TBC1D20 | 0.712411 | 4 | 0 | 4 |
| HMGCL | CCNYL1 | 0.712184 | 4 | 0 | 4 |
| HMGCL | ZNF425 | 0.707126 | 4 | 0 | 3 |
| HMGCL | GLIDR | 0.706596 | 3 | 0 | 3 |
| HMGCL | GLUD2 | 0.705048 | 5 | 0 | 4 |
| HMGCL | CYP4V2 | 0.704878 | 3 | 0 | 3 |
| HMGCL | GGA3 | 0.699972 | 4 | 0 | 3 |
For details and further investigation, click here
