| Full name: cytochrome c oxidase subunit 5A | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 15q24.2 | ||
| Entrez ID: 9377 | HGNC ID: HGNC:2267 | Ensembl Gene: ENSG00000178741 | OMIM ID: 603773 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of COX5A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | COX5A | 9377 | 203663_s_at | -0.2938 | 0.5412 | |
| GSE20347 | COX5A | 9377 | 203663_s_at | -0.2866 | 0.0538 | |
| GSE23400 | COX5A | 9377 | 203663_s_at | -0.2763 | 0.0006 | |
| GSE26886 | COX5A | 9377 | 203663_s_at | 0.0739 | 0.6750 | |
| GSE29001 | COX5A | 9377 | 203663_s_at | -0.6831 | 0.0419 | |
| GSE38129 | COX5A | 9377 | 203663_s_at | -0.0636 | 0.6825 | |
| GSE45670 | COX5A | 9377 | 203663_s_at | -0.2097 | 0.1132 | |
| GSE63941 | COX5A | 9377 | 203663_s_at | 0.7182 | 0.0252 | |
| GSE77861 | COX5A | 9377 | 203663_s_at | -0.2833 | 0.3329 | |
| GSE97050 | COX5A | A_19_P00808453 | -0.4684 | 0.1606 | ||
| SRP007169 | COX5A | 9377 | RNAseq | -1.4829 | 0.0000 | |
| SRP008496 | COX5A | 9377 | RNAseq | -1.5821 | 0.0000 | |
| SRP064894 | COX5A | 9377 | RNAseq | -0.6987 | 0.0047 | |
| SRP133303 | COX5A | 9377 | RNAseq | -0.2219 | 0.2975 | |
| SRP159526 | COX5A | 9377 | RNAseq | -0.0876 | 0.8190 | |
| SRP193095 | COX5A | 9377 | RNAseq | -0.8329 | 0.0000 | |
| SRP219564 | COX5A | 9377 | RNAseq | -0.2610 | 0.5150 | |
| TCGA | COX5A | 9377 | RNAseq | -0.1245 | 0.0332 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by COX5A expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of COX5A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | COX5A | 9377 | 8 | 1 | 21 | |
| GSE20123 | COX5A | 9377 | 8 | 1 | 21 | |
| GSE43470 | COX5A | 9377 | 4 | 6 | 33 | |
| GSE46452 | COX5A | 9377 | 3 | 7 | 49 | |
| GSE47630 | COX5A | 9377 | 8 | 10 | 22 | |
| GSE54993 | COX5A | 9377 | 5 | 6 | 59 | |
| GSE54994 | COX5A | 9377 | 5 | 7 | 41 | |
| GSE60625 | COX5A | 9377 | 4 | 0 | 7 | |
| GSE74703 | COX5A | 9377 | 4 | 3 | 29 | |
| GSE74704 | COX5A | 9377 | 4 | 1 | 15 | |
| TCGA | COX5A | 9377 | 14 | 15 | 67 |
Total number of gains: 67; Total number of losses: 57; Total Number of normals: 364.
Somatic mutations of COX5A:
Generating mutation plots.
Highly correlated genes for COX5A:
Showing top 20/649 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| COX5A | PRPF38A | 0.768432 | 3 | 0 | 3 |
| COX5A | ABHD17C | 0.754132 | 3 | 0 | 3 |
| COX5A | HMGCL | 0.75219 | 3 | 0 | 3 |
| COX5A | ZRANB1 | 0.73813 | 3 | 0 | 3 |
| COX5A | FRS2 | 0.731794 | 3 | 0 | 3 |
| COX5A | SNX7 | 0.711358 | 3 | 0 | 3 |
| COX5A | TMEM109 | 0.707696 | 3 | 0 | 3 |
| COX5A | MLST8 | 0.706005 | 3 | 0 | 3 |
| COX5A | NOA1 | 0.705999 | 3 | 0 | 3 |
| COX5A | CERS3 | 0.705906 | 3 | 0 | 3 |
| COX5A | ZNF398 | 0.704678 | 4 | 0 | 3 |
| COX5A | TMEM218 | 0.701612 | 3 | 0 | 3 |
| COX5A | DCTD | 0.696719 | 3 | 0 | 3 |
| COX5A | ULK3 | 0.693988 | 5 | 0 | 5 |
| COX5A | SIN3A | 0.693723 | 4 | 0 | 4 |
| COX5A | TMED4 | 0.692907 | 4 | 0 | 4 |
| COX5A | KRAS | 0.692602 | 4 | 0 | 3 |
| COX5A | UQCR10 | 0.691255 | 6 | 0 | 5 |
| COX5A | FIS1 | 0.690861 | 3 | 0 | 3 |
| COX5A | CHCHD1 | 0.688667 | 5 | 0 | 4 |
For details and further investigation, click here
