| Full name: TBC1 domain family member 20 | Alias Symbol: dJ852M4.2 | ||
| Type: protein-coding gene | Cytoband: 20p13 | ||
| Entrez ID: 128637 | HGNC ID: HGNC:16133 | Ensembl Gene: ENSG00000125875 | OMIM ID: 611663 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
Expression of TBC1D20:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | TBC1D20 | 128637 | 226409_at | -0.6045 | 0.1621 | |
| GSE26886 | TBC1D20 | 128637 | 226409_at | -1.2384 | 0.0000 | |
| GSE45670 | TBC1D20 | 128637 | 226409_at | -0.2299 | 0.1799 | |
| GSE53622 | TBC1D20 | 128637 | 84498 | -0.0837 | 0.2429 | |
| GSE53624 | TBC1D20 | 128637 | 84498 | -0.1230 | 0.0092 | |
| GSE63941 | TBC1D20 | 128637 | 226409_at | -1.4473 | 0.0120 | |
| GSE77861 | TBC1D20 | 128637 | 226409_at | -0.2677 | 0.1004 | |
| GSE97050 | TBC1D20 | 128637 | A_24_P392958 | -0.2581 | 0.4272 | |
| SRP007169 | TBC1D20 | 128637 | RNAseq | -0.5093 | 0.2336 | |
| SRP008496 | TBC1D20 | 128637 | RNAseq | 0.1081 | 0.7400 | |
| SRP064894 | TBC1D20 | 128637 | RNAseq | -0.3804 | 0.0007 | |
| SRP133303 | TBC1D20 | 128637 | RNAseq | -0.2914 | 0.0541 | |
| SRP159526 | TBC1D20 | 128637 | RNAseq | -0.3830 | 0.0480 | |
| SRP193095 | TBC1D20 | 128637 | RNAseq | -0.3967 | 0.0000 | |
| SRP219564 | TBC1D20 | 128637 | RNAseq | -0.6461 | 0.0125 | |
| TCGA | TBC1D20 | 128637 | RNAseq | -0.1121 | 0.0146 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by TBC1D20 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of TBC1D20:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | TBC1D20 | 128637 | 12 | 4 | 14 | |
| GSE20123 | TBC1D20 | 128637 | 13 | 4 | 13 | |
| GSE43470 | TBC1D20 | 128637 | 11 | 1 | 31 | |
| GSE46452 | TBC1D20 | 128637 | 26 | 1 | 32 | |
| GSE47630 | TBC1D20 | 128637 | 19 | 4 | 17 | |
| GSE54993 | TBC1D20 | 128637 | 2 | 15 | 53 | |
| GSE54994 | TBC1D20 | 128637 | 24 | 2 | 27 | |
| GSE60625 | TBC1D20 | 128637 | 0 | 0 | 11 | |
| GSE74703 | TBC1D20 | 128637 | 10 | 1 | 25 | |
| GSE74704 | TBC1D20 | 128637 | 8 | 2 | 10 | |
| TCGA | TBC1D20 | 128637 | 41 | 11 | 44 |
Total number of gains: 166; Total number of losses: 45; Total Number of normals: 277.
Somatic mutations of TBC1D20:
Generating mutation plots.
Highly correlated genes for TBC1D20:
Showing top 20/911 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| TBC1D20 | ZFC3H1 | 0.815953 | 3 | 0 | 3 |
| TBC1D20 | UBE2J1 | 0.815892 | 3 | 0 | 3 |
| TBC1D20 | OAT | 0.801174 | 3 | 0 | 3 |
| TBC1D20 | SYNE1 | 0.799827 | 3 | 0 | 3 |
| TBC1D20 | PPP1R3B | 0.797361 | 3 | 0 | 3 |
| TBC1D20 | MAP2K1 | 0.795835 | 3 | 0 | 3 |
| TBC1D20 | UBE2E2 | 0.791319 | 3 | 0 | 3 |
| TBC1D20 | TRIM23 | 0.781168 | 3 | 0 | 3 |
| TBC1D20 | ZNF83 | 0.774548 | 3 | 0 | 3 |
| TBC1D20 | ZFAND5 | 0.772563 | 3 | 0 | 3 |
| TBC1D20 | NCOA4 | 0.770179 | 3 | 0 | 3 |
| TBC1D20 | SH3GLB1 | 0.766718 | 4 | 0 | 3 |
| TBC1D20 | GTF2B | 0.765481 | 3 | 0 | 3 |
| TBC1D20 | TMCO4 | 0.765446 | 3 | 0 | 3 |
| TBC1D20 | FNIP1 | 0.763944 | 3 | 0 | 3 |
| TBC1D20 | IRAK2 | 0.762798 | 3 | 0 | 3 |
| TBC1D20 | RND3 | 0.761696 | 3 | 0 | 3 |
| TBC1D20 | SLC25A23 | 0.758651 | 3 | 0 | 3 |
| TBC1D20 | RAPGEF2 | 0.751849 | 3 | 0 | 3 |
| TBC1D20 | COMMD1 | 0.750595 | 3 | 0 | 3 |
For details and further investigation, click here
