| Full name: G protein-coupled receptor 108 | Alias Symbol: LUSTR2 | ||
| Type: protein-coding gene | Cytoband: 19p13.3 | ||
| Entrez ID: 56927 | HGNC ID: HGNC:17829 | Ensembl Gene: ENSG00000125734 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of GPR108:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE53622 | GPR108 | 56927 | 28642 | -0.4804 | 0.0000 | |
| GSE53624 | GPR108 | 56927 | 28642 | -0.5547 | 0.0000 | |
| GSE97050 | GPR108 | 56927 | A_23_P90014 | -0.0068 | 0.9792 | |
| SRP007169 | GPR108 | 56927 | RNAseq | -1.5151 | 0.0002 | |
| SRP008496 | GPR108 | 56927 | RNAseq | -1.3745 | 0.0000 | |
| SRP064894 | GPR108 | 56927 | RNAseq | -0.2466 | 0.1482 | |
| SRP133303 | GPR108 | 56927 | RNAseq | -0.5449 | 0.0001 | |
| SRP159526 | GPR108 | 56927 | RNAseq | -0.5814 | 0.0108 | |
| SRP193095 | GPR108 | 56927 | RNAseq | -0.4538 | 0.0000 | |
| SRP219564 | GPR108 | 56927 | RNAseq | -0.2597 | 0.2441 | |
| TCGA | GPR108 | 56927 | RNAseq | -0.1145 | 0.0178 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by GPR108 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GPR108:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GPR108 | 56927 | 5 | 3 | 22 | |
| GSE20123 | GPR108 | 56927 | 4 | 2 | 24 | |
| GSE43470 | GPR108 | 56927 | 2 | 6 | 35 | |
| GSE46452 | GPR108 | 56927 | 47 | 1 | 11 | |
| GSE47630 | GPR108 | 56927 | 5 | 7 | 28 | |
| GSE54993 | GPR108 | 56927 | 16 | 3 | 51 | |
| GSE54994 | GPR108 | 56927 | 6 | 14 | 33 | |
| GSE60625 | GPR108 | 56927 | 9 | 0 | 2 | |
| GSE74703 | GPR108 | 56927 | 2 | 4 | 30 | |
| GSE74704 | GPR108 | 56927 | 1 | 2 | 17 | |
| TCGA | GPR108 | 56927 | 9 | 19 | 68 |
Total number of gains: 106; Total number of losses: 61; Total Number of normals: 321.
Somatic mutations of GPR108:
Generating mutation plots.
Highly correlated genes for GPR108:
Showing top 20/288 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GPR108 | TMEM19 | 0.800249 | 3 | 0 | 3 |
| GPR108 | NME6 | 0.787743 | 3 | 0 | 3 |
| GPR108 | APEH | 0.787118 | 3 | 0 | 3 |
| GPR108 | TMEM120A | 0.76652 | 3 | 0 | 3 |
| GPR108 | POLD4 | 0.759705 | 3 | 0 | 3 |
| GPR108 | TAOK3 | 0.756578 | 3 | 0 | 3 |
| GPR108 | RAB3D | 0.754148 | 3 | 0 | 3 |
| GPR108 | AP3B1 | 0.753581 | 3 | 0 | 3 |
| GPR108 | HMGCL | 0.749482 | 3 | 0 | 3 |
| GPR108 | MTIF3 | 0.748283 | 3 | 0 | 3 |
| GPR108 | NR2F6 | 0.748169 | 3 | 0 | 3 |
| GPR108 | TMEM59 | 0.746276 | 3 | 0 | 3 |
| GPR108 | NLRX1 | 0.745924 | 3 | 0 | 3 |
| GPR108 | PAQR7 | 0.745407 | 3 | 0 | 3 |
| GPR108 | ANO10 | 0.745224 | 3 | 0 | 3 |
| GPR108 | STXBP5 | 0.744039 | 3 | 0 | 3 |
| GPR108 | TSG101 | 0.74349 | 3 | 0 | 3 |
| GPR108 | KLHL18 | 0.741542 | 3 | 0 | 3 |
| GPR108 | PRKCH | 0.740503 | 3 | 0 | 3 |
| GPR108 | CCDC12 | 0.740162 | 3 | 0 | 3 |
For details and further investigation, click here
