| Full name: hepatocyte nuclear factor 4 alpha | Alias Symbol: NR2A1|HNF4 | ||
| Type: protein-coding gene | Cytoband: 20q13.12 | ||
| Entrez ID: 3172 | HGNC ID: HGNC:5024 | Ensembl Gene: ENSG00000101076 | OMIM ID: 600281 |
| Drug and gene relationship at DGIdb | |||
Screen Evidence:
| |||
HNF4A involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04152 | AMPK signaling pathway | |
| hsa04950 | Maturity onset diabetes of the young |
Expression of HNF4A:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HNF4A | 3172 | 216889_s_at | 0.0844 | 0.6789 | |
| GSE20347 | HNF4A | 3172 | 216889_s_at | 0.0463 | 0.6387 | |
| GSE23400 | HNF4A | 3172 | 208429_x_at | -0.3954 | 0.0000 | |
| GSE26886 | HNF4A | 3172 | 216889_s_at | -0.0773 | 0.5794 | |
| GSE29001 | HNF4A | 3172 | 214851_at | -0.0122 | 0.9358 | |
| GSE38129 | HNF4A | 3172 | 216889_s_at | -0.0812 | 0.2093 | |
| GSE45670 | HNF4A | 3172 | 216889_s_at | 0.0234 | 0.8050 | |
| GSE53622 | HNF4A | 3172 | 40774 | -0.7736 | 0.0000 | |
| GSE53624 | HNF4A | 3172 | 40774 | -0.4281 | 0.0006 | |
| GSE63941 | HNF4A | 3172 | 216889_s_at | -0.1298 | 0.3750 | |
| GSE77861 | HNF4A | 3172 | 216889_s_at | 0.0095 | 0.9315 | |
| GSE97050 | HNF4A | 3172 | A_23_P28761 | -0.1035 | 0.7682 | |
| SRP133303 | HNF4A | 3172 | RNAseq | 0.5779 | 0.0004 | |
| SRP193095 | HNF4A | 3172 | RNAseq | -1.7982 | 0.0031 | |
| TCGA | HNF4A | 3172 | RNAseq | -2.9528 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 2.
Survival by HNF4A expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HNF4A:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HNF4A | 3172 | 13 | 1 | 16 | |
| GSE20123 | HNF4A | 3172 | 13 | 1 | 16 | |
| GSE43470 | HNF4A | 3172 | 12 | 2 | 29 | |
| GSE46452 | HNF4A | 3172 | 29 | 0 | 30 | |
| GSE47630 | HNF4A | 3172 | 25 | 0 | 15 | |
| GSE54993 | HNF4A | 3172 | 0 | 17 | 53 | |
| GSE54994 | HNF4A | 3172 | 25 | 0 | 28 | |
| GSE60625 | HNF4A | 3172 | 0 | 0 | 11 | |
| GSE74703 | HNF4A | 3172 | 10 | 2 | 24 | |
| GSE74704 | HNF4A | 3172 | 9 | 0 | 11 | |
| TCGA | HNF4A | 3172 | 45 | 3 | 48 |
Total number of gains: 181; Total number of losses: 26; Total Number of normals: 281.
Somatic mutations of HNF4A:
Generating mutation plots.
Highly correlated genes for HNF4A:
Showing top 20/613 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HNF4A | UMODL1 | 0.751616 | 3 | 0 | 3 |
| HNF4A | OLIG3 | 0.735795 | 3 | 0 | 3 |
| HNF4A | FMR1NB | 0.708076 | 3 | 0 | 3 |
| HNF4A | NKAIN4 | 0.707035 | 4 | 0 | 3 |
| HNF4A | TMEM179 | 0.696429 | 4 | 0 | 4 |
| HNF4A | CNTD2 | 0.695335 | 6 | 0 | 6 |
| HNF4A | SUN5 | 0.690796 | 3 | 0 | 3 |
| HNF4A | WNT9A | 0.688359 | 3 | 0 | 3 |
| HNF4A | GPR150 | 0.683838 | 4 | 0 | 4 |
| HNF4A | CLCNKA | 0.68137 | 3 | 0 | 3 |
| HNF4A | LRRC46 | 0.675345 | 4 | 0 | 3 |
| HNF4A | KLHL35 | 0.67516 | 4 | 0 | 4 |
| HNF4A | GRIPAP1 | 0.666721 | 3 | 0 | 3 |
| HNF4A | C19orf44 | 0.665074 | 3 | 0 | 3 |
| HNF4A | TDGF1 | 0.662429 | 3 | 0 | 3 |
| HNF4A | CYP2D6 | 0.659492 | 7 | 0 | 6 |
| HNF4A | LRIT1 | 0.655753 | 5 | 0 | 4 |
| HNF4A | ACRV1 | 0.6551 | 6 | 0 | 6 |
| HNF4A | TMEM229A | 0.650937 | 3 | 0 | 3 |
| HNF4A | GABRD | 0.650448 | 4 | 0 | 3 |
For details and further investigation, click here
