| Full name: cytochrome P450 family 2 subfamily D member 6 | Alias Symbol: CPD6|P450-DB1|CYP2D|P450C2D | ||
| Type: protein-coding gene | Cytoband: 22q13.2 | ||
| Entrez ID: 1565 | HGNC ID: HGNC:2625 | Ensembl Gene: ENSG00000100197 | OMIM ID: 124030 |
| Drug and gene relationship at DGIdb | |||
Expression of CYP2D6:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | CYP2D6 | 1565 | 215809_at | -0.0655 | 0.8163 | |
| GSE20347 | CYP2D6 | 1565 | 215809_at | -0.0259 | 0.8322 | |
| GSE23400 | CYP2D6 | 1565 | 215809_at | -0.2272 | 0.0000 | |
| GSE26886 | CYP2D6 | 1565 | 217468_at | 0.0048 | 0.9769 | |
| GSE29001 | CYP2D6 | 1565 | 215809_at | -0.1126 | 0.5925 | |
| GSE38129 | CYP2D6 | 1565 | 215809_at | -0.0819 | 0.4216 | |
| GSE45670 | CYP2D6 | 1565 | 215809_at | 0.1136 | 0.1659 | |
| GSE63941 | CYP2D6 | 1565 | 215809_at | 0.3070 | 0.0683 | |
| GSE77861 | CYP2D6 | 1565 | 215809_at | -0.1037 | 0.3125 | |
| GSE97050 | CYP2D6 | 1565 | A_23_P143734 | -0.4201 | 0.1470 | |
| SRP133303 | CYP2D6 | 1565 | RNAseq | -0.1003 | 0.8457 | |
| SRP159526 | CYP2D6 | 1565 | RNAseq | 0.0888 | 0.9067 | |
| TCGA | CYP2D6 | 1565 | RNAseq | 0.8578 | 0.0061 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by CYP2D6 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of CYP2D6:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | CYP2D6 | 1565 | 6 | 6 | 18 | |
| GSE20123 | CYP2D6 | 1565 | 6 | 5 | 19 | |
| GSE43470 | CYP2D6 | 1565 | 5 | 6 | 32 | |
| GSE46452 | CYP2D6 | 1565 | 31 | 2 | 26 | |
| GSE47630 | CYP2D6 | 1565 | 9 | 4 | 27 | |
| GSE54993 | CYP2D6 | 1565 | 3 | 6 | 61 | |
| GSE54994 | CYP2D6 | 1565 | 11 | 8 | 34 | |
| GSE60625 | CYP2D6 | 1565 | 5 | 0 | 6 | |
| GSE74703 | CYP2D6 | 1565 | 5 | 4 | 27 | |
| GSE74704 | CYP2D6 | 1565 | 3 | 3 | 14 | |
| TCGA | CYP2D6 | 1565 | 28 | 13 | 55 |
Total number of gains: 112; Total number of losses: 57; Total Number of normals: 319.
Somatic mutations of CYP2D6:
Generating mutation plots.
Highly correlated genes for CYP2D6:
Showing top 20/1136 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| CYP2D6 | PGC | 0.80647 | 4 | 0 | 4 |
| CYP2D6 | CALCR | 0.768849 | 5 | 0 | 5 |
| CYP2D6 | IFNA21 | 0.754882 | 4 | 0 | 4 |
| CYP2D6 | CNTD2 | 0.754257 | 7 | 0 | 7 |
| CYP2D6 | BEAN1 | 0.749115 | 4 | 0 | 4 |
| CYP2D6 | USH1C | 0.747405 | 6 | 0 | 6 |
| CYP2D6 | IFNA4 | 0.746791 | 5 | 0 | 5 |
| CYP2D6 | ABCC6 | 0.738425 | 4 | 0 | 4 |
| CYP2D6 | C7orf61 | 0.730289 | 3 | 0 | 3 |
| CYP2D6 | ERN1 | 0.729342 | 5 | 0 | 4 |
| CYP2D6 | CPLX2 | 0.728557 | 3 | 0 | 3 |
| CYP2D6 | RPGRIP1 | 0.725993 | 4 | 0 | 4 |
| CYP2D6 | CAMKV | 0.725409 | 6 | 0 | 6 |
| CYP2D6 | AQP8 | 0.721661 | 6 | 0 | 6 |
| CYP2D6 | RGSL1 | 0.720491 | 4 | 0 | 4 |
| CYP2D6 | NPHS2 | 0.717806 | 5 | 0 | 5 |
| CYP2D6 | KIR3DL3 | 0.717093 | 6 | 0 | 5 |
| CYP2D6 | PTH | 0.71684 | 3 | 0 | 3 |
| CYP2D6 | SEC14L4 | 0.716827 | 5 | 0 | 5 |
| CYP2D6 | MGAT5B | 0.716496 | 3 | 0 | 3 |
For details and further investigation, click here
