| Full name: leucine rich repeat containing 46 | Alias Symbol: MGC16309 | ||
| Type: protein-coding gene | Cytoband: 17q21.32 | ||
| Entrez ID: 90506 | HGNC ID: HGNC:25047 | Ensembl Gene: ENSG00000141294 | OMIM ID: |
| Drug and gene relationship at DGIdb | |||
Expression of LRRC46:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | LRRC46 | 90506 | 230600_at | -0.0894 | 0.7676 | |
| GSE26886 | LRRC46 | 90506 | 230600_at | 0.4834 | 0.0017 | |
| GSE45670 | LRRC46 | 90506 | 230600_at | 0.0852 | 0.4453 | |
| GSE53622 | LRRC46 | 90506 | 38039 | -1.0317 | 0.0000 | |
| GSE53624 | LRRC46 | 90506 | 38039 | -1.2939 | 0.0000 | |
| GSE63941 | LRRC46 | 90506 | 230600_at | -0.0605 | 0.7201 | |
| GSE77861 | LRRC46 | 90506 | 230600_at | -0.0953 | 0.6515 | |
| GSE97050 | LRRC46 | 90506 | A_23_P152949 | -0.4576 | 0.2569 | |
| SRP133303 | LRRC46 | 90506 | RNAseq | 0.3076 | 0.4791 | |
| SRP159526 | LRRC46 | 90506 | RNAseq | 1.4363 | 0.0133 | |
| TCGA | LRRC46 | 90506 | RNAseq | 1.0162 | 0.0001 |
Upregulated datasets: 2; Downregulated datasets: 2.
Survival by LRRC46 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of LRRC46:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | LRRC46 | 90506 | 5 | 2 | 23 | |
| GSE20123 | LRRC46 | 90506 | 5 | 2 | 23 | |
| GSE43470 | LRRC46 | 90506 | 1 | 2 | 40 | |
| GSE46452 | LRRC46 | 90506 | 32 | 0 | 27 | |
| GSE47630 | LRRC46 | 90506 | 9 | 0 | 31 | |
| GSE54993 | LRRC46 | 90506 | 2 | 4 | 64 | |
| GSE54994 | LRRC46 | 90506 | 11 | 5 | 37 | |
| GSE60625 | LRRC46 | 90506 | 4 | 0 | 7 | |
| GSE74703 | LRRC46 | 90506 | 1 | 1 | 34 | |
| GSE74704 | LRRC46 | 90506 | 4 | 1 | 15 | |
| TCGA | LRRC46 | 90506 | 28 | 6 | 62 |
Total number of gains: 102; Total number of losses: 23; Total Number of normals: 363.
Somatic mutations of LRRC46:
Generating mutation plots.
Highly correlated genes for LRRC46:
Showing top 20/197 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| LRRC46 | RASL10B | 0.789235 | 3 | 0 | 3 |
| LRRC46 | LTC4S | 0.782945 | 3 | 0 | 3 |
| LRRC46 | DUSP15 | 0.778093 | 3 | 0 | 3 |
| LRRC46 | CHRNA10 | 0.76264 | 3 | 0 | 3 |
| LRRC46 | MAMLD1 | 0.751332 | 3 | 0 | 3 |
| LRRC46 | UGT2B11 | 0.74882 | 3 | 0 | 3 |
| LRRC46 | ENTPD8 | 0.74434 | 3 | 0 | 3 |
| LRRC46 | DUOXA2 | 0.744263 | 3 | 0 | 3 |
| LRRC46 | TMEM102 | 0.744147 | 3 | 0 | 3 |
| LRRC46 | REG3A | 0.743926 | 5 | 0 | 5 |
| LRRC46 | FOXB1 | 0.743916 | 3 | 0 | 3 |
| LRRC46 | CHST8 | 0.737908 | 3 | 0 | 3 |
| LRRC46 | TUT1 | 0.73751 | 3 | 0 | 3 |
| LRRC46 | RNF151 | 0.735714 | 5 | 0 | 5 |
| LRRC46 | DOK7 | 0.7279 | 3 | 0 | 3 |
| LRRC46 | NKX2-8 | 0.727552 | 4 | 0 | 4 |
| LRRC46 | TM4SF5 | 0.727484 | 3 | 0 | 3 |
| LRRC46 | GRIN1 | 0.725794 | 3 | 0 | 3 |
| LRRC46 | DRD4 | 0.725563 | 3 | 0 | 3 |
| LRRC46 | CDRT15 | 0.720893 | 3 | 0 | 3 |
For details and further investigation, click here
