| Full name: gamma-aminobutyric acid type A receptor delta subunit | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1p36.33 | ||
| Entrez ID: 2563 | HGNC ID: HGNC:4084 | Ensembl Gene: ENSG00000187730 | OMIM ID: 137163 |
| Drug and gene relationship at DGIdb | |||
GABRD involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04727 | GABAergic synapse | |
| hsa05032 | Morphine addiction |
Expression of GABRD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | GABRD | 2563 | 208457_at | 0.2525 | 0.5579 | |
| GSE20347 | GABRD | 2563 | 208457_at | 0.0247 | 0.7732 | |
| GSE23400 | GABRD | 2563 | 208457_at | -0.1165 | 0.0128 | |
| GSE26886 | GABRD | 2563 | 208457_at | 0.1197 | 0.3896 | |
| GSE29001 | GABRD | 2563 | 208457_at | -0.1426 | 0.4213 | |
| GSE38129 | GABRD | 2563 | 208457_at | 0.0740 | 0.4505 | |
| GSE45670 | GABRD | 2563 | 208457_at | -0.0106 | 0.9408 | |
| GSE53622 | GABRD | 2563 | 1460 | 0.2876 | 0.0001 | |
| GSE53624 | GABRD | 2563 | 1460 | 0.4698 | 0.0000 | |
| GSE63941 | GABRD | 2563 | 208457_at | 0.2331 | 0.4438 | |
| GSE77861 | GABRD | 2563 | 208457_at | -0.1249 | 0.2339 | |
| GSE97050 | GABRD | 2563 | A_23_P309720 | 0.0462 | 0.8555 | |
| SRP219564 | GABRD | 2563 | RNAseq | 2.1275 | 0.0020 | |
| TCGA | GABRD | 2563 | RNAseq | 2.5370 | 0.0000 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by GABRD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of GABRD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | GABRD | 2563 | 4 | 7 | 19 | |
| GSE20123 | GABRD | 2563 | 4 | 6 | 20 | |
| GSE43470 | GABRD | 2563 | 3 | 5 | 35 | |
| GSE46452 | GABRD | 2563 | 7 | 1 | 51 | |
| GSE47630 | GABRD | 2563 | 8 | 4 | 28 | |
| GSE54993 | GABRD | 2563 | 2 | 2 | 66 | |
| GSE54994 | GABRD | 2563 | 15 | 2 | 36 | |
| GSE60625 | GABRD | 2563 | 0 | 0 | 11 | |
| GSE74703 | GABRD | 2563 | 3 | 3 | 30 | |
| GSE74704 | GABRD | 2563 | 4 | 0 | 16 | |
| TCGA | GABRD | 2563 | 14 | 20 | 62 |
Total number of gains: 64; Total number of losses: 50; Total Number of normals: 374.
Somatic mutations of GABRD:
Generating mutation plots.
Highly correlated genes for GABRD:
Showing top 20/753 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| GABRD | ICAM3 | 0.845018 | 3 | 0 | 3 |
| GABRD | FMNL1 | 0.751459 | 4 | 0 | 4 |
| GABRD | SV2C | 0.751332 | 3 | 0 | 3 |
| GABRD | SBNO2 | 0.751203 | 3 | 0 | 3 |
| GABRD | ALPL | 0.746307 | 4 | 0 | 3 |
| GABRD | PGC | 0.728606 | 4 | 0 | 3 |
| GABRD | FMR1NB | 0.726689 | 3 | 0 | 3 |
| GABRD | RNF151 | 0.723979 | 3 | 0 | 3 |
| GABRD | CDH22 | 0.719472 | 3 | 0 | 3 |
| GABRD | ADH6 | 0.712322 | 5 | 0 | 4 |
| GABRD | SIRPD | 0.709079 | 3 | 0 | 3 |
| GABRD | PFN4 | 0.707099 | 3 | 0 | 3 |
| GABRD | GH1 | 0.706483 | 4 | 0 | 3 |
| GABRD | CXCR6 | 0.705273 | 3 | 0 | 3 |
| GABRD | TRH | 0.70464 | 4 | 0 | 4 |
| GABRD | AICDA | 0.701319 | 5 | 0 | 4 |
| GABRD | POLD1 | 0.700625 | 3 | 0 | 3 |
| GABRD | PPP1R3F | 0.699174 | 4 | 0 | 3 |
| GABRD | IFNA4 | 0.698523 | 5 | 0 | 4 |
| GABRD | OR2H2 | 0.697122 | 6 | 0 | 6 |
For details and further investigation, click here
