| Full name: heterochromatin protein 1 binding protein 3 | Alias Symbol: HP1-BP74 | ||
| Type: protein-coding gene | Cytoband: 1p36.12 | ||
| Entrez ID: 50809 | HGNC ID: HGNC:24973 | Ensembl Gene: ENSG00000127483 | OMIM ID: 616072 |
| Drug and gene relationship at DGIdb | |||
Expression of HP1BP3:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HP1BP3 | 50809 | 224591_at | -0.1201 | 0.6044 | |
| GSE20347 | HP1BP3 | 50809 | 220633_s_at | 0.3012 | 0.0061 | |
| GSE23400 | HP1BP3 | 50809 | 220633_s_at | 0.1145 | 0.0090 | |
| GSE26886 | HP1BP3 | 50809 | 224591_at | 0.2001 | 0.1857 | |
| GSE29001 | HP1BP3 | 50809 | 220633_s_at | 0.1751 | 0.3396 | |
| GSE38129 | HP1BP3 | 50809 | 220633_s_at | 0.1666 | 0.2616 | |
| GSE45670 | HP1BP3 | 50809 | 224591_at | 0.0719 | 0.5954 | |
| GSE53622 | HP1BP3 | 50809 | 64569 | -0.1311 | 0.0175 | |
| GSE53624 | HP1BP3 | 50809 | 64569 | 0.0667 | 0.1095 | |
| GSE63941 | HP1BP3 | 50809 | 224591_at | -0.2689 | 0.3995 | |
| GSE77861 | HP1BP3 | 50809 | 224591_at | -0.1004 | 0.6686 | |
| GSE97050 | HP1BP3 | 50809 | A_33_P3414695 | -0.1331 | 0.6699 | |
| SRP007169 | HP1BP3 | 50809 | RNAseq | -0.5401 | 0.1164 | |
| SRP008496 | HP1BP3 | 50809 | RNAseq | -0.3276 | 0.0619 | |
| SRP064894 | HP1BP3 | 50809 | RNAseq | 0.2948 | 0.1465 | |
| SRP133303 | HP1BP3 | 50809 | RNAseq | 0.0026 | 0.9810 | |
| SRP159526 | HP1BP3 | 50809 | RNAseq | 0.0630 | 0.8161 | |
| SRP193095 | HP1BP3 | 50809 | RNAseq | 0.1206 | 0.1147 | |
| SRP219564 | HP1BP3 | 50809 | RNAseq | 0.0249 | 0.9236 | |
| TCGA | HP1BP3 | 50809 | RNAseq | 0.0070 | 0.8593 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by HP1BP3 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HP1BP3:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HP1BP3 | 50809 | 0 | 5 | 25 | |
| GSE20123 | HP1BP3 | 50809 | 0 | 4 | 26 | |
| GSE43470 | HP1BP3 | 50809 | 0 | 8 | 35 | |
| GSE46452 | HP1BP3 | 50809 | 5 | 1 | 53 | |
| GSE47630 | HP1BP3 | 50809 | 8 | 3 | 29 | |
| GSE54993 | HP1BP3 | 50809 | 3 | 1 | 66 | |
| GSE54994 | HP1BP3 | 50809 | 11 | 4 | 38 | |
| GSE60625 | HP1BP3 | 50809 | 0 | 0 | 11 | |
| GSE74703 | HP1BP3 | 50809 | 0 | 5 | 31 | |
| GSE74704 | HP1BP3 | 50809 | 0 | 0 | 20 | |
| TCGA | HP1BP3 | 50809 | 9 | 23 | 64 |
Total number of gains: 36; Total number of losses: 54; Total Number of normals: 398.
Somatic mutations of HP1BP3:
Generating mutation plots.
Highly correlated genes for HP1BP3:
Showing top 20/246 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HP1BP3 | UBXN7 | 0.747579 | 3 | 0 | 3 |
| HP1BP3 | EIF1AX | 0.738939 | 3 | 0 | 3 |
| HP1BP3 | UBQLN2 | 0.737724 | 3 | 0 | 3 |
| HP1BP3 | EBAG9 | 0.720066 | 3 | 0 | 3 |
| HP1BP3 | KIAA1143 | 0.718215 | 4 | 0 | 3 |
| HP1BP3 | SRI | 0.703438 | 3 | 0 | 3 |
| HP1BP3 | FRYL | 0.693714 | 4 | 0 | 3 |
| HP1BP3 | ARHGAP35 | 0.692789 | 3 | 0 | 3 |
| HP1BP3 | ATP6V0E2 | 0.68796 | 3 | 0 | 3 |
| HP1BP3 | ZNF227 | 0.686729 | 3 | 0 | 3 |
| HP1BP3 | DUT | 0.684928 | 3 | 0 | 3 |
| HP1BP3 | ZNF136 | 0.680383 | 4 | 0 | 3 |
| HP1BP3 | FAM124A | 0.678973 | 3 | 0 | 3 |
| HP1BP3 | SLC25A36 | 0.678263 | 4 | 0 | 3 |
| HP1BP3 | SRSF4 | 0.676325 | 5 | 0 | 3 |
| HP1BP3 | TSNARE1 | 0.673243 | 4 | 0 | 4 |
| HP1BP3 | GPATCH8 | 0.670689 | 3 | 0 | 3 |
| HP1BP3 | ZNF12 | 0.669524 | 4 | 0 | 3 |
| HP1BP3 | TRAPPC2 | 0.669143 | 4 | 0 | 3 |
| HP1BP3 | LINC00623 | 0.668965 | 3 | 0 | 3 |
For details and further investigation, click here
