ARHGAP35

 

Full name: Rho GTPase activating protein 35 Alias Symbol: GRF-1|p190ARhoGAP|P190A|KIAA1722|p190RhoGAP
Type: protein-coding gene Cytoband: 19q13.32
Entrez ID: 2909 HGNC ID: HGNC:4591 Ensembl Gene: ENSG00000160007 OMIM ID: 605277
Drug and gene relationship at DGIdb
Screen Evidence:
  • Knocking out of this gene by CRIPR/Cas9 screen found 8/325 cell lines had fitness change in Project Score.
  • This gene has been idenfitied as a common driver in this paper.
  • Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

 

ARHGAP35 involved pathways:

KEGG pathway Description View
hsa04510Focal adhesion
hsa04611Platelet activation
hsa04670Leukocyte transendothelial migration
hsa04810Regulation of actin cytoskeleton

 

Expression of ARHGAP35:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 ARHGAP35 2909 229394_s_at 0.0890 0.8605
GSE20347 ARHGAP35 2909 202044_at -0.0057 0.9489
GSE23400 ARHGAP35 2909 202044_at -0.0138 0.7505
GSE26886 ARHGAP35 2909 229394_s_at 0.1614 0.4303
GSE29001 ARHGAP35 2909 202045_s_at 0.0464 0.8880
GSE38129 ARHGAP35 2909 202044_at -0.0672 0.3032
GSE45670 ARHGAP35 2909 229394_s_at -0.1206 0.3759
GSE53622 ARHGAP35 2909 8140 0.0682 0.2908
GSE53624 ARHGAP35 2909 8140 0.1781 0.0019
GSE63941 ARHGAP35 2909 229394_s_at -0.3413 0.4585
GSE77861 ARHGAP35 2909 229394_s_at 0.0607 0.8421
GSE97050 ARHGAP35 2909 A_24_P36299 0.0539 0.9029
SRP007169 ARHGAP35 2909 RNAseq 0.6490 0.0313
SRP008496 ARHGAP35 2909 RNAseq 0.5346 0.0120
SRP064894 ARHGAP35 2909 RNAseq -0.2110 0.1036
SRP133303 ARHGAP35 2909 RNAseq 0.0083 0.9593
SRP159526 ARHGAP35 2909 RNAseq 0.3474 0.1722
SRP193095 ARHGAP35 2909 RNAseq 0.0957 0.2867
SRP219564 ARHGAP35 2909 RNAseq -0.3420 0.1900

Upregulated datasets: 0; Downregulated datasets: 0.  

 

Survival by ARHGAP35 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  

Copy number change of ARHGAP35:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 ARHGAP35 2909 4 4 22
GSE20123 ARHGAP35 2909 4 3 23
GSE43470 ARHGAP35 2909 3 11 29
GSE46452 ARHGAP35 2909 45 1 13
GSE47630 ARHGAP35 2909 8 7 25
GSE54993 ARHGAP35 2909 17 4 49
GSE54994 ARHGAP35 2909 5 14 34
GSE60625 ARHGAP35 2909 9 0 2
GSE74703 ARHGAP35 2909 3 7 26
GSE74704 ARHGAP35 2909 4 1 15
TCGA ARHGAP35 2909 15 17 64

Total number of gains: 117; Total number of losses: 69; Total Number of normals: 302.  

 

Somatic mutations of ARHGAP35:

 

Generating mutation plots.

 

Highly correlated genes for ARHGAP35:

 

Showing top 20/223 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
ARHGAP35GTPBP10.794762303
ARHGAP35RNASEH2B0.7583303
ARHGAP35ZNF1550.750105303
ARHGAP35ERGIC10.746034303
ARHGAP35ZNF518B0.744533303
ARHGAP35TRIM80.738229303
ARHGAP35SYNE20.738064303
ARHGAP35NUDT190.737686303
ARHGAP35ZC3HAV10.730992303
ARHGAP35ZNF1460.723266303
ARHGAP35JTB0.719766303
ARHGAP35GPR1070.716428404
ARHGAP35RNF40.716239303
ARHGAP35ZNF1210.715515303
ARHGAP35CYTH20.711944403
ARHGAP35RRAGC0.711845303
ARHGAP35PAIP10.709285303
ARHGAP35ARID20.702572303
ARHGAP35GTPBP60.700927303
ARHGAP35MYH30.698482303

For details and further investigation, click here