SRSF4

 

Full name: serine and arginine rich splicing factor 4 Alias Symbol: SRP75
Type: protein-coding gene Cytoband: 1p35.3
Entrez ID: 6429 HGNC ID: HGNC:10786 Ensembl Gene: ENSG00000116350 OMIM ID: 601940
Drug and gene relationship at DGIdb

 

SRSF4 involved pathways:

KEGG pathway Description View
hsa05168Herpes simplex infection

 

Expression of SRSF4:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 SRSF4 6429 201696_at -0.1697 0.5825
GSE20347 SRSF4 6429 201696_at -0.0995 0.4504
GSE23400 SRSF4 6429 201696_at 0.1266 0.0589
GSE26886 SRSF4 6429 201696_at -0.2336 0.2039
GSE29001 SRSF4 6429 201696_at 0.0768 0.6864
GSE38129 SRSF4 6429 201696_at -0.1595 0.1157
GSE45670 SRSF4 6429 201696_at -0.2248 0.0240
GSE53622 SRSF4 6429 8655 -0.1282 0.0052
GSE53624 SRSF4 6429 8655 0.0009 0.9875
GSE63941 SRSF4 6429 201696_at 0.1712 0.5879
GSE77861 SRSF4 6429 201696_at 0.0105 0.9629
GSE97050 SRSF4 6429 A_23_P126197 -0.4049 0.1726
SRP007169 SRSF4 6429 RNAseq 0.2094 0.6157
SRP008496 SRSF4 6429 RNAseq 0.1075 0.7159
SRP064894 SRSF4 6429 RNAseq 0.0858 0.5914
SRP133303 SRSF4 6429 RNAseq 0.0277 0.8261
SRP159526 SRSF4 6429 RNAseq -0.0331 0.9155
SRP193095 SRSF4 6429 RNAseq -0.0614 0.5698
SRP219564 SRSF4 6429 RNAseq -0.1089 0.5968

Upregulated datasets: 0; Downregulated datasets: 0.  


 

Survival by SRSF4 expression:

 

GSE53622GSE53624

 

Note: Click image to view full size file.  


Copy number change of SRSF4:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 SRSF4 6429 0 6 24
GSE20123 SRSF4 6429 0 5 25
GSE43470 SRSF4 6429 3 6 34
GSE46452 SRSF4 6429 5 1 53
GSE47630 SRSF4 6429 8 3 29
GSE54993 SRSF4 6429 2 1 67
GSE54994 SRSF4 6429 10 4 39
GSE60625 SRSF4 6429 0 0 11
GSE74703 SRSF4 6429 2 4 30
GSE74704 SRSF4 6429 0 0 20
TCGA SRSF4 6429 11 21 64

Total number of gains: 41; Total number of losses: 51; Total Number of normals: 396.  


 

Somatic mutations of SRSF4:

 

Generating mutation plots.

 

Highly correlated genes for SRSF4:

 

Showing top 20/228 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
SRSF4ARIH20.785335303
SRSF4DDX170.745365303
SRSF4NDUFA80.740307303
SRSF4PTAR10.739001404
SRSF4FRY0.71726303
SRSF4LSM110.713359403
SRSF4PINK10.705297303
SRSF4UBQLN10.702261303
SRSF4MACROD20.692621303
SRSF4RPL37A0.684681303
SRSF4MKRN20.683682303
SRSF4SERTAD10.682325303
SRSF4XK0.681579403
SRSF4ZNF6640.679051303
SRSF4HP1BP30.676325503
SRSF4NACC20.67224504
SRSF4ZYG11B0.671405504
SRSF4HNRNPA10.671337403
SRSF4ARL6IP40.669507403
SRSF4ZNF8440.668951303

For details and further investigation, click here