Full name: deoxyuridine triphosphatase	Alias Symbol: dUTPase
Type: protein-coding gene	Cytoband: 15q21.1
Entrez ID: 1854	HGNC ID: HGNC:3078	Ensembl Gene: ENSG00000128951	OMIM ID: 601266
Drug and gene relationship at DGIdb
Screen Evidence: Knocking out of this gene by CRIPR/Cas9 screen found altered tolerance on DNA toxicity in Genotoxic Screens.

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Expression of DUT:

 

Dataset	Gene	EntrezID	Probe	Log2FC	Adj.pValue	Expression
GSE17351	DUT	1854	208956_x_at	0.2235	0.5858	Show
GSE20347	DUT	1854	208956_x_at	0.6137	0.0000	Show
GSE23400	DUT	1854	208956_x_at	0.5387	0.0000	Show
GSE26886	DUT	1854	208956_x_at	0.8474	0.0000	Show
GSE29001	DUT	1854	208956_x_at	0.5462	0.0022	Show
GSE38129	DUT	1854	208956_x_at	0.5755	0.0005	Show
GSE45670	DUT	1854	208956_x_at	0.1401	0.4051	Show
GSE53622	DUT	1854	68923	0.4132	0.0000	Show
GSE53624	DUT	1854	68923	0.5929	0.0000	Show
GSE63941	DUT	1854	208956_x_at	0.8729	0.0040	Show
GSE77861	DUT	1854	208956_x_at	0.4922	0.0779	Show
GSE97050	DUT	1854	A_23_P88484	-0.0728	0.7599	Show
SRP007169	DUT	1854	RNAseq	0.3135	0.3520	Show
SRP008496	DUT	1854	RNAseq	0.2393	0.2302	Show
SRP064894	DUT	1854	RNAseq	0.4041	0.0163	Show
SRP133303	DUT	1854	RNAseq	0.4390	0.0229	Show
SRP159526	DUT	1854	RNAseq	0.2542	0.2616	Show
SRP193095	DUT	1854	RNAseq	0.1219	0.3135	Show
SRP219564	DUT	1854	RNAseq	0.3791	0.2278	Show
TCGA	DUT	1854	RNAseq	0.2702	0.0000	Show

Upregulated datasets: 0; Downregulated datasets: 0.  Download Data

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Survival by DUT expression:

 

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Copy number change of DUT:

 

Dataset	Gene	EntrezID	Gain	Loss	Normal	Detail
GSE15526	DUT	1854	5	3	22	Show
GSE20123	DUT	1854	5	3	22	Show
GSE43470	DUT	1854	5	4	34	Show
GSE46452	DUT	1854	3	7	49	Show
GSE47630	DUT	1854	8	10	22	Show
GSE54993	DUT	1854	4	6	60	Show
GSE54994	DUT	1854	5	7	41	Show
GSE60625	DUT	1854	4	0	7	Show
GSE74703	DUT	1854	5	3	28	Show
GSE74704	DUT	1854	2	3	15	Show
TCGA	DUT	1854	10	18	68	Show

Total number of gains: 56; Total number of losses: 64; Total Number of normals: 368.  Download Data

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Somatic mutations of DUT:

 

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Highly correlated genes for DUT:

 

Showing top 20/1359 corelated genes with mean PCC>0.5.

Gene1	Gene2	Mean PCC	Num. Datasets	Num. PCC<0	Num. PCC>0.5
DUT	RNF26	0.827184	3	0	3
DUT	B3GALNT2	0.778962	3	0	3
DUT	ANKS6	0.778262	3	0	3
DUT	TMEM205	0.773259	3	0	3
DUT	COPB1	0.769149	3	0	3
DUT	HES4	0.7681	3	0	3
DUT	MRPL38	0.766067	3	0	3
DUT	SRGAP1	0.761297	3	0	3
DUT	RPL22L1	0.757594	3	0	3
DUT	ZBTB8A	0.757398	3	0	3
DUT	TRIM47	0.752268	3	0	3
DUT	TXLNG	0.74948	3	0	3
DUT	WDR81	0.744915	3	0	3
DUT	CEP120	0.741275	3	0	3
DUT	SSBP4	0.733064	3	0	3
DUT	FBXL19	0.72686	3	0	3
DUT	PET117	0.723249	4	0	4
DUT	ADCK2	0.716123	3	0	3
DUT	RPS19BP1	0.71459	4	0	3
DUT	LSM10	0.708919	4	0	3

For details and further investigation, click here