| Full name: inhibitor of DNA binding 4, HLH protein | Alias Symbol: bHLHb27 | ||
| Type: protein-coding gene | Cytoband: 6p22.3 | ||
| Entrez ID: 3400 | HGNC ID: HGNC:5363 | Ensembl Gene: ENSG00000172201 | OMIM ID: 600581 |
| Drug and gene relationship at DGIdb | |||
ID4 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04550 | Signaling pathways regulating pluripotency of stem cells |
Expression of ID4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | ID4 | 3400 | 209291_at | -1.9771 | 0.0567 | |
| GSE20347 | ID4 | 3400 | 209291_at | -2.3774 | 0.0000 | |
| GSE23400 | ID4 | 3400 | 209291_at | -1.7737 | 0.0000 | |
| GSE26886 | ID4 | 3400 | 209291_at | -2.5705 | 0.0000 | |
| GSE29001 | ID4 | 3400 | 209291_at | -2.9828 | 0.0000 | |
| GSE38129 | ID4 | 3400 | 209291_at | -2.1783 | 0.0000 | |
| GSE45670 | ID4 | 3400 | 209291_at | -2.2009 | 0.0000 | |
| GSE63941 | ID4 | 3400 | 209291_at | -2.5170 | 0.1927 | |
| GSE77861 | ID4 | 3400 | 209291_at | -1.5006 | 0.0266 | |
| GSE97050 | ID4 | 3400 | A_33_P3229370 | -1.1741 | 0.0820 | |
| SRP007169 | ID4 | 3400 | RNAseq | -2.8707 | 0.0000 | |
| SRP008496 | ID4 | 3400 | RNAseq | -2.6114 | 0.0000 | |
| SRP064894 | ID4 | 3400 | RNAseq | -1.5471 | 0.0000 | |
| SRP133303 | ID4 | 3400 | RNAseq | -1.5634 | 0.0006 | |
| SRP159526 | ID4 | 3400 | RNAseq | -0.7323 | 0.1972 | |
| SRP193095 | ID4 | 3400 | RNAseq | -1.5219 | 0.0000 | |
| SRP219564 | ID4 | 3400 | RNAseq | -1.2030 | 0.0273 | |
| TCGA | ID4 | 3400 | RNAseq | -0.5835 | 0.0001 |
Upregulated datasets: 0; Downregulated datasets: 13.
Survival by ID4 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of ID4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | ID4 | 3400 | 3 | 5 | 22 | |
| GSE20123 | ID4 | 3400 | 3 | 5 | 22 | |
| GSE43470 | ID4 | 3400 | 9 | 0 | 34 | |
| GSE46452 | ID4 | 3400 | 2 | 9 | 48 | |
| GSE47630 | ID4 | 3400 | 10 | 4 | 26 | |
| GSE54993 | ID4 | 3400 | 1 | 1 | 68 | |
| GSE54994 | ID4 | 3400 | 11 | 3 | 39 | |
| GSE60625 | ID4 | 3400 | 0 | 1 | 10 | |
| GSE74703 | ID4 | 3400 | 8 | 0 | 28 | |
| GSE74704 | ID4 | 3400 | 1 | 1 | 18 | |
| TCGA | ID4 | 3400 | 18 | 23 | 55 |
Total number of gains: 66; Total number of losses: 52; Total Number of normals: 370.
Somatic mutations of ID4:
Generating mutation plots.
Highly correlated genes for ID4:
Showing top 20/1555 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| ID4 | MYOCD | 0.854019 | 3 | 0 | 3 |
| ID4 | XKR4 | 0.830405 | 3 | 0 | 3 |
| ID4 | MTMR10 | 0.827552 | 5 | 0 | 5 |
| ID4 | ZMAT1 | 0.827263 | 3 | 0 | 3 |
| ID4 | RNF150 | 0.82075 | 3 | 0 | 3 |
| ID4 | CTTNBP2 | 0.810049 | 4 | 0 | 4 |
| ID4 | ZNF844 | 0.808349 | 5 | 0 | 5 |
| ID4 | BOC | 0.807101 | 4 | 0 | 4 |
| ID4 | ZNF662 | 0.805695 | 5 | 0 | 5 |
| ID4 | KLHL15 | 0.79586 | 3 | 0 | 3 |
| ID4 | HPGD | 0.794578 | 9 | 0 | 9 |
| ID4 | EIF4E3 | 0.793518 | 5 | 0 | 5 |
| ID4 | SH3BGRL2 | 0.790821 | 5 | 0 | 5 |
| ID4 | SORBS2 | 0.789045 | 9 | 0 | 9 |
| ID4 | RBPMS | 0.788519 | 10 | 0 | 10 |
| ID4 | PTGIS | 0.786983 | 4 | 0 | 4 |
| ID4 | SMOC2 | 0.786541 | 3 | 0 | 3 |
| ID4 | CYP4V2 | 0.781412 | 3 | 0 | 3 |
| ID4 | HLF | 0.775173 | 9 | 0 | 9 |
| ID4 | FBXO10 | 0.772654 | 3 | 0 | 3 |
For details and further investigation, click here
