| Full name: BOC cell adhesion associated, oncogene regulated | Alias Symbol: CDON2 | ||
| Type: protein-coding gene | Cytoband: 3q13.2 | ||
| Entrez ID: 91653 | HGNC ID: HGNC:17173 | Ensembl Gene: ENSG00000144857 | OMIM ID: 608708 |
| Drug and gene relationship at DGIdb | |||
BOC involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04340 | Hedgehog signaling pathway | |
| hsa04360 | Axon guidance |
Expression of BOC:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | BOC | 91653 | 225990_at | -1.8371 | 0.0445 | |
| GSE26886 | BOC | 91653 | 225990_at | -0.2384 | 0.6283 | |
| GSE45670 | BOC | 91653 | 225990_at | -2.2355 | 0.0000 | |
| GSE53622 | BOC | 91653 | 1090 | -1.7437 | 0.0000 | |
| GSE53624 | BOC | 91653 | 1090 | -1.6628 | 0.0000 | |
| GSE63941 | BOC | 91653 | 224184_s_at | -1.1296 | 0.0060 | |
| GSE77861 | BOC | 91653 | 224184_s_at | -0.7630 | 0.0007 | |
| GSE97050 | BOC | 91653 | A_23_P257763 | -0.6193 | 0.1760 | |
| SRP007169 | BOC | 91653 | RNAseq | -2.1697 | 0.0000 | |
| SRP008496 | BOC | 91653 | RNAseq | -1.1365 | 0.0288 | |
| SRP064894 | BOC | 91653 | RNAseq | -0.6897 | 0.0473 | |
| SRP133303 | BOC | 91653 | RNAseq | -2.1360 | 0.0000 | |
| SRP159526 | BOC | 91653 | RNAseq | -0.7090 | 0.1709 | |
| SRP193095 | BOC | 91653 | RNAseq | -2.1373 | 0.0000 | |
| SRP219564 | BOC | 91653 | RNAseq | -0.7595 | 0.3527 | |
| TCGA | BOC | 91653 | RNAseq | -0.4123 | 0.0119 |
Upregulated datasets: 0; Downregulated datasets: 9.
Survival by BOC expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of BOC:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | BOC | 91653 | 16 | 1 | 13 | |
| GSE20123 | BOC | 91653 | 16 | 1 | 13 | |
| GSE43470 | BOC | 91653 | 20 | 1 | 22 | |
| GSE46452 | BOC | 91653 | 13 | 5 | 41 | |
| GSE47630 | BOC | 91653 | 16 | 6 | 18 | |
| GSE54993 | BOC | 91653 | 2 | 6 | 62 | |
| GSE54994 | BOC | 91653 | 29 | 4 | 20 | |
| GSE60625 | BOC | 91653 | 0 | 6 | 5 | |
| GSE74703 | BOC | 91653 | 16 | 1 | 19 | |
| GSE74704 | BOC | 91653 | 12 | 1 | 7 | |
| TCGA | BOC | 91653 | 52 | 7 | 37 |
Total number of gains: 192; Total number of losses: 39; Total Number of normals: 257.
Somatic mutations of BOC:
Generating mutation plots.
Highly correlated genes for BOC:
Showing top 20/1332 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| BOC | CHRDL1 | 0.838044 | 4 | 0 | 4 |
| BOC | RAB9B | 0.820176 | 5 | 0 | 5 |
| BOC | PCP4 | 0.816874 | 5 | 0 | 5 |
| BOC | PPP1R12B | 0.812489 | 5 | 0 | 5 |
| BOC | MAMDC2 | 0.81142 | 5 | 0 | 5 |
| BOC | NFIX | 0.808247 | 7 | 0 | 7 |
| BOC | ID4 | 0.807101 | 4 | 0 | 4 |
| BOC | DAAM2 | 0.79853 | 3 | 0 | 3 |
| BOC | HSPB6 | 0.794573 | 4 | 0 | 4 |
| BOC | C7 | 0.788038 | 5 | 0 | 5 |
| BOC | ARHGAP44 | 0.785958 | 3 | 0 | 3 |
| BOC | CYP21A2 | 0.782296 | 3 | 0 | 3 |
| BOC | APOD | 0.781239 | 5 | 0 | 5 |
| BOC | DES | 0.780671 | 5 | 0 | 5 |
| BOC | TNS1 | 0.777331 | 7 | 0 | 6 |
| BOC | CGNL1 | 0.77661 | 6 | 0 | 6 |
| BOC | XKR4 | 0.773795 | 5 | 0 | 5 |
| BOC | SNORA68 | 0.771408 | 3 | 0 | 3 |
| BOC | CXCL12 | 0.769222 | 6 | 0 | 6 |
| BOC | MYOCD | 0.766528 | 6 | 0 | 6 |
For details and further investigation, click here
