| Full name: sorbin and SH3 domain containing 2 | Alias Symbol: ARGBP2|KIAA0777 | ||
| Type: protein-coding gene | Cytoband: 4q35.1 | ||
| Entrez ID: 8470 | HGNC ID: HGNC:24098 | Ensembl Gene: ENSG00000154556 | OMIM ID: 616349 |
| Drug and gene relationship at DGIdb | |||
Expression of SORBS2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SORBS2 | 8470 | 204288_s_at | -1.9884 | 0.1218 | |
| GSE20347 | SORBS2 | 8470 | 204288_s_at | -2.0799 | 0.0000 | |
| GSE23400 | SORBS2 | 8470 | 204288_s_at | -1.4610 | 0.0000 | |
| GSE26886 | SORBS2 | 8470 | 225728_at | -2.8967 | 0.0001 | |
| GSE29001 | SORBS2 | 8470 | 204288_s_at | -1.5251 | 0.0000 | |
| GSE38129 | SORBS2 | 8470 | 204288_s_at | -2.8665 | 0.0000 | |
| GSE45670 | SORBS2 | 8470 | 225728_at | -2.7999 | 0.0000 | |
| GSE53622 | SORBS2 | 8470 | 136801 | -3.5084 | 0.0000 | |
| GSE53624 | SORBS2 | 8470 | 136801 | -3.3064 | 0.0000 | |
| GSE63941 | SORBS2 | 8470 | 204288_s_at | -0.0739 | 0.9624 | |
| GSE77861 | SORBS2 | 8470 | 204288_s_at | -1.3522 | 0.0033 | |
| GSE97050 | SORBS2 | 8470 | A_24_P140475 | -1.8951 | 0.0903 | |
| SRP007169 | SORBS2 | 8470 | RNAseq | -3.9615 | 0.0000 | |
| SRP008496 | SORBS2 | 8470 | RNAseq | -3.2342 | 0.0000 | |
| SRP064894 | SORBS2 | 8470 | RNAseq | -2.1234 | 0.0000 | |
| SRP133303 | SORBS2 | 8470 | RNAseq | -2.2148 | 0.0001 | |
| SRP159526 | SORBS2 | 8470 | RNAseq | -3.2489 | 0.0000 | |
| SRP193095 | SORBS2 | 8470 | RNAseq | -1.3240 | 0.0006 | |
| SRP219564 | SORBS2 | 8470 | RNAseq | -2.0331 | 0.0423 | |
| TCGA | SORBS2 | 8470 | RNAseq | -1.4445 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 17.
Survival by SORBS2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SORBS2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SORBS2 | 8470 | 2 | 12 | 16 | |
| GSE20123 | SORBS2 | 8470 | 2 | 12 | 16 | |
| GSE43470 | SORBS2 | 8470 | 1 | 14 | 28 | |
| GSE46452 | SORBS2 | 8470 | 1 | 36 | 22 | |
| GSE47630 | SORBS2 | 8470 | 0 | 22 | 18 | |
| GSE54993 | SORBS2 | 8470 | 10 | 0 | 60 | |
| GSE54994 | SORBS2 | 8470 | 3 | 12 | 38 | |
| GSE60625 | SORBS2 | 8470 | 0 | 0 | 11 | |
| GSE74703 | SORBS2 | 8470 | 1 | 11 | 24 | |
| GSE74704 | SORBS2 | 8470 | 1 | 6 | 13 | |
| TCGA | SORBS2 | 8470 | 11 | 33 | 52 |
Total number of gains: 32; Total number of losses: 158; Total Number of normals: 298.
Somatic mutations of SORBS2:
Generating mutation plots.
Highly correlated genes for SORBS2:
Showing top 20/1951 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SORBS2 | ANGPTL1 | 0.848603 | 5 | 0 | 5 |
| SORBS2 | SORCS1 | 0.829082 | 4 | 0 | 4 |
| SORBS2 | SYNPO2 | 0.817634 | 5 | 0 | 5 |
| SORBS2 | PLAC9 | 0.816663 | 6 | 0 | 6 |
| SORBS2 | MAMDC2 | 0.809323 | 6 | 0 | 6 |
| SORBS2 | XKR4 | 0.805018 | 5 | 0 | 5 |
| SORBS2 | SHROOM3 | 0.799599 | 7 | 0 | 7 |
| SORBS2 | NEGR1 | 0.799158 | 5 | 0 | 5 |
| SORBS2 | RNF150 | 0.795685 | 5 | 0 | 5 |
| SORBS2 | RBPMS | 0.79417 | 11 | 0 | 11 |
| SORBS2 | MEIS1 | 0.793716 | 11 | 0 | 11 |
| SORBS2 | GPD1L | 0.790032 | 11 | 0 | 11 |
| SORBS2 | ID4 | 0.789045 | 9 | 0 | 9 |
| SORBS2 | NFIA | 0.787427 | 7 | 0 | 7 |
| SORBS2 | RASSF3 | 0.786533 | 5 | 0 | 5 |
| SORBS2 | C1QTNF7 | 0.776797 | 6 | 0 | 6 |
| SORBS2 | GGA3 | 0.77523 | 3 | 0 | 3 |
| SORBS2 | HSPB8 | 0.773518 | 11 | 0 | 11 |
| SORBS2 | KAT2B | 0.771982 | 11 | 0 | 11 |
| SORBS2 | GNA14 | 0.769361 | 11 | 0 | 11 |
For details and further investigation, click here
