| Full name: HLF transcription factor, PAR bZIP family member | Alias Symbol: MGC33822 | ||
| Type: protein-coding gene | Cytoband: 17q22 | ||
| Entrez ID: 3131 | HGNC ID: HGNC:4977 | Ensembl Gene: ENSG00000108924 | OMIM ID: 142385 |
| Drug and gene relationship at DGIdb | |||
Expression of HLF:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HLF | 3131 | 204753_s_at | -2.4109 | 0.0853 | |
| GSE20347 | HLF | 3131 | 204755_x_at | -2.1726 | 0.0000 | |
| GSE23400 | HLF | 3131 | 204755_x_at | -1.2691 | 0.0000 | |
| GSE26886 | HLF | 3131 | 204755_x_at | -3.1770 | 0.0000 | |
| GSE29001 | HLF | 3131 | 204755_x_at | -2.2811 | 0.0000 | |
| GSE38129 | HLF | 3131 | 204753_s_at | -2.0514 | 0.0000 | |
| GSE45670 | HLF | 3131 | 204753_s_at | -2.0226 | 0.0010 | |
| GSE53622 | HLF | 3131 | 79800 | -2.3926 | 0.0000 | |
| GSE53624 | HLF | 3131 | 79800 | -2.2016 | 0.0000 | |
| GSE63941 | HLF | 3131 | 204754_at | 0.0692 | 0.7356 | |
| GSE77861 | HLF | 3131 | 204753_s_at | -1.1746 | 0.0387 | |
| GSE97050 | HLF | 3131 | A_33_P3400578 | -2.1154 | 0.0555 | |
| SRP007169 | HLF | 3131 | RNAseq | -2.0293 | 0.0062 | |
| SRP008496 | HLF | 3131 | RNAseq | -2.2305 | 0.0000 | |
| SRP064894 | HLF | 3131 | RNAseq | -2.0458 | 0.0000 | |
| SRP133303 | HLF | 3131 | RNAseq | -1.4538 | 0.0089 | |
| SRP159526 | HLF | 3131 | RNAseq | -2.3542 | 0.0000 | |
| SRP193095 | HLF | 3131 | RNAseq | -2.3306 | 0.0000 | |
| SRP219564 | HLF | 3131 | RNAseq | -0.6482 | 0.5783 | |
| TCGA | HLF | 3131 | RNAseq | -0.6243 | 0.0302 |
Upregulated datasets: 0; Downregulated datasets: 15.
Survival by HLF expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HLF:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HLF | 3131 | 4 | 1 | 25 | |
| GSE20123 | HLF | 3131 | 4 | 1 | 25 | |
| GSE43470 | HLF | 3131 | 2 | 1 | 40 | |
| GSE46452 | HLF | 3131 | 32 | 0 | 27 | |
| GSE47630 | HLF | 3131 | 7 | 1 | 32 | |
| GSE54993 | HLF | 3131 | 2 | 4 | 64 | |
| GSE54994 | HLF | 3131 | 9 | 5 | 39 | |
| GSE60625 | HLF | 3131 | 4 | 0 | 7 | |
| GSE74703 | HLF | 3131 | 2 | 1 | 33 | |
| GSE74704 | HLF | 3131 | 3 | 1 | 16 | |
| TCGA | HLF | 3131 | 27 | 7 | 62 |
Total number of gains: 96; Total number of losses: 22; Total Number of normals: 370.
Somatic mutations of HLF:
Generating mutation plots.
Highly correlated genes for HLF:
Showing top 20/1801 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HLF | CLEC3B | 0.863476 | 3 | 0 | 3 |
| HLF | SORCS1 | 0.856303 | 4 | 0 | 4 |
| HLF | CYP21A2 | 0.839127 | 3 | 0 | 3 |
| HLF | SYNPO2 | 0.822873 | 5 | 0 | 5 |
| HLF | RAB9B | 0.8093 | 5 | 0 | 5 |
| HLF | MEIS1 | 0.806451 | 11 | 0 | 11 |
| HLF | EIF4E3 | 0.805487 | 7 | 0 | 7 |
| HLF | NEGR1 | 0.800815 | 5 | 0 | 5 |
| HLF | MAMDC2 | 0.798515 | 6 | 0 | 6 |
| HLF | MYOCD | 0.794931 | 5 | 0 | 5 |
| HLF | CTTNBP2 | 0.79492 | 6 | 0 | 6 |
| HLF | MRVI1 | 0.790679 | 5 | 0 | 5 |
| HLF | CGNL1 | 0.789087 | 7 | 0 | 7 |
| HLF | GPD1L | 0.785961 | 12 | 0 | 11 |
| HLF | HSPB6 | 0.782746 | 6 | 0 | 5 |
| HLF | ID4 | 0.775173 | 9 | 0 | 9 |
| HLF | TGFBR3 | 0.772438 | 10 | 0 | 9 |
| HLF | ARL1 | 0.768959 | 10 | 0 | 10 |
| HLF | SORBS2 | 0.766763 | 11 | 0 | 11 |
| HLF | MTMR10 | 0.765647 | 7 | 0 | 7 |
For details and further investigation, click here
