| Full name: 15-hydroxyprostaglandin dehydrogenase | Alias Symbol: SDR36C1 | ||
| Type: protein-coding gene | Cytoband: 4q34.1 | ||
| Entrez ID: 3248 | HGNC ID: HGNC:5154 | Ensembl Gene: ENSG00000164120 | OMIM ID: 601688 |
| Drug and gene relationship at DGIdb | |||
Expression of HPGD:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | HPGD | 3248 | 203914_x_at | -3.4522 | 0.0573 | |
| GSE20347 | HPGD | 3248 | 203914_x_at | -4.4861 | 0.0000 | |
| GSE23400 | HPGD | 3248 | 203914_x_at | -2.6015 | 0.0000 | |
| GSE26886 | HPGD | 3248 | 203914_x_at | -4.7509 | 0.0000 | |
| GSE29001 | HPGD | 3248 | 203914_x_at | -3.7956 | 0.0000 | |
| GSE38129 | HPGD | 3248 | 203914_x_at | -3.9006 | 0.0000 | |
| GSE45670 | HPGD | 3248 | 203914_x_at | -2.9754 | 0.0002 | |
| GSE53622 | HPGD | 3248 | 95431 | -3.9755 | 0.0000 | |
| GSE53624 | HPGD | 3248 | 95431 | -4.3944 | 0.0000 | |
| GSE63941 | HPGD | 3248 | 203914_x_at | 2.1918 | 0.1780 | |
| GSE77861 | HPGD | 3248 | 203914_x_at | -4.1317 | 0.0011 | |
| GSE97050 | HPGD | 3248 | A_24_P71904 | -1.9187 | 0.0620 | |
| SRP007169 | HPGD | 3248 | RNAseq | -5.8369 | 0.0000 | |
| SRP008496 | HPGD | 3248 | RNAseq | -4.5542 | 0.0000 | |
| SRP064894 | HPGD | 3248 | RNAseq | -3.1756 | 0.0000 | |
| SRP133303 | HPGD | 3248 | RNAseq | -2.7913 | 0.0000 | |
| SRP159526 | HPGD | 3248 | RNAseq | -3.6694 | 0.0000 | |
| SRP193095 | HPGD | 3248 | RNAseq | -3.8313 | 0.0000 | |
| SRP219564 | HPGD | 3248 | RNAseq | -3.2975 | 0.0018 | |
| TCGA | HPGD | 3248 | RNAseq | -1.4749 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 17.
Survival by HPGD expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of HPGD:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | HPGD | 3248 | 1 | 10 | 19 | |
| GSE20123 | HPGD | 3248 | 1 | 10 | 19 | |
| GSE43470 | HPGD | 3248 | 0 | 13 | 30 | |
| GSE46452 | HPGD | 3248 | 1 | 36 | 22 | |
| GSE47630 | HPGD | 3248 | 0 | 22 | 18 | |
| GSE54993 | HPGD | 3248 | 10 | 0 | 60 | |
| GSE54994 | HPGD | 3248 | 2 | 12 | 39 | |
| GSE60625 | HPGD | 3248 | 0 | 0 | 11 | |
| GSE74703 | HPGD | 3248 | 0 | 11 | 25 | |
| GSE74704 | HPGD | 3248 | 0 | 5 | 15 | |
| TCGA | HPGD | 3248 | 10 | 37 | 49 |
Total number of gains: 25; Total number of losses: 156; Total Number of normals: 307.
Somatic mutations of HPGD:
Generating mutation plots.
Highly correlated genes for HPGD:
Showing top 20/1880 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| HPGD | SASH1 | 0.874772 | 11 | 0 | 11 |
| HPGD | ETFDH | 0.866439 | 10 | 0 | 10 |
| HPGD | RMND5B | 0.86062 | 11 | 0 | 11 |
| HPGD | CGNL1 | 0.860441 | 7 | 0 | 7 |
| HPGD | C5orf66-AS1 | 0.86008 | 6 | 0 | 6 |
| HPGD | SNORA68 | 0.857641 | 4 | 0 | 4 |
| HPGD | CTTNBP2 | 0.857255 | 6 | 0 | 6 |
| HPGD | UBL3 | 0.855222 | 11 | 0 | 11 |
| HPGD | ACOX3 | 0.854391 | 10 | 0 | 10 |
| HPGD | CPEB3 | 0.8517 | 10 | 0 | 10 |
| HPGD | FAM214A | 0.851315 | 6 | 0 | 6 |
| HPGD | CA13 | 0.84791 | 3 | 0 | 3 |
| HPGD | ARHGEF10L | 0.843777 | 11 | 0 | 11 |
| HPGD | SIM2 | 0.838731 | 11 | 0 | 11 |
| HPGD | FCER1A | 0.836437 | 10 | 0 | 10 |
| HPGD | CCNG2 | 0.835194 | 11 | 0 | 11 |
| HPGD | SH3BGRL2 | 0.832505 | 8 | 0 | 7 |
| HPGD | MGLL | 0.831062 | 11 | 0 | 11 |
| HPGD | ALDH9A1 | 0.830199 | 11 | 0 | 11 |
| HPGD | GPD1L | 0.828928 | 12 | 0 | 11 |
For details and further investigation, click here
