| Full name: interferon lambda 1 | Alias Symbol: IL-29 | ||
| Type: protein-coding gene | Cytoband: 19q13.2 | ||
| Entrez ID: 282618 | HGNC ID: HGNC:18363 | Ensembl Gene: ENSG00000182393 | OMIM ID: 607403 |
| Drug and gene relationship at DGIdb | |||
IFNL1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04630 | Jak-STAT signaling pathway |
Expression of IFNL1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IFNL1 | 282618 | 1552917_at | -0.0463 | 0.9011 | |
| GSE26886 | IFNL1 | 282618 | 1552917_at | -0.0885 | 0.5128 | |
| GSE45670 | IFNL1 | 282618 | 1552917_at | 0.0695 | 0.5265 | |
| GSE53622 | IFNL1 | 282618 | 46014 | 0.2393 | 0.0109 | |
| GSE53624 | IFNL1 | 282618 | 46014 | 0.4016 | 0.0000 | |
| GSE63941 | IFNL1 | 282618 | 1552917_at | 0.0705 | 0.6763 | |
| GSE77861 | IFNL1 | 282618 | 1552917_at | -0.0940 | 0.3775 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IFNL1 expression:
 |  |
| GSE53622 | GSE53624 |
Note: Click image to view full size file.
Copy number change of IFNL1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IFNL1 | 282618 | 7 | 4 | 19 | |
| GSE20123 | IFNL1 | 282618 | 7 | 3 | 20 | |
| GSE43470 | IFNL1 | 282618 | 4 | 11 | 28 | |
| GSE46452 | IFNL1 | 282618 | 47 | 2 | 10 | |
| GSE47630 | IFNL1 | 282618 | 9 | 5 | 26 | |
| GSE54993 | IFNL1 | 282618 | 17 | 3 | 50 | |
| GSE54994 | IFNL1 | 282618 | 7 | 9 | 37 | |
| GSE60625 | IFNL1 | 282618 | 9 | 0 | 2 | |
| GSE74703 | IFNL1 | 282618 | 4 | 7 | 25 | |
| GSE74704 | IFNL1 | 282618 | 7 | 1 | 12 | |
| TCGA | IFNL1 | 282618 | 14 | 16 | 66 |
Total number of gains: 132; Total number of losses: 61; Total Number of normals: 295.
Somatic mutations of IFNL1:
Generating mutation plots.
Highly correlated genes for IFNL1:
Showing all 19 correlated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IFNL1 | ZNF582-AS1 | 0.622476 | 3 | 0 | 3 |
| IFNL1 | TMEM169 | 0.618027 | 3 | 0 | 3 |
| IFNL1 | F5 | 0.586628 | 3 | 0 | 3 |
| IFNL1 | RASGRF1 | 0.583554 | 3 | 0 | 3 |
| IFNL1 | ASB16 | 0.582107 | 4 | 0 | 4 |
| IFNL1 | IL2RG | 0.581978 | 3 | 0 | 3 |
| IFNL1 | TTLL7-IT1 | 0.581473 | 3 | 0 | 3 |
| IFNL1 | LMX1A | 0.564185 | 4 | 0 | 3 |
| IFNL1 | OR10H3 | 0.561233 | 3 | 0 | 3 |
| IFNL1 | LINC00557 | 0.558748 | 3 | 0 | 3 |
| IFNL1 | CD5 | 0.557582 | 4 | 0 | 3 |
| IFNL1 | PRPH2 | 0.550485 | 3 | 0 | 3 |
| IFNL1 | FOXN4 | 0.548442 | 4 | 0 | 3 |
| IFNL1 | WFDC9 | 0.548357 | 4 | 0 | 3 |
| IFNL1 | CCDC105 | 0.543819 | 4 | 0 | 3 |
| IFNL1 | CCDC54 | 0.521669 | 4 | 0 | 3 |
| IFNL1 | RNASE2 | 0.52008 | 4 | 0 | 3 |
| IFNL1 | RGSL1 | 0.517126 | 5 | 0 | 3 |
| IFNL1 | MX2 | 0.501108 | 4 | 0 | 3 |
For details and further investigation, click here
