| Full name: coagulation factor V | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 1q24.2 | ||
| Entrez ID: 2153 | HGNC ID: HGNC:3542 | Ensembl Gene: ENSG00000198734 | OMIM ID: 612309 |
| Drug and gene relationship at DGIdb | |||
F5 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04610 | Complement and coagulation cascades |
Expression of F5:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | F5 | 2153 | 204713_s_at | -0.2610 | 0.4496 | |
| GSE20347 | F5 | 2153 | 204713_s_at | -0.0054 | 0.9700 | |
| GSE23400 | F5 | 2153 | 204713_s_at | -0.1554 | 0.0003 | |
| GSE26886 | F5 | 2153 | 204713_s_at | -0.2308 | 0.0703 | |
| GSE29001 | F5 | 2153 | 204713_s_at | -0.0304 | 0.8580 | |
| GSE38129 | F5 | 2153 | 204713_s_at | -0.1530 | 0.1933 | |
| GSE45670 | F5 | 2153 | 204713_s_at | -0.1895 | 0.3608 | |
| GSE63941 | F5 | 2153 | 204713_s_at | 0.1824 | 0.3463 | |
| GSE77861 | F5 | 2153 | 204713_s_at | -0.1233 | 0.4129 | |
| SRP007169 | F5 | 2153 | RNAseq | 1.7979 | 0.0383 | |
| SRP064894 | F5 | 2153 | RNAseq | -0.6869 | 0.0925 | |
| SRP133303 | F5 | 2153 | RNAseq | -0.2291 | 0.4504 | |
| SRP159526 | F5 | 2153 | RNAseq | 1.5721 | 0.0162 | |
| SRP193095 | F5 | 2153 | RNAseq | -0.0033 | 0.9911 | |
| SRP219564 | F5 | 2153 | RNAseq | 0.5825 | 0.2203 | |
| TCGA | F5 | 2153 | RNAseq | -0.9145 | 0.0013 |
Upregulated datasets: 2; Downregulated datasets: 0.
Survival by F5 expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of F5:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | F5 | 2153 | 11 | 1 | 18 | |
| GSE20123 | F5 | 2153 | 11 | 1 | 18 | |
| GSE43470 | F5 | 2153 | 7 | 2 | 34 | |
| GSE46452 | F5 | 2153 | 3 | 1 | 55 | |
| GSE47630 | F5 | 2153 | 14 | 0 | 26 | |
| GSE54993 | F5 | 2153 | 0 | 6 | 64 | |
| GSE54994 | F5 | 2153 | 16 | 0 | 37 | |
| GSE60625 | F5 | 2153 | 0 | 0 | 11 | |
| GSE74703 | F5 | 2153 | 7 | 2 | 27 | |
| GSE74704 | F5 | 2153 | 5 | 0 | 15 | |
| TCGA | F5 | 2153 | 43 | 3 | 50 |
Total number of gains: 117; Total number of losses: 16; Total Number of normals: 355.
Somatic mutations of F5:
Generating mutation plots.
Highly correlated genes for F5:
Showing top 20/410 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| F5 | KRTAP5-8 | 0.674128 | 3 | 0 | 3 |
| F5 | CRHR2 | 0.671431 | 3 | 0 | 3 |
| F5 | GNRHR | 0.665869 | 3 | 0 | 3 |
| F5 | FMN1 | 0.66225 | 3 | 0 | 3 |
| F5 | TIAF1 | 0.656918 | 3 | 0 | 3 |
| F5 | SLC5A4 | 0.654169 | 3 | 0 | 3 |
| F5 | GDPD5 | 0.648385 | 3 | 0 | 3 |
| F5 | MUC5AC | 0.646868 | 4 | 0 | 4 |
| F5 | G6PC | 0.643427 | 4 | 0 | 4 |
| F5 | IFNA17 | 0.642432 | 3 | 0 | 3 |
| F5 | IL1RL1 | 0.641166 | 4 | 0 | 4 |
| F5 | ANO2 | 0.634546 | 3 | 0 | 3 |
| F5 | GCK | 0.634432 | 3 | 0 | 3 |
| F5 | GJB4 | 0.633729 | 3 | 0 | 3 |
| F5 | RS1 | 0.631668 | 3 | 0 | 3 |
| F5 | GRIP2 | 0.62712 | 4 | 0 | 3 |
| F5 | ZFHX2 | 0.626366 | 3 | 0 | 3 |
| F5 | RPS6KA6 | 0.625813 | 3 | 0 | 3 |
| F5 | UBE2D4 | 0.625106 | 4 | 0 | 4 |
| F5 | ARR3 | 0.621838 | 4 | 0 | 3 |
For details and further investigation, click here
