| Full name: Ras protein specific guanine nucleotide releasing factor 1 | Alias Symbol: CDC25L|CDC25|GRF55|H-GRF55|GNRP|PP13187 | ||
| Type: protein-coding gene | Cytoband: 15q25.1 | ||
| Entrez ID: 5923 | HGNC ID: HGNC:9875 | Ensembl Gene: ENSG00000058335 | OMIM ID: 606600 |
| Drug and gene relationship at DGIdb | |||
RASGRF1 involved pathways:
| KEGG pathway | Description | View |
|---|---|---|
| hsa04010 | MAPK signaling pathway | |
| hsa04014 | Ras signaling pathway | |
| hsa04510 | Focal adhesion |
Expression of RASGRF1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RASGRF1 | 5923 | 1554992_at | 0.0529 | 0.8955 | |
| GSE20347 | RASGRF1 | 5923 | 215688_at | -0.0047 | 0.9548 | |
| GSE23400 | RASGRF1 | 5923 | 215688_at | -0.0562 | 0.1268 | |
| GSE26886 | RASGRF1 | 5923 | 1554992_at | -0.1455 | 0.4602 | |
| GSE29001 | RASGRF1 | 5923 | 215688_at | -0.0306 | 0.9018 | |
| GSE38129 | RASGRF1 | 5923 | 215688_at | -0.1252 | 0.0897 | |
| GSE45670 | RASGRF1 | 5923 | 215688_at | 0.0184 | 0.8620 | |
| GSE53622 | RASGRF1 | 5923 | 52199 | 0.3011 | 0.1453 | |
| GSE53624 | RASGRF1 | 5923 | 52199 | 0.4632 | 0.0088 | |
| GSE63941 | RASGRF1 | 5923 | 215688_at | 0.2251 | 0.2973 | |
| GSE77861 | RASGRF1 | 5923 | 1554992_at | -0.1321 | 0.3637 | |
| GSE97050 | RASGRF1 | 5923 | A_23_P3379 | 0.4172 | 0.3565 | |
| SRP133303 | RASGRF1 | 5923 | RNAseq | 0.5597 | 0.0706 | |
| TCGA | RASGRF1 | 5923 | RNAseq | 1.0864 | 0.0117 |
Upregulated datasets: 1; Downregulated datasets: 0.
Survival by RASGRF1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RASGRF1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RASGRF1 | 5923 | 7 | 1 | 22 | |
| GSE20123 | RASGRF1 | 5923 | 7 | 1 | 22 | |
| GSE43470 | RASGRF1 | 5923 | 4 | 5 | 34 | |
| GSE46452 | RASGRF1 | 5923 | 3 | 7 | 49 | |
| GSE47630 | RASGRF1 | 5923 | 8 | 10 | 22 | |
| GSE54993 | RASGRF1 | 5923 | 5 | 6 | 59 | |
| GSE54994 | RASGRF1 | 5923 | 5 | 6 | 42 | |
| GSE60625 | RASGRF1 | 5923 | 4 | 0 | 7 | |
| GSE74703 | RASGRF1 | 5923 | 4 | 3 | 29 | |
| GSE74704 | RASGRF1 | 5923 | 3 | 1 | 16 | |
| TCGA | RASGRF1 | 5923 | 13 | 16 | 67 |
Total number of gains: 63; Total number of losses: 56; Total Number of normals: 369.
Somatic mutations of RASGRF1:
Generating mutation plots.
Highly correlated genes for RASGRF1:
Showing top 20/576 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RASGRF1 | CRISP1 | 0.689935 | 6 | 0 | 6 |
| RASGRF1 | LINC00652 | 0.679824 | 3 | 0 | 3 |
| RASGRF1 | CGA | 0.677378 | 7 | 0 | 7 |
| RASGRF1 | ECE2 | 0.676671 | 5 | 0 | 4 |
| RASGRF1 | AFF2 | 0.666737 | 3 | 0 | 3 |
| RASGRF1 | CETN1 | 0.665337 | 5 | 0 | 5 |
| RASGRF1 | KLK2 | 0.660518 | 6 | 0 | 4 |
| RASGRF1 | G6PC2 | 0.657929 | 6 | 0 | 5 |
| RASGRF1 | TNFRSF13B | 0.657483 | 3 | 0 | 3 |
| RASGRF1 | NEURL1 | 0.654608 | 4 | 0 | 4 |
| RASGRF1 | CHRNB2 | 0.652154 | 4 | 0 | 4 |
| RASGRF1 | OR3A2 | 0.647287 | 3 | 0 | 3 |
| RASGRF1 | MRO | 0.647138 | 3 | 0 | 3 |
| RASGRF1 | IFNA4 | 0.643824 | 4 | 0 | 4 |
| RASGRF1 | NTNG1 | 0.643594 | 4 | 0 | 4 |
| RASGRF1 | CDKL5 | 0.642855 | 4 | 0 | 3 |
| RASGRF1 | ART1 | 0.638714 | 5 | 0 | 5 |
| RASGRF1 | KCNJ3 | 0.635359 | 6 | 0 | 5 |
| RASGRF1 | FAM163A | 0.635108 | 3 | 0 | 3 |
| RASGRF1 | KIAA1614 | 0.634304 | 5 | 0 | 4 |
For details and further investigation, click here
