| Full name: ribonuclease A family member 2 | Alias Symbol: EDN|RAF3 | ||
| Type: protein-coding gene | Cytoband: 14q11.2 | ||
| Entrez ID: 6036 | HGNC ID: HGNC:10045 | Ensembl Gene: ENSG00000169385 | OMIM ID: 131410 |
| Drug and gene relationship at DGIdb | |||
Expression of RNASE2:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | RNASE2 | 6036 | 206111_at | -0.0283 | 0.9518 | |
| GSE20347 | RNASE2 | 6036 | 206111_at | 0.0543 | 0.3571 | |
| GSE23400 | RNASE2 | 6036 | 206111_at | -0.0659 | 0.0828 | |
| GSE26886 | RNASE2 | 6036 | 206111_at | 0.0706 | 0.6898 | |
| GSE29001 | RNASE2 | 6036 | 206111_at | 0.0971 | 0.4811 | |
| GSE38129 | RNASE2 | 6036 | 206111_at | 0.0758 | 0.3476 | |
| GSE45670 | RNASE2 | 6036 | 206111_at | 0.1444 | 0.1561 | |
| GSE53622 | RNASE2 | 6036 | 37122 | 1.2207 | 0.0000 | |
| GSE53624 | RNASE2 | 6036 | 37122 | 1.6862 | 0.0000 | |
| GSE63941 | RNASE2 | 6036 | 206111_at | 0.1446 | 0.2483 | |
| GSE77861 | RNASE2 | 6036 | 206111_at | -0.2284 | 0.1404 | |
| GSE97050 | RNASE2 | 6036 | A_32_P1712 | 0.7570 | 0.2206 | |
| TCGA | RNASE2 | 6036 | RNAseq | 1.7150 | 0.0000 |
Upregulated datasets: 3; Downregulated datasets: 0.
Survival by RNASE2 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of RNASE2:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | RNASE2 | 6036 | 9 | 3 | 18 | |
| GSE20123 | RNASE2 | 6036 | 8 | 3 | 19 | |
| GSE43470 | RNASE2 | 6036 | 7 | 1 | 35 | |
| GSE46452 | RNASE2 | 6036 | 19 | 2 | 38 | |
| GSE47630 | RNASE2 | 6036 | 10 | 10 | 20 | |
| GSE54993 | RNASE2 | 6036 | 3 | 11 | 56 | |
| GSE54994 | RNASE2 | 6036 | 18 | 5 | 30 | |
| GSE60625 | RNASE2 | 6036 | 0 | 2 | 9 | |
| GSE74703 | RNASE2 | 6036 | 6 | 1 | 29 | |
| GSE74704 | RNASE2 | 6036 | 4 | 2 | 14 | |
| TCGA | RNASE2 | 6036 | 27 | 16 | 53 |
Total number of gains: 111; Total number of losses: 56; Total Number of normals: 321.
Somatic mutations of RNASE2:
Generating mutation plots.
Highly correlated genes for RNASE2:
Showing top 20/265 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| RNASE2 | TYROBP | 0.755146 | 4 | 0 | 4 |
| RNASE2 | LRRC10B | 0.747442 | 3 | 0 | 3 |
| RNASE2 | C1QB | 0.708113 | 4 | 0 | 4 |
| RNASE2 | SIGLEC12 | 0.699773 | 3 | 0 | 3 |
| RNASE2 | FCGR2B | 0.697582 | 3 | 0 | 3 |
| RNASE2 | FCER1G | 0.690265 | 4 | 0 | 3 |
| RNASE2 | LRRC25 | 0.688629 | 6 | 0 | 5 |
| RNASE2 | GPR84 | 0.68083 | 4 | 0 | 3 |
| RNASE2 | CLEC12A | 0.669751 | 3 | 0 | 3 |
| RNASE2 | PLXNC1 | 0.669012 | 4 | 0 | 3 |
| RNASE2 | TFEC | 0.665077 | 5 | 0 | 4 |
| RNASE2 | CCRL2 | 0.661542 | 6 | 0 | 4 |
| RNASE2 | PDIA5 | 0.655717 | 3 | 0 | 3 |
| RNASE2 | TDO2 | 0.655685 | 4 | 0 | 3 |
| RNASE2 | PIK3AP1 | 0.653737 | 4 | 0 | 3 |
| RNASE2 | IFIT3 | 0.652155 | 4 | 0 | 4 |
| RNASE2 | CCL18 | 0.651862 | 5 | 0 | 4 |
| RNASE2 | LRRC8C | 0.65105 | 3 | 0 | 3 |
| RNASE2 | PDE6B | 0.646252 | 3 | 0 | 3 |
| RNASE2 | FCGR3A | 0.646161 | 4 | 0 | 3 |
For details and further investigation, click here
