| Full name: spectrin beta, non-erythrocytic 4 | Alias Symbol: SPTBN3|KIAA1642 | ||
| Type: protein-coding gene | Cytoband: 19q13.13 | ||
| Entrez ID: 57731 | HGNC ID: HGNC:14896 | Ensembl Gene: ENSG00000160460 | OMIM ID: 606214 |
| Drug and gene relationship at DGIdb | |||
Expression of SPTBN4:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | SPTBN4 | 57731 | 220185_at | -0.1958 | 0.4781 | |
| GSE20347 | SPTBN4 | 57731 | 220185_at | -0.0738 | 0.3229 | |
| GSE23400 | SPTBN4 | 57731 | 220185_at | -0.1264 | 0.0001 | |
| GSE26886 | SPTBN4 | 57731 | 220185_at | 0.0060 | 0.9633 | |
| GSE29001 | SPTBN4 | 57731 | 220185_at | -0.3805 | 0.0107 | |
| GSE38129 | SPTBN4 | 57731 | 220185_at | -0.1640 | 0.0268 | |
| GSE45670 | SPTBN4 | 57731 | 224145_s_at | -0.2035 | 0.0870 | |
| GSE53622 | SPTBN4 | 57731 | 94017 | 0.1466 | 0.0855 | |
| GSE53624 | SPTBN4 | 57731 | 94017 | 0.3238 | 0.0030 | |
| GSE63941 | SPTBN4 | 57731 | 224297_s_at | 0.0445 | 0.7847 | |
| GSE77861 | SPTBN4 | 57731 | 220185_at | -0.1277 | 0.3866 | |
| GSE97050 | SPTBN4 | 57731 | A_33_P3401459 | 0.0553 | 0.8536 | |
| SRP064894 | SPTBN4 | 57731 | RNAseq | -0.4606 | 0.3398 | |
| SRP133303 | SPTBN4 | 57731 | RNAseq | -0.5856 | 0.3010 | |
| SRP159526 | SPTBN4 | 57731 | RNAseq | 0.1015 | 0.8037 | |
| SRP219564 | SPTBN4 | 57731 | RNAseq | -0.6166 | 0.4757 | |
| TCGA | SPTBN4 | 57731 | RNAseq | -1.4666 | 0.0000 |
Upregulated datasets: 0; Downregulated datasets: 1.
Survival by SPTBN4 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of SPTBN4:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | SPTBN4 | 57731 | 6 | 5 | 19 | |
| GSE20123 | SPTBN4 | 57731 | 6 | 4 | 20 | |
| GSE43470 | SPTBN4 | 57731 | 3 | 9 | 31 | |
| GSE46452 | SPTBN4 | 57731 | 48 | 1 | 10 | |
| GSE47630 | SPTBN4 | 57731 | 9 | 5 | 26 | |
| GSE54993 | SPTBN4 | 57731 | 17 | 4 | 49 | |
| GSE54994 | SPTBN4 | 57731 | 8 | 9 | 36 | |
| GSE60625 | SPTBN4 | 57731 | 9 | 0 | 2 | |
| GSE74703 | SPTBN4 | 57731 | 3 | 6 | 27 | |
| GSE74704 | SPTBN4 | 57731 | 6 | 2 | 12 | |
| TCGA | SPTBN4 | 57731 | 14 | 16 | 66 |
Total number of gains: 129; Total number of losses: 61; Total Number of normals: 298.
Somatic mutations of SPTBN4:
Generating mutation plots.
Highly correlated genes for SPTBN4:
Showing top 20/1007 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| SPTBN4 | SPRY3 | 0.835884 | 3 | 0 | 3 |
| SPTBN4 | NKX6-3 | 0.822598 | 3 | 0 | 3 |
| SPTBN4 | C9orf153 | 0.791252 | 3 | 0 | 3 |
| SPTBN4 | NPR2 | 0.788753 | 3 | 0 | 3 |
| SPTBN4 | C1QL2 | 0.780812 | 3 | 0 | 3 |
| SPTBN4 | DCDC1 | 0.780077 | 3 | 0 | 3 |
| SPTBN4 | DEFB121 | 0.774154 | 3 | 0 | 3 |
| SPTBN4 | YY2 | 0.768464 | 3 | 0 | 3 |
| SPTBN4 | C2CD4D | 0.762186 | 3 | 0 | 3 |
| SPTBN4 | FAM131A | 0.754921 | 3 | 0 | 3 |
| SPTBN4 | PLA2G2C | 0.754419 | 3 | 0 | 3 |
| SPTBN4 | NTNG2 | 0.753542 | 4 | 0 | 4 |
| SPTBN4 | MRGPRG | 0.75298 | 3 | 0 | 3 |
| SPTBN4 | SLC39A5 | 0.751604 | 3 | 0 | 3 |
| SPTBN4 | SYPL2 | 0.748607 | 3 | 0 | 3 |
| SPTBN4 | BSX | 0.747437 | 3 | 0 | 3 |
| SPTBN4 | CHST10 | 0.747358 | 4 | 0 | 4 |
| SPTBN4 | ANKRD33B | 0.746259 | 4 | 0 | 4 |
| SPTBN4 | RBM43 | 0.742368 | 3 | 0 | 3 |
| SPTBN4 | TXNDC2 | 0.741803 | 4 | 0 | 4 |
For details and further investigation, click here
