| Full name: alanine--glyoxylate and serine--pyruvate aminotransferase | Alias Symbol: AGXT1|PH1|AGT|SPT|AGT1 | ||
| Type: protein-coding gene | Cytoband: 2q37.3 | ||
| Entrez ID: 189 | HGNC ID: HGNC:341 | Ensembl Gene: ENSG00000172482 | OMIM ID: 604285 |
| Drug and gene relationship at DGIdb | |||
Expression of AGXT:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AGXT | 189 | 210326_at | -0.1476 | 0.6005 | |
| GSE20347 | AGXT | 189 | 210326_at | 0.0482 | 0.6152 | |
| GSE23400 | AGXT | 189 | 210326_at | -0.1656 | 0.0001 | |
| GSE26886 | AGXT | 189 | 210326_at | 0.0681 | 0.6143 | |
| GSE29001 | AGXT | 189 | 210326_at | -0.1575 | 0.1472 | |
| GSE38129 | AGXT | 189 | 210326_at | -0.1024 | 0.2224 | |
| GSE45670 | AGXT | 189 | 210326_at | -0.0799 | 0.2998 | |
| GSE53622 | AGXT | 189 | 84271 | -0.0309 | 0.6960 | |
| GSE53624 | AGXT | 189 | 84271 | 0.1360 | 0.1556 | |
| GSE63941 | AGXT | 189 | 210326_at | 0.1314 | 0.4564 | |
| GSE77861 | AGXT | 189 | 210326_at | 0.0067 | 0.9697 | |
| GSE97050 | AGXT | 189 | A_33_P3250278 | -0.1219 | 0.6268 | |
| SRP133303 | AGXT | 189 | RNAseq | -0.8867 | 0.0037 | |
| TCGA | AGXT | 189 | RNAseq | 1.7843 | 0.2380 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by AGXT expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AGXT:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AGXT | 189 | 1 | 12 | 17 | |
| GSE20123 | AGXT | 189 | 1 | 12 | 17 | |
| GSE43470 | AGXT | 189 | 1 | 9 | 33 | |
| GSE46452 | AGXT | 189 | 0 | 5 | 54 | |
| GSE47630 | AGXT | 189 | 4 | 5 | 31 | |
| GSE54993 | AGXT | 189 | 4 | 3 | 63 | |
| GSE54994 | AGXT | 189 | 8 | 9 | 36 | |
| GSE60625 | AGXT | 189 | 0 | 3 | 8 | |
| GSE74703 | AGXT | 189 | 1 | 7 | 28 | |
| GSE74704 | AGXT | 189 | 1 | 5 | 14 | |
| TCGA | AGXT | 189 | 11 | 29 | 56 |
Total number of gains: 32; Total number of losses: 99; Total Number of normals: 357.
Somatic mutations of AGXT:
Generating mutation plots.
Highly correlated genes for AGXT:
Showing top 20/920 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AGXT | ACRBP | 0.784862 | 3 | 0 | 3 |
| AGXT | CLDN19 | 0.747242 | 3 | 0 | 3 |
| AGXT | EFCAB5 | 0.721222 | 3 | 0 | 3 |
| AGXT | LINC00163 | 0.710163 | 3 | 0 | 3 |
| AGXT | IFNL2 | 0.703912 | 3 | 0 | 3 |
| AGXT | SHANK2-AS3 | 0.699333 | 3 | 0 | 3 |
| AGXT | TCTE1 | 0.698768 | 3 | 0 | 3 |
| AGXT | PLK5 | 0.696102 | 3 | 0 | 3 |
| AGXT | ASCL5 | 0.690666 | 3 | 0 | 3 |
| AGXT | STX1B | 0.688413 | 3 | 0 | 3 |
| AGXT | RIT2 | 0.685634 | 5 | 0 | 5 |
| AGXT | FZD9 | 0.684693 | 5 | 0 | 5 |
| AGXT | KCNH3 | 0.67589 | 5 | 0 | 5 |
| AGXT | TTTY11 | 0.673374 | 3 | 0 | 3 |
| AGXT | ZNF169 | 0.658052 | 5 | 0 | 5 |
| AGXT | IL1RAPL2 | 0.656516 | 4 | 0 | 4 |
| AGXT | GH1 | 0.656009 | 6 | 0 | 5 |
| AGXT | SLC32A1 | 0.65274 | 3 | 0 | 3 |
| AGXT | CD33 | 0.651756 | 4 | 0 | 4 |
| AGXT | C1orf105 | 0.650451 | 5 | 0 | 4 |
For details and further investigation, click here
