| Full name: adenylate kinase 1 | Alias Symbol: | ||
| Type: protein-coding gene | Cytoband: 9q34.11 | ||
| Entrez ID: 203 | HGNC ID: HGNC:361 | Ensembl Gene: ENSG00000106992 | OMIM ID: 103000 |
| Drug and gene relationship at DGIdb | |||
Expression of AK1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | AK1 | 203 | 202587_s_at | -0.1706 | 0.7644 | |
| GSE20347 | AK1 | 203 | 202587_s_at | -0.4928 | 0.0220 | |
| GSE23400 | AK1 | 203 | 202587_s_at | -0.3225 | 0.0023 | |
| GSE26886 | AK1 | 203 | 202587_s_at | 0.0861 | 0.8039 | |
| GSE29001 | AK1 | 203 | 202588_at | -0.2390 | 0.1846 | |
| GSE38129 | AK1 | 203 | 202587_s_at | -0.5579 | 0.0065 | |
| GSE45670 | AK1 | 203 | 202587_s_at | -0.2827 | 0.1149 | |
| GSE53622 | AK1 | 203 | 38414 | 0.4321 | 0.0001 | |
| GSE53624 | AK1 | 203 | 38414 | 0.2110 | 0.0091 | |
| GSE63941 | AK1 | 203 | 202587_s_at | 0.4920 | 0.3983 | |
| GSE77861 | AK1 | 203 | 202587_s_at | -0.1330 | 0.6584 | |
| GSE97050 | AK1 | 203 | A_24_P278192 | 0.0274 | 0.9076 | |
| SRP007169 | AK1 | 203 | RNAseq | -0.9152 | 0.1656 | |
| SRP008496 | AK1 | 203 | RNAseq | -0.5763 | 0.1134 | |
| SRP064894 | AK1 | 203 | RNAseq | 0.6330 | 0.1345 | |
| SRP133303 | AK1 | 203 | RNAseq | -0.0355 | 0.8751 | |
| SRP159526 | AK1 | 203 | RNAseq | -0.3277 | 0.1465 | |
| SRP193095 | AK1 | 203 | RNAseq | -0.0502 | 0.7246 | |
| SRP219564 | AK1 | 203 | RNAseq | -0.2104 | 0.6742 | |
| TCGA | AK1 | 203 | RNAseq | -0.1422 | 0.0792 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by AK1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of AK1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | AK1 | 203 | 6 | 9 | 15 | |
| GSE20123 | AK1 | 203 | 6 | 9 | 15 | |
| GSE43470 | AK1 | 203 | 5 | 7 | 31 | |
| GSE46452 | AK1 | 203 | 6 | 13 | 40 | |
| GSE47630 | AK1 | 203 | 3 | 16 | 21 | |
| GSE54993 | AK1 | 203 | 3 | 3 | 64 | |
| GSE54994 | AK1 | 203 | 11 | 8 | 34 | |
| GSE60625 | AK1 | 203 | 0 | 0 | 11 | |
| GSE74703 | AK1 | 203 | 5 | 5 | 26 | |
| GSE74704 | AK1 | 203 | 3 | 7 | 10 | |
| TCGA | AK1 | 203 | 27 | 25 | 44 |
Total number of gains: 75; Total number of losses: 102; Total Number of normals: 311.
Somatic mutations of AK1:
Generating mutation plots.
Highly correlated genes for AK1:
Showing top 20/194 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| AK1 | KRTAP10-3 | 0.795045 | 3 | 0 | 3 |
| AK1 | VWA5B1 | 0.760193 | 3 | 0 | 3 |
| AK1 | IFNL2 | 0.724314 | 3 | 0 | 3 |
| AK1 | SLC6A3 | 0.713796 | 3 | 0 | 3 |
| AK1 | FAM131A | 0.700595 | 3 | 0 | 3 |
| AK1 | LRRC71 | 0.695928 | 3 | 0 | 3 |
| AK1 | LINC00454 | 0.685883 | 3 | 0 | 3 |
| AK1 | FAM193B | 0.684027 | 3 | 0 | 3 |
| AK1 | RPRML | 0.681363 | 3 | 0 | 3 |
| AK1 | LCNL1 | 0.680588 | 4 | 0 | 4 |
| AK1 | SEZ6 | 0.671707 | 5 | 0 | 4 |
| AK1 | ZSCAN30 | 0.671191 | 3 | 0 | 3 |
| AK1 | ZSCAN16-AS1 | 0.670795 | 3 | 0 | 3 |
| AK1 | TCF23 | 0.670606 | 3 | 0 | 3 |
| AK1 | CPLX2 | 0.670277 | 5 | 0 | 4 |
| AK1 | STARD7-AS1 | 0.666693 | 3 | 0 | 3 |
| AK1 | GRIP2 | 0.660834 | 4 | 0 | 4 |
| AK1 | GCM2 | 0.659711 | 4 | 0 | 4 |
| AK1 | PDE5A | 0.656461 | 3 | 0 | 3 |
| AK1 | LINC01136 | 0.656073 | 4 | 0 | 3 |
For details and further investigation, click here
