PDGFB

 

Full name: platelet derived growth factor subunit B Alias Symbol: SSV
Type: protein-coding gene Cytoband: 22q13.1
Entrez ID: 5155 HGNC ID: HGNC:8800 Ensembl Gene: ENSG00000100311 OMIM ID: 190040
Drug and gene relationship at DGIdb

 

PDGFB involved pathways:

KEGG pathway Description View
hsa04010MAPK signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04072Phospholipase D signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04510Focal adhesion
hsa04540Gap junction
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
hsa05231Choline metabolism in cancer

 

Expression of PDGFB:

 

Dataset Gene EntrezID Probe Log2FC Adj.pValue Expression
GSE17351 PDGFB 5155 216061_x_at -0.0166 0.9746
GSE20347 PDGFB 5155 216061_x_at 0.3008 0.0067
GSE23400 PDGFB 5155 216061_x_at 0.0351 0.2875
GSE26886 PDGFB 5155 216061_x_at 0.5762 0.0011
GSE29001 PDGFB 5155 216061_x_at 0.1167 0.6287
GSE38129 PDGFB 5155 216061_x_at 0.1766 0.0620
GSE45670 PDGFB 5155 216061_x_at 0.1254 0.4109
GSE53622 PDGFB 5155 101934 0.4922 0.0000
GSE53624 PDGFB 5155 101934 0.5056 0.0000
GSE63941 PDGFB 5155 216061_x_at 0.5790 0.0667
GSE77861 PDGFB 5155 216061_x_at 0.2451 0.2701
GSE97050 PDGFB 5155 A_24_P339944 0.0606 0.8040
SRP007169 PDGFB 5155 RNAseq 1.6302 0.0012
SRP008496 PDGFB 5155 RNAseq 1.5350 0.0010
SRP064894 PDGFB 5155 RNAseq 1.4255 0.0000
SRP133303 PDGFB 5155 RNAseq 0.5381 0.1242
SRP159526 PDGFB 5155 RNAseq 1.3105 0.0000
SRP193095 PDGFB 5155 RNAseq 2.2121 0.0000
SRP219564 PDGFB 5155 RNAseq 0.6777 0.2182
TCGA PDGFB 5155 RNAseq 0.0605 0.5506

Upregulated datasets: 5; Downregulated datasets: 0.  

 

Survival by PDGFB expression:

 

GSE53622GSE53624TCGA

 

Note: Click image to view full size file.  

Copy number change of PDGFB:

 

Dataset Gene EntrezID Gain Loss Normal Detail
GSE15526 PDGFB 5155 6 5 19
GSE20123 PDGFB 5155 6 4 20
GSE43470 PDGFB 5155 5 5 33
GSE46452 PDGFB 5155 32 2 25
GSE47630 PDGFB 5155 9 4 27
GSE54993 PDGFB 5155 3 6 61
GSE54994 PDGFB 5155 10 7 36
GSE60625 PDGFB 5155 5 0 6
GSE74703 PDGFB 5155 5 4 27
GSE74704 PDGFB 5155 3 2 15
TCGA PDGFB 5155 26 16 54

Total number of gains: 110; Total number of losses: 55; Total Number of normals: 323.  

 

Somatic mutations of PDGFB:

 

Generating mutation plots.

 

Highly correlated genes for PDGFB:

 

Showing top 20/649 corelated genes with mean PCC>0.5.
Gene1 Gene2 Mean PCC Num. Datasets Num. PCC<0 Num. PCC>0.5
PDGFBLINGO10.751978303
PDGFBIFNL20.731203303
PDGFBEVL0.729013303
PDGFBSLC26A50.727521303
PDGFBALG110.722222303
PDGFBKRTAP12-20.717779303
PDGFBPCBP30.712716404
PDGFBID30.700717404
PDGFBMOB3A0.699329404
PDGFBFIBCD10.695238605
PDGFBABHD10.694064404
PDGFBMATN40.69136404
PDGFBOR2T120.688886303
PDGFBFCGRT0.687667303
PDGFBCHGA0.687276303
PDGFBMAN1B10.687063303
PDGFBOR2T330.684437303
PDGFBINTS10.681092303
PDGFBNT5M0.67668303
PDGFBOR1L60.675591303

For details and further investigation, click here