| Full name: insulin like growth factor binding protein 1 | Alias Symbol: IGF-BP25|AFBP|hIGFBP-1|PP12 | ||
| Type: protein-coding gene | Cytoband: 7p12.3 | ||
| Entrez ID: 3484 | HGNC ID: HGNC:5469 | Ensembl Gene: ENSG00000146678 | OMIM ID: 146730 |
| Drug and gene relationship at DGIdb | |||
Expression of IGFBP1:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | IGFBP1 | 3484 | 205302_at | 0.1871 | 0.4558 | |
| GSE20347 | IGFBP1 | 3484 | 205302_at | 0.0180 | 0.7350 | |
| GSE23400 | IGFBP1 | 3484 | 205302_at | -0.0356 | 0.0341 | |
| GSE26886 | IGFBP1 | 3484 | 237989_at | 0.1639 | 0.1142 | |
| GSE29001 | IGFBP1 | 3484 | 205302_at | 0.0113 | 0.9497 | |
| GSE38129 | IGFBP1 | 3484 | 205302_at | 0.0122 | 0.8017 | |
| GSE45670 | IGFBP1 | 3484 | 237989_at | -0.0204 | 0.8041 | |
| GSE53622 | IGFBP1 | 3484 | 23164 | 0.7945 | 0.0000 | |
| GSE53624 | IGFBP1 | 3484 | 23164 | 0.6444 | 0.0000 | |
| GSE63941 | IGFBP1 | 3484 | 237989_at | -0.0123 | 0.9246 | |
| GSE77861 | IGFBP1 | 3484 | 237989_at | -0.1007 | 0.2219 | |
| TCGA | IGFBP1 | 3484 | RNAseq | 0.0826 | 0.9252 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by IGFBP1 expression:
 |  |  |
| GSE53622 | GSE53624 | TCGA |
Note: Click image to view full size file.
Copy number change of IGFBP1:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | IGFBP1 | 3484 | 15 | 0 | 15 | |
| GSE20123 | IGFBP1 | 3484 | 13 | 0 | 17 | |
| GSE43470 | IGFBP1 | 3484 | 4 | 0 | 39 | |
| GSE46452 | IGFBP1 | 3484 | 11 | 1 | 47 | |
| GSE47630 | IGFBP1 | 3484 | 8 | 1 | 31 | |
| GSE54993 | IGFBP1 | 3484 | 0 | 8 | 62 | |
| GSE54994 | IGFBP1 | 3484 | 16 | 3 | 34 | |
| GSE60625 | IGFBP1 | 3484 | 0 | 0 | 11 | |
| GSE74703 | IGFBP1 | 3484 | 4 | 0 | 32 | |
| GSE74704 | IGFBP1 | 3484 | 7 | 0 | 13 | |
| TCGA | IGFBP1 | 3484 | 50 | 7 | 39 |
Total number of gains: 128; Total number of losses: 20; Total Number of normals: 340.
Somatic mutations of IGFBP1:
Generating mutation plots.
Highly correlated genes for IGFBP1:
Showing top 20/126 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| IGFBP1 | SLC17A3 | 0.721798 | 3 | 0 | 3 |
| IGFBP1 | RIT2 | 0.632073 | 3 | 0 | 3 |
| IGFBP1 | MYH8 | 0.631886 | 3 | 0 | 3 |
| IGFBP1 | SSTR4 | 0.631464 | 3 | 0 | 3 |
| IGFBP1 | FAM163A | 0.629476 | 3 | 0 | 3 |
| IGFBP1 | PSG7 | 0.62605 | 3 | 0 | 3 |
| IGFBP1 | PPM1E | 0.62242 | 3 | 0 | 3 |
| IGFBP1 | DNAAF1 | 0.620242 | 4 | 0 | 3 |
| IGFBP1 | HRG | 0.618481 | 3 | 0 | 3 |
| IGFBP1 | NEUROD2 | 0.616649 | 3 | 0 | 3 |
| IGFBP1 | IL9 | 0.615881 | 3 | 0 | 3 |
| IGFBP1 | DNMT3L | 0.61195 | 4 | 0 | 3 |
| IGFBP1 | ADRA1D | 0.611646 | 3 | 0 | 3 |
| IGFBP1 | CD5L | 0.609774 | 4 | 0 | 3 |
| IGFBP1 | MIOX | 0.609353 | 3 | 0 | 3 |
| IGFBP1 | WNT16 | 0.609021 | 4 | 0 | 3 |
| IGFBP1 | TAS2R3 | 0.608648 | 3 | 0 | 3 |
| IGFBP1 | MPO | 0.608115 | 4 | 0 | 3 |
| IGFBP1 | GRK6 | 0.606429 | 3 | 0 | 3 |
| IGFBP1 | MGRN1 | 0.605802 | 3 | 0 | 3 |
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