| Full name: DNA methyltransferase 3 like | Alias Symbol: MGC1090 | ||
| Type: protein-coding gene | Cytoband: 21q22.3 | ||
| Entrez ID: 29947 | HGNC ID: HGNC:2980 | Ensembl Gene: ENSG00000142182 | OMIM ID: 606588 |
| Drug and gene relationship at DGIdb | |||
Expression of DNMT3L:
| Dataset | Gene | EntrezID | Probe | Log2FC | Adj.pValue | Expression |
|---|---|---|---|---|---|---|
| GSE17351 | DNMT3L | 29947 | 220139_at | 0.0657 | 0.8592 | |
| GSE20347 | DNMT3L | 29947 | 220139_at | 0.0366 | 0.5960 | |
| GSE23400 | DNMT3L | 29947 | 220139_at | -0.0756 | 0.0193 | |
| GSE26886 | DNMT3L | 29947 | 220139_at | 0.1215 | 0.3095 | |
| GSE29001 | DNMT3L | 29947 | 220139_at | 0.0260 | 0.9119 | |
| GSE38129 | DNMT3L | 29947 | 220139_at | -0.0242 | 0.6829 | |
| GSE45670 | DNMT3L | 29947 | 220139_at | 0.0926 | 0.2036 | |
| GSE63941 | DNMT3L | 29947 | 220139_at | 0.0589 | 0.7727 | |
| GSE77861 | DNMT3L | 29947 | 220139_at | -0.1020 | 0.2965 |
Upregulated datasets: 0; Downregulated datasets: 0.
Survival by DNMT3L expression:
 |
| TCGA |
Note: Click image to view full size file.
Copy number change of DNMT3L:
| Dataset | Gene | EntrezID | Gain | Loss | Normal | Detail |
|---|---|---|---|---|---|---|
| GSE15526 | DNMT3L | 29947 | 2 | 8 | 20 | |
| GSE20123 | DNMT3L | 29947 | 2 | 8 | 20 | |
| GSE43470 | DNMT3L | 29947 | 0 | 13 | 30 | |
| GSE46452 | DNMT3L | 29947 | 1 | 21 | 37 | |
| GSE47630 | DNMT3L | 29947 | 6 | 17 | 17 | |
| GSE54993 | DNMT3L | 29947 | 8 | 1 | 61 | |
| GSE54994 | DNMT3L | 29947 | 4 | 8 | 41 | |
| GSE60625 | DNMT3L | 29947 | 0 | 0 | 11 | |
| GSE74703 | DNMT3L | 29947 | 0 | 10 | 26 | |
| GSE74704 | DNMT3L | 29947 | 1 | 4 | 15 | |
| TCGA | DNMT3L | 29947 | 8 | 39 | 49 |
Total number of gains: 32; Total number of losses: 129; Total Number of normals: 327.
Somatic mutations of DNMT3L:
Generating mutation plots.
Highly correlated genes for DNMT3L:
Showing top 20/589 corelated genes with mean PCC>0.5.
| Gene1 | Gene2 | Mean PCC | Num. Datasets | Num. PCC<0 | Num. PCC>0.5 |
|---|---|---|---|---|---|
| DNMT3L | MEFV | 0.729962 | 3 | 0 | 3 |
| DNMT3L | ADCYAP1 | 0.71909 | 3 | 0 | 3 |
| DNMT3L | LCT | 0.714366 | 3 | 0 | 3 |
| DNMT3L | HUNK | 0.711237 | 4 | 0 | 4 |
| DNMT3L | INHA | 0.70852 | 3 | 0 | 3 |
| DNMT3L | P2RY4 | 0.702112 | 3 | 0 | 3 |
| DNMT3L | ADH6 | 0.701756 | 3 | 0 | 3 |
| DNMT3L | MTAP | 0.699497 | 3 | 0 | 3 |
| DNMT3L | KCNA1 | 0.699465 | 4 | 0 | 4 |
| DNMT3L | RPGRIP1 | 0.698156 | 3 | 0 | 3 |
| DNMT3L | TBXA2R | 0.697897 | 4 | 0 | 4 |
| DNMT3L | KCNC4 | 0.695828 | 4 | 0 | 4 |
| DNMT3L | NTNG1 | 0.695051 | 3 | 0 | 3 |
| DNMT3L | ACTL7B | 0.694579 | 3 | 0 | 3 |
| DNMT3L | AVPR1A | 0.692143 | 4 | 0 | 4 |
| DNMT3L | PNMT | 0.691365 | 5 | 0 | 5 |
| DNMT3L | BLK | 0.688198 | 3 | 0 | 3 |
| DNMT3L | SLC6A5 | 0.685621 | 3 | 0 | 3 |
| DNMT3L | NTRK3 | 0.684503 | 3 | 0 | 3 |
| DNMT3L | CALCB | 0.681112 | 3 | 0 | 3 |
For details and further investigation, click here
